Navigation Links
Targeted antibacterial proteins may offer antibiotic alternative
Date:11/20/2011

t 24 hours post administration.
  • When given shortly after the animals were infected with E. coli O157:H7 but before they developed active disease, the Avidocin protein inhibited bacterial colonization and/or the symptoms of infection. Animals that received the highest dose of protein studied did not develop diarrhea at any time during the experiment. In contrast, animals given buffer alone developed typical diarrhea within 1-2 days after infection, which worsened by the 3rd day of the study.
  • Analyses of colon tissue showed less severe intestinal inflammation in Avidocin protein-treated animals compared to controls. Avidocin protein administration also greatly reduced the number of E. coli O157:H7 recovered from the intestine and the stool of treated animals.
  • When the anti-E. coli O157:H7 Avidocin protein was administered to infected animals already exhibiting disease symptoms, the existing diarrhea began to resolve in treated animals compared to animals treated with placebo. This reduction in diarrhea persisted until the experiment was terminated, 9 days post infection, at which time the feces of the treated animals appeared closer to feces from uninfected animals than the still largely liquid stool of the control animals. Thus, even after the onset of diarrhea in E. coli O157:H7-infected animals, administration of the anti-E. coli O157:H7 Avidocin protein could still mitigate the effects of infection.

    "These findings suggest that an Avidocin protein targeted against E. coli O157:H7 offers promise for both the prevention and treatment of infection by this important enteric pathogen," concluded Dr. Scholl. "Moreover, this agent provides several significant advantages over conventional antibiotics, including a lack of drug-induced shiga toxin production and unintended collateral damage to normal intestinal bacterial populations. Additionally those rare variants of E. coli O157:H7 that em
    '/>"/>


    • Contact: Joan Kureczka
    Joan@kureczka-martin.com
    415-821-2413
    Kureczka/Martin Associates
    Source:Eurekalert

    0

    GOOD

    Page: 1 2 3

    Related biology news :

    1. On the trail of a targeted therapy for blood cancers
    2. Cellular discovery may lead to targeted treatment for rare form of anemia
    3. Molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment
    4. Targeted drug therapy prevents exercise-induced arrhythmias
    5. Breakthrough in radiotherapy promises targeted cancer treatment
    6. Genetic finding could lead to targeted therapy for neuroblastoma
    7. New subtype of breast cancer responds to targeted drug
    8. Caltech-led team provides proof in humans of RNA interference using targeted nanoparticles
    9. UC to test targeted treatment for prostate cancer
    10. New mechanisms of tumor resistance to targeted therapy in lung cancer are discovered
    11. New targeted therapy adds benefit to erlotinib in some patients with advanced lung cancer
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:5/16/2013)... Illustrating a commitment to the support of underrepresented ... Research Foundation has announced the inaugural AGA Investing ... Supported by the National Institute of Diabetes and ... helps underrepresented minority students to further their research ... "By establishing this new award, AGA demonstrates its ...
    (Date:5/16/2013)... used ancient shorelines to predict the stability of today,s largest ... shoreline from three million years ago, for example when ... to be evidence of a high sea level due to ... many scientists to think that if the world,s largest ice ... the same in our modern, progressively warming world. , ...
    (Date:5/16/2013)... Philadelphia, PA, May 16, 2013 The relationship ... intelligence (IQ) has not been clear. Schizophrenia is ... functional disability. There are clues that reduced IQ ... schizophrenia. For example, reduced cognitive ability may precede ... may be present in healthy relatives of people ...
    Breaking Biology News(10 mins):Underrepresented minority students receive fellowships in digestive disease and nutrition research 2World's biggest ice sheets likely more stable than previously believed 2Genetic risk for schizophrenia is connected to reduced IQ 2
    ... upper end of the typical pain scale an ... is debilitating. Yet many sufferers do not get relief ... prescribed pain medications. Recently, a team of researchers ... engineering in CCNY,s Grove School of Engineering, has shown ...
    ... the equatorial Pacific by the end of the century, wreaking ... shows that climate change could cause ocean currents to operate ... islands right on the equator. Those islands include some ... Kiribati. This low-lying country is at risk from sea-level rise ...
    ... New research published online in the FASEB ... 5-lipoxygenase, plays a key role in cell death induced ... likely help prevent or lessen the severity of immune ... space conditions initiate health problems that mimic the aging ...
    Cached Biology News:Technology eases migraine pain in the deep brain 2Global warming refuge discovered near at-risk Pacific island nation of Kiribati 2Global warming refuge discovered near at-risk Pacific island nation of Kiribati 3Global warming refuge discovered near at-risk Pacific island nation of Kiribati 4Scientists discover enzyme that could slow part of the aging process in astronauts -- and the elderly 2
    (Date:5/20/2013)... 20, 2013 Interventional cardiologist Tony Farah, ... Hospital (AGH) Cardiovascular Institute have helped pioneer many ... disease (CAD) over the past three decades, from ... angioplasty and coronary artery stent implantation. , Today, AGH ... a prominent role in the study of a novel, ...
    (Date:5/20/2013)... France (PRWEB) May 20, 2013 On ... this time – in Paris - the beautiful city ... congress chairperson, "Personalized Medicine is revolutionizing the medical world. ... clinical knowledge is the hallmark of this transformation. Much ... care derived from the epidemiologic studies of large cohorts ...
    (Date:5/20/2013)... CA (PRWEB) May 20, 2013 The ... announced the appointment of Lisa Baird as Executive Director. ... July 8, 2013. The WMIS vision is ... applications to understand and effectively treat diseases in the ... Society (WMIS) was established in 2011 by integrating the ...
    (Date:5/17/2013)... 17, 2013 Topricin Pain Relief ... has been listed among nationally recommended over-the-counter (OTC) ... conducted by "U.S. News" Health in collaboration with ... “No. 1 Pharmacists Recommended designation” in the ... OTC brands, and is the only homeopathic formula ...
    Breaking Biology Technology:Allegheny General Hospital Cardiovascular Institute Becomes Exclusive Pittsburgh Site for Study of Novel Coronary Artery Disease Device 2Allegheny General Hospital Cardiovascular Institute Becomes Exclusive Pittsburgh Site for Study of Novel Coronary Artery Disease Device 3Allegheny General Hospital Cardiovascular Institute Becomes Exclusive Pittsburgh Site for Study of Novel Coronary Artery Disease Device 4The International Congress on Personalized Medicine - Up Close and Personalized 2013 in Paris 2WMIS Appoints Lisa Baird as Next Executive Director 2Pharmacists' Picks: Topical BioMedics' Topricin Listed on Top Recommended OTC Health Products 2
    ... BEIJING, June 29 /PRNewswire-Asia/ -- RainEarth Inc.,(OTC ... Company,s,Chinese subsidiary, Beijing Rain and Earth Technology Development Corp. ... for,Medicine and Health Products. , ... economy for medicine,and health products. In the forum, participants ...
    ... SHANGHAI, June 29 /PRNewswire-Asia/ -- WuXi PharmaTech (Cayman) Inc. (NYSE:, ... by China,s Ministry of Commerce,to the list of Top Ten ... Second Annual China International Service Outsourcing,Cooperation Conference, held in Nanjing ... (Logo: http://www.newscom.com/cgi-bin/prnh/20040705/CNM002LOGO ) , ...
    ... and VANCOUVER, June 26 /PRNewswire-FirstCall/ - OncoGenex Pharmaceuticals, Inc. ... has filed a shelf registration statement on Form S-3 ... MJDS prospectus under the multi-jurisdictional disclosure system in the ... us to re-establish a three-year shelf registration statement to ...
    Cached Biology Technology:RainEarth (RNER) Continues to Expand its Marketing Force in China 2RainEarth (RNER) Continues to Expand its Marketing Force in China 3WuXi PharmaTech Named a Top Ten Chinese Outsourcing Enterprise 2OncoGenex Pharmaceuticals Files Shelf Registration Statement 2OncoGenex Pharmaceuticals Files Shelf Registration Statement 3OncoGenex Pharmaceuticals Files Shelf Registration Statement 4
    ... Phosphatase-2A (PPase-2A) is a serine/threonine phosphatase isolated ... isolated as the heterodimer of 60kDa (A) ... ability to dephosphorylate the a-subunit of phosphorylase ... has broad substrate specificity and may play ...
    ... a high performance spectral scanning multimode ... With the advanced SkanIt Software it ... drug discovery assay development. Varioskan provides ... time-resolved fluorescence and photometric assays and ...
    ... a wide variety of solvent vapors that can contaminate ... (GCF400) allows for the collection of liquid into a ... minimizes waiting period., Ultra low -104 o ... , Digital Display of temperature ...
    Immulon 2HB, Flat Bottom, 50/Bx; high binding irradiated surface to provide increased binding affinity for hydrophilic proteins and complexes....
    Biology Products: