Navigation Links
Target 2 forms of iron to control cystic fibrosis lung infection
Date:8/19/2013

n-targeting therapies.

They tested sputum samples from a cross-section of 33 cystic fibrosis patients from the US and Belgium. Fe(II) was, indeed, abundant in the lungs of cystic fibrosis patients, and it comprised a considerable amount of the total iron in each sample, confirming the authors' suspicions. What's more, sicker patients had greater quantities of Fe(II), and while Fe(II) concentration was significantly correlated with disease the concentration of Fe(III) was not.

The authors also tested whether inhibiting the uptake of Fe(II) or Fe(III) - or both - would prevent biofilm formation. Using a high-throughput biofilm assay in the lab, they tested the ability of ferrozine, an Fe(II)-specific chelator, and conalbumin, a Fe(III)-specific chelator, to bind iron and prevent the buildup of a biofilm. They found that in a system where both Fe(II) and Fe(III) are present, as they are in the lungs of cystic fibrosis patients, it was most effective to apply both types of chelators: sequestering both forms of iron resulted in a 58% reduction in biofilm accumulation. This suggests that for treating patients, targeting both forms of iron might be more effective than targeting Fe(III) alone.

"Collectively, these studies underscore the importance of a dialectic between laboratory and environmental studies of pathogens such as P. aeruginosa," write the authors. Mechanistic studies of microorganisms in the laboratory can only go so far without real-world information about the chemical conditions under which they live in the human body. The integrated approach used in this study has provided a superior understanding of how iron availability might be manipulated to prevent biofilm formation and can inform the effective design and application of therapeutic strategies for treating P. aeruginosa biofilms.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Collaborative preclinical efficacy studies suggest a new target for drug addiction treatment
2. Crestor Delivers Latest LDL-C Targets in High-Risk Patients at Lower Doses than Other Statins
3. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
4. Nanobubbles plus chemotherapy equals single-cell cancer targeting
5. Researchers identify Achilles heel of dengue virus, target for future vaccines
6. Scientists identify FLT3 gene as a valid therapeutic target in acute myeloid leukemia
7. Genetically modified corn affects its symbiotic relationship with non-target soil organisms
8. Unique adaptations to a symbiotic lifestyle reveal novel targets for aphid insecticides
9. Yeast cell reaction to Zoloft suggests alternative cause, drug target for depression
10. Key proteins newly discovered form and function may provide novel cancer treatment target
11. Scientists discover new inflammatory target
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... Nov. 4, 2014   Neurotechnology , a ... that the latest version of its fingerprint matching ... Ongoing MINEX evaluation organized by NIST. The ... using the INCITS 378 fingerprint standard template format. ... public tenders in the United States ...
(Date:11/3/2014)... study published in this month,s Proceedings of ... of a recently discovered communication molecule of the body,s ... known to limit inflammation and the current study reports ... the ability of the immune system to recognize and ... IL-37,s effect on the immune system now allows us ...
(Date:11/3/2014)... Researchers from Australia report that low birth weight and ... (OA)-related hip replacements in adulthood. Findings published in the ... & Research , indicate that low birth weight and ... arthroplasty due to OA as adults. , According ... of 25 are diagnosed with clinical OA. Symptoms of ...
Breaking Biology News(10 mins):Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3PNAS: From HIV to cancer, IL-37 regulates immune system 2Preterm, low birth-weight babies may need new hips in adulthood 2
... WI, JUNE 30, 2011 -- Agroforestry, the deliberate placement ... capture substantial amounts of carbon on agricultural lands while ... tools for accurately estimating current and projected carbon values ... an effective carbon-capturing option. Only occupying about 2 to ...
... scientific results from an ambitious voyage led by a group ... San Diego offer a stark view of human pollution and ... been labeled as the "Great Pacific Garbage Patch." Two ... or SEAPLEX, found evidence of plastic waste in more than ...
... HFES invites you to register to attend the 55th ... Red Rock Hotel in Las Vegas! Early bird discounts ... the Registration Information page at http://www.hfes.org/web/HFESMeetings/2011registration.html for ... more. Online registration is available at http://tinyurl.com/3drb8hz . ...
Cached Biology News:Scripps study finds plastic in 9 percent of 'garbage patch' fishes 2Scripps study finds plastic in 9 percent of 'garbage patch' fishes 3HFES 2011 registration is now open 2
(Date:11/21/2014)... November 20, 2014 Author Matthew J. ... to the Other Side” published as a tribute ... in the “Fiction: Short Story” category of the ... President and CEO of USA Book News, said this ... independent publishers, including Simon & Schuster, Penguin, John Wiley ...
(Date:11/21/2014)... York, NY (PRWEB) November 20, 2014 ... is now available as an open access journal featuring ... with infrared fluorescent proteins to preserve photoresponsiveness in the ... Two-color fluorescent in situ hybridization using chromogenic substrates ... chips for DNA, RNA, and protein electrophoresis , ...
(Date:11/21/2014)... 21, 2014 2014 Deep Research ... is a professional and in-depth research report on ... information, like its definition, classification, application, and ... This report covers the international market analysis, including ... as the US, Europe, Asia, China, Japan etc. ...
(Date:11/21/2014)... /CNW/ - Aequus Pharmaceuticals Inc. (the "Company" or ... closed a brokered private placement offering (the "Brokered ... Cormark Securities Inc. and Clarus Securities Inc. acted ... a syndicate of agents that also included Wolverton ... "Agents"). Concurrently with the Brokered Offering, the Company ...
Breaking Biology Technology:Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 2Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 4BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3Aequus Pharmaceuticals closes $4.2 million private placement financing 2Aequus Pharmaceuticals closes $4.2 million private placement financing 3
... - So you want to start a business? ... you begin? , ,The idea usually comes first. Is it ... forming a business entity, protecting this commercial idea is critical ... what type of intellectual property is this? Patentable? Copyrightable? Trade ...
... of the world's most powerful supercomputers are used ... as little surprise to the Wisconsin companies operating ... , ,However, while information technology is extremely important ... instruments for manufacturing and analysis, enterprise resource planning ...
... after taking the helm at the WiCell Research Institute ... private sector, the organization announced. , ,Donley, who was serving ... to WiCell's parent, the Wisconsin Alumni Research Foundation , ... ,Donley, who joined WARF in 1998, indicated that she would ...
Cached Biology Technology:Starting a tech business? Step 1 is minding the intellectual property 2Starting a tech business? Step 1 is minding the intellectual property 3Proceeding with caution at corner of IT & biotech 2Proceeding with caution at corner of IT & biotech 3Proceeding with caution at corner of IT & biotech 4Donley resigns as WiCell director 2
Glycerokinase; from Bacillus stearothermophilus...
A compact, high-speed single tube reader unit designed for benchtop 2D barcode reading. The unit can be used with all of ABgene's 2D barcoded tubes, including the 2ml CryoCode tube....
... Fluoroskan Ascent FL ... fluorometric and luminometric measurement ... long list of advanced ... and Luminoskan Ascent. Fluoroskan ...
... a hydrolytic enzyme that catalyzes the ... glucose, maltose, maltotriose and,dextrins. The level ... the human,body are of clinical importance,1-3 ... enzymes for industry.4, The EnzChek Amylase ...
Biology Products: