Navigation Links
Target: Cancer
Date:2/26/2013

For scientists to improve cancer treatments with targeted therapeutic drugs, they need to be able to see proteins prevalent in the cancer cells. This has been impossible, until now. Thanks to a new microscopy technique, University of Akron researcher Dr. Adam Smith, assistant professor of chemistry, has observed how clusters of epidermal growth factor receptor (EGFR) a protein abundant in lung and colon cancers, glioblastoma and others malfunctions in cancer cells.

"We can directly observe protein clusters, in a living cell membrane, that are invisible to traditional methods. This opens up the possibility to directly measure the effect of drugs on the target proteins," Smith says.

Smith's work lies at the heart of current-day cancer research, which focuses on developing targeted drugs that kill cancer cells without the collateral damage associated with traditional treatments like chemotherapy.

Specifically, Smith used a cutting-edge photon-counting technique, which enables scientists to measure the cluster size of EGFR proteins. The technique represents a significant advancement from studying the cultures with a traditional microscope, which cannot visually capture objects as small as the EGFR clusters, according to Smith, a lead author of "Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor," published in the Jan. 31 journal Cell, which highlights the technique.

"Another difficulty with studying EGFR is that it's located in the cell membrane, which can be thought of as a fence line that defines the cell boundary, but in reality it is more like an untamed hedge row," says Smith, explaining how the new laser-based microscope technique overcomes that obstacle and allows scientists to study, in real time, how EGFR works in healthy cells and also how it malfunctions in cancer cells.

Smith's subsequent work studying the interaction of drugs with the targeted EGFR "will significantly improve drug discovery, which too often relies on indirect measure of efficacy," he says.


'/>"/>

Contact: Denise Henry
henryd@uakron.edu
330-972-6477
University of Akron
Source:Eurekalert

Related biology news :

1. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
2. Embryonic development protein active in cancer growth
3. BRG1 mutations confer resistance to hormones in lung cancer
4. Genetic variation in East Asians found to explain resistance to cancer drugs
5. Beyond the microscope: Identifying specific cancers using molecular analysis
6. Marshall University study may lead to new treatments for prostate cancer
7. Salk scientists open new window into how cancers override cellular growth controls
8. Penn research points to new way of preserving fertility for boys undergoing cancer treatment
9. Genetic abnormality offers diagnostic hope for childrens cancer
10. Protein jailbreak helps breast cancer cells live
11. Breast cancer risk gene discovery fast tracked by new technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/7/2017)... 2017   HireVue , the leading provider of ... the best talent, faster, today announced the additions of ... and Diana Kucer as Chief Marketing Officer ... team poised to drive continued growth in the company,s ... of record bookings in 2017. "Companies worldwide ...
(Date:3/2/2017)... , March 2, 2017 Summary ... better understand Merck KGaA and its partnering interests and ... https://www.reportbuyer.com/product/3605601/ Description The Partnering Deals and Alliance ... partnering activity of one of the world,s leading life ... prepared upon purchase to ensure inclusion of the most ...
(Date:3/1/2017)... -- Aware, Inc. (NASDAQ: AWRE), a leading supplier of biometrics ... has resigned, effective March 3, 2017, as co-Chief ... Treasurer of Aware citing a desire to retire.  Mr. ... the Board of Directors of Aware. ... co-President, General Counsel has been named Chief Executive Officer, ...
Breaking Biology News(10 mins):
(Date:3/20/2017)... ... ... SSCI and Whitehouse Laboratories, divisions of Albany Molecular Research, Inc, are looking ... Drug Association (PDA), the New York Interphex Show will open on March 21 and ... 625 exhibitors, the educational and networking opportunities are extremely valuable. INTERPHEX is viewed as ...
(Date:3/20/2017)... New York City, NY (PRWEB) , ... March ... ... pressure vessels and equipment for pharmaceutical and biotech companies, recently announced it will ... Javits Center in New York City. The intelliVessel is controlled by a touch ...
(Date:3/20/2017)... ... March 20, 2017 , ... ... sample preparation methods in order to reduce the impact on instrumentation. ICP-MS is ... area of elemental analysis. , This presentation will discuss the pros and ...
(Date:3/20/2017)... ... March 20, 2017 , ... The fourth annual ... innovating to make an extraordinary impact on peoples’ lives, launches today. Sponsored by ... every 5 weeks and awards thousands in cash prizes to engineers, inventors and tinkerers ...
Breaking Biology Technology: