Navigation Links
Targeted antibacterial proteins may offer antibiotic alternative
Date:11/20/2011

t 24 hours post administration.
  • When given shortly after the animals were infected with E. coli O157:H7 but before they developed active disease, the Avidocin protein inhibited bacterial colonization and/or the symptoms of infection. Animals that received the highest dose of protein studied did not develop diarrhea at any time during the experiment. In contrast, animals given buffer alone developed typical diarrhea within 1-2 days after infection, which worsened by the 3rd day of the study.
  • Analyses of colon tissue showed less severe intestinal inflammation in Avidocin protein-treated animals compared to controls. Avidocin protein administration also greatly reduced the number of E. coli O157:H7 recovered from the intestine and the stool of treated animals.
  • When the anti-E. coli O157:H7 Avidocin protein was administered to infected animals already exhibiting disease symptoms, the existing diarrhea began to resolve in treated animals compared to animals treated with placebo. This reduction in diarrhea persisted until the experiment was terminated, 9 days post infection, at which time the feces of the treated animals appeared closer to feces from uninfected animals than the still largely liquid stool of the control animals. Thus, even after the onset of diarrhea in E. coli O157:H7-infected animals, administration of the anti-E. coli O157:H7 Avidocin protein could still mitigate the effects of infection.

    "These findings suggest that an Avidocin protein targeted against E. coli O157:H7 offers promise for both the prevention and treatment of infection by this important enteric pathogen," concluded Dr. Scholl. "Moreover, this agent provides several significant advantages over conventional antibiotics, including a lack of drug-induced shiga toxin production and unintended collateral damage to normal intestinal bacterial populations. Additionally those rare variants of E. coli O157:H7 that em
    '/>"/>


  • Contact: Joan Kureczka
    Joan@kureczka-martin.com
    415-821-2413
    Kureczka/Martin Associates
    Source:Eurekalert

    Page: 1 2 3

    Related biology news :

    1. On the trail of a targeted therapy for blood cancers
    2. Cellular discovery may lead to targeted treatment for rare form of anemia
    3. Molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment
    4. Targeted drug therapy prevents exercise-induced arrhythmias
    5. Breakthrough in radiotherapy promises targeted cancer treatment
    6. Genetic finding could lead to targeted therapy for neuroblastoma
    7. New subtype of breast cancer responds to targeted drug
    8. Caltech-led team provides proof in humans of RNA interference using targeted nanoparticles
    9. UC to test targeted treatment for prostate cancer
    10. New mechanisms of tumor resistance to targeted therapy in lung cancer are discovered
    11. New targeted therapy adds benefit to erlotinib in some patients with advanced lung cancer
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:1/22/2015)... , Jan. 22, 2015 Infinisource has launched its new ... G2 model. The G2 sets a higher standard for collecting ... capital management solution. With plug-and-play installation, touch screen interface and ... provides a robust time collection solution for the small to ...
    (Date:12/22/2014)... Dec. 22, 2014 Research and Markets ... the "The Global Watermarking and Fingerprinting Markets" ... http://photos.prnewswire.com/prnh/20130307/600769 This insight ... watermarking and fingerprinting markets. Watermarking aims to control ...
    (Date:12/19/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has ... America Perimeter Security Systems Market" report to their offering. ... North American perimeter security market is estimated to grow at ... U.S. market holds a larger share in this market, ...
    Breaking Biology News(10 mins):Infinisource's NXG series sets new time clock standard 2The Global Watermarking and Fingerprinting Markets 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3
    ... 2010 -- For centuries, hunters have imitated their avian prey ... calls. Now a team of physicists at Harvard University in ... bird song with a simple physical model made of a ... [could] build a simple device, which has minimal control but ...
    ... get a grip on the arms race between plant-eating insects ... a boost from new research by a University of Arizona ... Ecology . Noah Whiteman, an assistant professor in the ... miniature ecosystem consisting of a plant and a tiny fly ...
    ... STATION - Functional amino acids play a critical role in ... Texas AgriLife Research scientist. In a journal article appearing ... 1:31-37, 2010), Dr. Guoyao Wu, AgriLife Research animal nutritionist ... at Texas A&M University, calls for scientists to "think out ...
    Cached Biology News:Simple rubber device mimics complex bird songs 2Walk in the park yields biological treasure 2Walk in the park yields biological treasure 3Walk in the park yields biological treasure 4Walk in the park yields biological treasure 5AgriLife scientist: Functional amino acids regulate key metabolic pathways 2
    (Date:1/22/2015)... Selexis SA, a serial innovation company ... (RCBs) used for drug discovery to commercial manufacturing, announced ... Next-Generation Sequencing (NGS) data packages. The NGS ... by ensuring the integrity of the gene, validation of ...
    (Date:1/22/2015)... Calif. , Jan. 22. 2015  Varian Medical Systems (NYSE: ... software, has been honored for its commitment to sustainability with ... companies. Varian is the highest ranked healthcare equipment company among ... today during the World Economic Forum at Davos, ...
    (Date:12/24/2014)...  United Therapeutics Corporation (NASDAQ: UTHR ) announced ... has submitted a pre-market approval application to the U.S. ... Medtronic,s SynchroMed ® II implantable drug infusion system ... Therapeutics, Remodulin ® (treprostinil) Injection delivered intravenously to ...
    (Date:12/24/2014)... (PRWEB) December 23, 2014 “Preparative ... Gas, HPLC, Flash), Consumables (Columns, Solvents, Buffers, Valves, ... Food & Agriculture) - Forecasts to 2019” provides ... challenges, opportunities, current market trends, and strategies impacting ...
    Breaking Biology Technology:Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Varian Honored Among World's 100 Most Sustainable Corporations 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4
    ... , , TUSTIN, Calif., Aug. 27 ... it will release its financial results for the first quarter of fiscal ... host a conference call and webcast to discuss the results at 11:30 ... senior management will discuss financial results for the first quarter ended July ...
    ... , , , SEATTLE, ... that the Company will hold an Analyst Day on Thursday, September 24, ... A live audio webcast of the presentation will be accessible through the ... are unable to listen to the live webcast, it will be archived ...
    ... , , , ... Aug. 27 Airo, recognized maker of the world,s best ... is available for delivery Q4 of 2009. Airo is releasing ... explosive environments like Petroleum, Chemicals, Fertilizer, Coal, Propane, Fuel Distribution, ...
    Cached Biology Technology:Peregrine Pharmaceuticals to Report First Quarter FY 2010 Financial Results 2Airo Wireless Announces the Release of the Intrinsically Safe A25is Cell Phone/PDA 2
    ...
    ... OrientExpress™ System Modules ... synthesis and directional cloning ... T7 expression vectors ... configuring OrientExpress™ Cloning Systems, ...
    ... While antigen and antibody-based immunoaffinity matrices, ... reused many times without compromising antigen-antibody ... and chaotropic agents has precluded the ... blotting. The CHEMICON Re-Blot Plus ...
    Applications: Western blotting ...
    Biology Products: