Navigation Links
Targeted antibacterial proteins may offer antibiotic alternative
Date:11/20/2011

SOUTH SAN FRANCISCO, CA -- A novel antibacterial protein targeted against E. coli O157:H7 may offer a way to prevent or treat serious food-borne bacterial infections, as demonstrated in a study published in the December issue of Antimicrobial Agents and Chemotherapy. Results in an animal model of E. coli infection showed that the orally administered protein, developed by AvidBiotics, Inc., could prevent or treat E. coli O157:H7-induced diarrhea and intestinal inflammation when administered either on a preventative basis or after the onset of diarrhea. Moreover, animals treated with the protein also carried and shed fewer of the E. coli O157:H7 bacteria in their feces.

"E. coli O157:H7 contamination of foods like ground meats or produce is a well-publicized public health problem, with life-threatening infection outbreaks reported around the world in recent years," said Dean Scholl, Ph.D., lead author of the publication. "Antibiotics are contraindicated for patients infected with enterohemorrhagic E. coli (EHEC) strains like O157:H7, because many of those drugs induce the bacteria to produce and release harmful toxins. Anti-diarrheal medications also do not benefit infected patients, as they cause the bacteria to be retained in the intestines, leading to greater toxin exposure. Thus the successful development of treatments that can prevent infection or limit symptoms and disease duration and the possible further spread of harmful bacteria without increasing toxin release could benefit both individual patients and affected communities."

The study published by Dr. Scholl and his collaborators at AvidBiotics and Brigham and Women's Hospital/Harvard Medical School assessed AvidBiotics' anti-E. coli O157 protein, termed an Avidocin protein, in a rabbit model of infection and reported that:

  • The Avidocin protein remained active within the treated animals' intestinal tract for at leas
    '/>"/>

Contact: Joan Kureczka
Joan@kureczka-martin.com
415-821-2413
Kureczka/Martin Associates
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. On the trail of a targeted therapy for blood cancers
2. Cellular discovery may lead to targeted treatment for rare form of anemia
3. Molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment
4. Targeted drug therapy prevents exercise-induced arrhythmias
5. Breakthrough in radiotherapy promises targeted cancer treatment
6. Genetic finding could lead to targeted therapy for neuroblastoma
7. New subtype of breast cancer responds to targeted drug
8. Caltech-led team provides proof in humans of RNA interference using targeted nanoparticles
9. UC to test targeted treatment for prostate cancer
10. New mechanisms of tumor resistance to targeted therapy in lung cancer are discovered
11. New targeted therapy adds benefit to erlotinib in some patients with advanced lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/8/2015)... , July 8, 2015  Trovagene, Inc. (NASDAQ: ... diagnostics, today announced the launch of a study ... Precision Cancer Monitoring℠ (PCM) technology for predicting response ... or a combination of the novel immunotherapy agents ... a PD-1 inhibitor. The 50-patient study will be ...
(Date:7/7/2015)... July 7, 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... growing mobile commerce market announces a revised version of one of ... commercial will air on CNBC in New York ... and San Francisco metro areas.    ... on Wocket,s ability to replace all the cards in your wallet ...
(Date:6/30/2015)... 30, 2015 To bolster its efforts and commitment ... announced today the addition of two new team members. ... advisor and David Raviv will act as head ... Corp.,s commitment to providing the most secure solutions for the ... co-founded Layer 7 Technologies, a provider of security and management ...
Breaking Biology News(10 mins):Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 2Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 4Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 2Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 3HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 2HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 3
... 17 October 2008 Singapore,s Prime Minister Lee Hsien ... technology and business to celebrate the opening of Fusionopolis, ... hub, Biopolis, opened five years ago. ... six phases, is the country,s icon for research in ...
... Property Inventory for Biometric Identity Management ... ... International,Inc. (OTC Bulletin Board: BKYI), a leader in finger-based biometric,identification and ... has approved the issuance of a patent for the,company,s "Biometric Identification ...
... gases from volcanic eruptions could have given rise to the ... samples from a classic origin-of-life experiment by NASA and university ... in Science appearing October 16. "Historically, you ... these; they re-defined our thoughts on the origin of life ...
Cached Biology News:Singapore opens Fusionopolis, its second major R&D hub in 5 years 2Singapore opens Fusionopolis, its second major R&D hub in 5 years 3Singapore opens Fusionopolis, its second major R&D hub in 5 years 4BIO-key(R) Granted Additional Patent for Biometric Security Solution 2BIO-key(R) Granted Additional Patent for Biometric Security Solution 3Volcanoes may have provided sparks and chemistry for first life 2Volcanoes may have provided sparks and chemistry for first life 3
(Date:7/30/2015)... , CA (PRWEB) , ... July 30, 2015 ... ... the successful completion of a field clinical study of its canine osteoarthritis stem ... together with Aratana Therapeutics (Kansas City, KS) and will be marketed in the ...
(Date:7/30/2015)... -- HIGHLIGHTS:Q2 2015 Results (all changes are ... sales were $697 million compared to $701 million in ... 8%, and changes in foreign currency exchange rates decreased ... , By business unit, organic sales growth was ... SAFC Commercial. , Reported diluted EPS was $0.98 ...
(Date:7/29/2015)... Sanofi, un leader mondial ... pour le premier semestre 2015. Le Directeur Général ... Visionner l,interview vidéo et lire la transcription ... Au sommaire de l,interview :  - ... - Diabète - Praluent ...
(Date:7/29/2015)...  HealthSouth Corporation (NYSE: HLS ), ... healthcare services, offering both facility-based and home-based post-acute ... the second quarter ended June 30, 2015. ... volume growth in both segments and an 11.0% ... President and Chief Executive Officer of HealthSouth. "While ...
Breaking Biology Technology:VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 3Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 2Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 3Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 4Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 5Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 6Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 7Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 8Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 9Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 10Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 11Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 12Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 13Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 14Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 15Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 16Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 17Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 18Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 19Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 20HealthSouth Reports Results for Second Quarter 2015 2HealthSouth Reports Results for Second Quarter 2015 3HealthSouth Reports Results for Second Quarter 2015 4HealthSouth Reports Results for Second Quarter 2015 5HealthSouth Reports Results for Second Quarter 2015 6HealthSouth Reports Results for Second Quarter 2015 7HealthSouth Reports Results for Second Quarter 2015 8HealthSouth Reports Results for Second Quarter 2015 9HealthSouth Reports Results for Second Quarter 2015 10HealthSouth Reports Results for Second Quarter 2015 11HealthSouth Reports Results for Second Quarter 2015 12HealthSouth Reports Results for Second Quarter 2015 13HealthSouth Reports Results for Second Quarter 2015 14HealthSouth Reports Results for Second Quarter 2015 15
... Myriant Technologies LLC (Myriant), a privately-held, biotech developer ... of its Science Advisory Board and the appointment ... collectively will provide broad insight into all aspects ... biomass feedstocks into valuable chemicals. , (Logo: ...
... ... capture investors, interest. , ... Miami, FL (PRWEB) October 21, 2009 -- iLife Americas, LLC, a leading developer ... U.S. to market its line of iLife wellness and therapeutic products. Officially opened on ...
... /PRNewswire-Asia-FirstCall/ -- China Medical Technologies,Inc. (the "Company") (Nasdaq: CMED ... markets advanced in-vitro diagnostic,products, today announced that it will attend ... to October 31, 2009 in Chengdu,China. , , ... 62nd China International Medical Equipment Fair, Date: ...
Cached Biology Technology:Myriant Technologies LLC Announces Appointment of Science Advisory Board Members 2Myriant Technologies LLC Announces Appointment of Science Advisory Board Members 3iLife Americas, LLC Enters U.S. Wellness and Therapeutic Markets 2China Medical Technologies to Exhibit its Products at China International Medical Equipment Fair in Chengdu, China 2
... The Fujifilm Life Science FLA-5100 imaging ... samples as large as 40 x 46cm ... 10 microns. This system is especially suitable ... and general array analysis for genomics., Fuji ...
... The new FLA-5000 imaging system ... radioisotopic samples as large as ... as low as 25 microns. ... for protein electrophoresis in the ...
... The Caliper Sciclone ALH 3000 workstation automates ... applications, from Genomic and Proteomic Sample Preparation ... The modular design of the Caliper ... and accessories to perfectly meet the needs ...
Designed for use with the Agencourt SprintPrep 384 kit and all MCPrep reagent kits. Used with flat bottom 96-well microplates such as deep well plates used to culture bacteria....
Biology Products: