Navigation Links
Targeted antibacterial proteins may offer antibiotic alternative
Date:11/20/2011

SOUTH SAN FRANCISCO, CA -- A novel antibacterial protein targeted against E. coli O157:H7 may offer a way to prevent or treat serious food-borne bacterial infections, as demonstrated in a study published in the December issue of Antimicrobial Agents and Chemotherapy. Results in an animal model of E. coli infection showed that the orally administered protein, developed by AvidBiotics, Inc., could prevent or treat E. coli O157:H7-induced diarrhea and intestinal inflammation when administered either on a preventative basis or after the onset of diarrhea. Moreover, animals treated with the protein also carried and shed fewer of the E. coli O157:H7 bacteria in their feces.

"E. coli O157:H7 contamination of foods like ground meats or produce is a well-publicized public health problem, with life-threatening infection outbreaks reported around the world in recent years," said Dean Scholl, Ph.D., lead author of the publication. "Antibiotics are contraindicated for patients infected with enterohemorrhagic E. coli (EHEC) strains like O157:H7, because many of those drugs induce the bacteria to produce and release harmful toxins. Anti-diarrheal medications also do not benefit infected patients, as they cause the bacteria to be retained in the intestines, leading to greater toxin exposure. Thus the successful development of treatments that can prevent infection or limit symptoms and disease duration and the possible further spread of harmful bacteria without increasing toxin release could benefit both individual patients and affected communities."

The study published by Dr. Scholl and his collaborators at AvidBiotics and Brigham and Women's Hospital/Harvard Medical School assessed AvidBiotics' anti-E. coli O157 protein, termed an Avidocin protein, in a rabbit model of infection and reported that:

  • The Avidocin protein remained active within the treated animals' intestinal tract for at leas
    '/>"/>

Contact: Joan Kureczka
Joan@kureczka-martin.com
415-821-2413
Kureczka/Martin Associates
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. On the trail of a targeted therapy for blood cancers
2. Cellular discovery may lead to targeted treatment for rare form of anemia
3. Molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment
4. Targeted drug therapy prevents exercise-induced arrhythmias
5. Breakthrough in radiotherapy promises targeted cancer treatment
6. Genetic finding could lead to targeted therapy for neuroblastoma
7. New subtype of breast cancer responds to targeted drug
8. Caltech-led team provides proof in humans of RNA interference using targeted nanoparticles
9. UC to test targeted treatment for prostate cancer
10. New mechanisms of tumor resistance to targeted therapy in lung cancer are discovered
11. New targeted therapy adds benefit to erlotinib in some patients with advanced lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2014)... Utah , Dec. 4, 2014  Tute Genomics, ... raised $2.3 million in Series A1 funding led by ... investors also participated in the investment round. ... the healthcare community adopts next-generation sequencing and seeks new ... said Reid Robison , MD MBA, and CEO ...
(Date:12/3/2014)... , Dec. 2, 2014   Marvin Test ... innovative test solutions for military, aerospace, and manufacturing ... of its successful TS-900 PXI semiconductor test ... features of high-end systems to customers at a ... compared to traditional ATE. "Our ...
(Date:11/21/2014)... November 18, 2014 According to ... by Systems (Video, RFID, Access Control, Intrusion Detection, Parking ... Banks, Government), Component Service Geography - Global Forecasts to ... is projected to be around $25 Billion in 2014 ... growing at a CAGR of 8.69%. Browse ...
Breaking Biology News(10 mins):Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3
... for drinking water but about 20 years ago the once ... toxic blue-green algae which can damage the liver, intestines and ... Knoxville, will be working on an international team funded by ... resolve the ecosystem balance in the lake. Their work could ...
... This press release is available in Spanish . ... scientist has found a "green" alternative to a type ... the accumulation of heavy metals in waterways. Ornamental ... copper and zinc. But fertilizers that provide these micronutrients ...
... dietary fats are not created equal. Some types of fats have ... like those often found in plants and fish, have well documented ... destructively to some fats but not others? A new ... Biology suggests the answer may lie in how different fats ...
Cached Biology News:University of Tennessee Team receives NSF support to study toxic water in China 2A greener way to fertilize nursery crops 2The Quarterly Review of Biology: Why some fats are worse than others 2
(Date:12/19/2014)... MA (PRWEB) December 19, 2014 Charm ... MRLAFMQ test for the Detection of Aflatoxin M1 in ... to receive independent third party validation. The peer reviewed ... Unit of the Institute for Agricultural and Fisheries Research ... Group. , Aflatoxin B1, the most toxic aflatoxin ...
(Date:12/19/2014)... 2014 Naurex Inc., a biopharmaceutical company leveraging ... of the central nervous system, today announced that ... will present at the 33 rd annual J.P. ... at 3:00 p.m. PST on Tuesday, January 13, 2015, ... Francisco, Calif. About Naurex ...
(Date:12/19/2014)... Calif. , Dec. 19, 2014 Bina Technologies, ... USA) announced today that they have been acquired by ... is a privately held company that provides a ... next generation sequencing (NGS) data for the academic and ... Roche Sequencing Unit, and will continue to focus on ...
(Date:12/19/2014)... 2014 Research and Markets ( ... "Technology Innovations in Smart Fabrics (Technical Insights)" ... http://photos.prnewswire.com/prnh/20130307/600769 The Research ... a detailed assessment on technological advancements and market ... 1. The Smart Fabrics market is ...
Breaking Biology Technology:Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3Technology Innovations in Smart Fabrics (Technical Insights) 2
... to innovation, American Family Insurance's Information Services Division ... The direction comes from within, and Byrne Chapman, vice president ... familiar phrase: nothing ventured, nothing gained. To build a culture ... modeled after employee-driven, quality-control programs. , ,While management experts ...
... plans to erect as many as five more buildings on ... about needs well beyond its existing base of 2,500 employees, ... administrative officer, said the company anticipates adding 1,500 more individual ... 2,500. In addition, there remains plenty of room on the ...
... protection firms could be the answer to a question you ... ,The Internet does connect you with your customers - and ... that could damage your reputation and sales. Here are several ... simple to the sophisticated, and suggestions for dealing with them. ...
Cached Biology Technology:CIO Leadership Series: Byrne Chapman, American Family Insurance 2CIO Leadership Series: Byrne Chapman, American Family Insurance 3CIO Leadership Series: Byrne Chapman, American Family Insurance 4Epic Systems will build well beyond current staff size 2Protecting your business against online brand abuse 2Protecting your business against online brand abuse 3
SDS-OutT Precipitation Reagent...
... Removal , , Removes ... cross-reactivity with other proteins , Simple, just ... Economical new surface technology, not based on ... with protein analysis. SurfactAway offers a simple ...
... speed and excellent temperature uniformity. Protocols that ... can be run without any modifications. The ... for 48 or 96 wells. In addition, ... applications are available. The High Precision Smart ...
General description: MaxiSorp TM surface is ideal for arraying molecules with mixed hydrophilic/hydrophobic domains such as proteins ID clarifier: Maxisorp(tm) with lid...
Biology Products: