Navigation Links
Targeted antibacterial proteins may offer antibiotic alternative
Date:11/20/2011

t 24 hours post administration.
  • When given shortly after the animals were infected with E. coli O157:H7 but before they developed active disease, the Avidocin protein inhibited bacterial colonization and/or the symptoms of infection. Animals that received the highest dose of protein studied did not develop diarrhea at any time during the experiment. In contrast, animals given buffer alone developed typical diarrhea within 1-2 days after infection, which worsened by the 3rd day of the study.
  • Analyses of colon tissue showed less severe intestinal inflammation in Avidocin protein-treated animals compared to controls. Avidocin protein administration also greatly reduced the number of E. coli O157:H7 recovered from the intestine and the stool of treated animals.
  • When the anti-E. coli O157:H7 Avidocin protein was administered to infected animals already exhibiting disease symptoms, the existing diarrhea began to resolve in treated animals compared to animals treated with placebo. This reduction in diarrhea persisted until the experiment was terminated, 9 days post infection, at which time the feces of the treated animals appeared closer to feces from uninfected animals than the still largely liquid stool of the control animals. Thus, even after the onset of diarrhea in E. coli O157:H7-infected animals, administration of the anti-E. coli O157:H7 Avidocin protein could still mitigate the effects of infection.

    "These findings suggest that an Avidocin protein targeted against E. coli O157:H7 offers promise for both the prevention and treatment of infection by this important enteric pathogen," concluded Dr. Scholl. "Moreover, this agent provides several significant advantages over conventional antibiotics, including a lack of drug-induced shiga toxin production and unintended collateral damage to normal intestinal bacterial populations. Additionally those rare variants of E. coli O157:H7 that em
    '/>"/>


  • Contact: Joan Kureczka
    Joan@kureczka-martin.com
    415-821-2413
    Kureczka/Martin Associates
    Source:Eurekalert

    Page: 1 2 3

    Related biology news :

    1. On the trail of a targeted therapy for blood cancers
    2. Cellular discovery may lead to targeted treatment for rare form of anemia
    3. Molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment
    4. Targeted drug therapy prevents exercise-induced arrhythmias
    5. Breakthrough in radiotherapy promises targeted cancer treatment
    6. Genetic finding could lead to targeted therapy for neuroblastoma
    7. New subtype of breast cancer responds to targeted drug
    8. Caltech-led team provides proof in humans of RNA interference using targeted nanoparticles
    9. UC to test targeted treatment for prostate cancer
    10. New mechanisms of tumor resistance to targeted therapy in lung cancer are discovered
    11. New targeted therapy adds benefit to erlotinib in some patients with advanced lung cancer
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:7/11/2014)... DUBLIN , July 11, 2014 ... the "International Biometrics Technology Market - Industry Analysis ... report to their offering. ... attacks and crimes has created a need for high ... methods used for personnel authentication such as username and ...
    (Date:7/11/2014)... let nerve cells send out electrical signals, Johns Hopkins ... that may offer a new way to protect crops ... way. , Their findingthat naturally occurring insect toxins ... a closely related onesuggests that insecticides can be designed ... bees. A summary of the research, led by Frank ...
    (Date:7/11/2014)... Brazil- In the brains of all vertebrates, information ... an electric or chemical signal to be passed ... which are the most abundant type of synapse, ... is crucial for learning, memory, perception and cognition, ... critical for brain function. For instance, every ...
    Breaking Biology News(10 mins):International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3Blame it on the astrocytes 2
    ... into biofuel crops such as switchgrass and Miscanthus ... convert them into fuels. But many steps lead from the ... the growth of this new industry. A new computer model ... researchers say. The model can run millions of simulations, optimizing ...
    ... speakers for the New and Notable Symposium at the Society,s ... Notable Symposium highlights the latest and most exciting discoveries in ... by the Program Committee. Over 250 nominations were received this ... 2012, 10:45 AM to 12:45 PM in Ballroom 20D of ...
    ... characterise and classify the by-products that have the best ... consumption. Also participating in the project alongside AZTI-Tecnalia are ... Basque Foundation for Food Safety Elika, and Tecnalia,s Industrial ... Union,s Life+ Programme and co-funded by the Directorate for ...
    Cached Biology News:From field to biorefinery: Computer model optimizes biofuel operations 2From field to biorefinery: Computer model optimizes biofuel operations 3Biophysical Society announces New and Notable Symposium speakers 2Biophysical Society announces New and Notable Symposium speakers 3Biophysical Society announces New and Notable Symposium speakers 4Biophysical Society announces New and Notable Symposium speakers 5AZTI-Tecnalia researches the use of vegetable by-products for animal feed 2AZTI-Tecnalia researches the use of vegetable by-products for animal feed 3
    (Date:7/10/2014)... A recent study by researchers at the University ... the physical mechanisms governing the interplay of spin ... fundamental limits of ultrafast spintronic devices for data ... a charge as well as spin-angular momentum. In ... so there is no spin current," explained David ...
    (Date:1/15/2014)... an approach akin to assembling a club sandwich ... Technology (NIST) researchers have succeeded in crafting a ... flammability of foam commonly used in upholstered furniture ... the nanotube-coated polyurethane foam was reduced 35 percent ...
    (Date:1/15/2014)... 15, 2014  Bill Jacobs Automotive, a group of car dealerships ... with the Heartland Blood Center and offering free oil change ... takes place Saturday, Jan. 18 at the Bill Jacobs Cadillac ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The Bill ...
    (Date:1/15/2014)...   Niagara Thermal Products is proud to announce ... LLC ("B3") as the critical thermal component supplier in ... Army Corps of Engineers.  B3 has developed the only ... and destroys VOCs and other chemical pollutants, allergens and ...
    Breaking Biology Technology:University of Illinois study advances limits for ultrafast nano-devices 2Layered security: Carbon nanotubes promise improved flame-resistant coating 2Join the Bill Jacobs Auto blood drive and receive a free oil change 2Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2
    ... Murder and a Wrong Should be put ... Pardon" Giovanni Di Stefano, ROME, October 23 Giovanni Di ... Hawley Harvey Crippen. In,a letter supported by Dr John Trestrail who ... Secretary of State for,the pardon to be ,effective forthwith notwithstanding the ...
    ... MISSISSAUGA, ON, Oct. 22 /PRNewswire-FirstCall/ - YM BioSciences ... an oncology company that identifies,develops and commercializes differentiated ... of Directors has adopted a renewed,Shareholder Rights Plan ... fair treatment of shareholders in connection with any ...
    ... Cellmark Inc.,(Nasdaq: ORCH ), a leading worldwide ... it has signed a definitive purchase,agreement to acquire ... purchase price of $5.6 million in cash and ... common stock. The purchase price is,subject to adjustment ...
    Cached Biology Technology:YM Biosciences announces adoption of renewed Shareholders' Rights Plan 2YM Biosciences announces adoption of renewed Shareholders' Rights Plan 3Orchid Cellmark to Purchase ReliaGene Technologies, Inc. 2Orchid Cellmark to Purchase ReliaGene Technologies, Inc. 3
    Vertical Rack (five box vapor phase rack), includes 2.0" (5.1cm) boxes...
    ... and M.W. Turner (1997). • This ... used in the production of high-quality ... immunoassays, the standardisation of antibodies and ... amplification systems, enzyme immunoassays for detecting ...
    ... active MW: 34.2kDa Formulation: 10mM HEPES, ... 1mM dithiothreitiol with 50% glycerol Properites: ... the Certificate of Analysis for individual ... precipitation followed by gel filtration and ...
    MitoScreen (JC-1) Kit , 100 tests Consult technical datasheet for details....
    Biology Products: