Navigation Links
Tamiflu-resistant influenza: Parsing the genome for the culprits
Date:3/31/2014

enomenon, and other mutations."

New resistant mutations are discovered

To begin, the team led by Jensen and his colleague Matthieu Foll cultured ordinary H1N1 virus in the laboratory. Certain groups were subjected to Tamiflu, others not. Every 48 hours 13 generations the biologists sequenced the virus' genome to reveal the genetic mutations that had occurred in the interval.

The more the genetic mutations of viruses exposed to Tamiflu tended to become prevalent with time, the higher the probability that they would confer resistance. With a complex statistics-based software tool, the researchers were able to pinpoint 12 sites on the viral genome that carried suspect variations. One of these was already known, but the rest had not yet been identified.

Weeding out the resistance-conferring mutations

Using their statistical software, the researchers were able to comb through the immensity of the viral genetic code and identify only the mutations that were suspected to cause resistance, with a certainty of more than 99% - making their software a powerful tool indeed.

And these newly discovered mutations are reason for concern: they could allow the virus to be resistant while maintaining an elevated reproductive capacity. Jensen thus doesn't exclude the possibility that pathogenic strains could appear that are both competitive and Tamiflu-resistant, if the mistake of 2008-2009 is repeated. For Foll, first author on the study, "the risk is real, and we need to investigate further."


'/>"/>

Contact: Lionel Pousaz
lionel.pousaz@epfl.ch
41-795-597-161
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert

Page: 1 2

Related biology news :

1. Better preparedness against Tamiflu-resistant influenza viruses
2. H7N9 influenza: History of similar viruses gives cause for concern
3. Research from CHORI scientists demonstrates first genome methylation in fruit fly
4. Genome-wide association studies mislead on cardiac arrhythmia risk gene
5. In the genome of loblolly pine lies hope for better resistance to a damaging disease
6. Loblolly pine genome is largest ever sequenced
7. Loblolly pines immense genome conquered
8. Newly identified small-RNA pathway defends genome against the enemy within
9. The genome of sesame sheds new lights on oil biosynthesis
10. Scripps Wellderly Genome Resource now available to researchers
11. Pond-dwelling powerhouses genome points to its biofuel potential
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/19/2014)... in India over the last 30 years contributed ... growth during that time, according to a new ... Change ., "Energy access is fundamental to development: ... including education, communication, and health," says IIASA researcher ... increased energy access is widely agreed to be ...
(Date:10/18/2014)... patients with undiagnosed, suspected genetic conditions, a certain type ... molecular diagnostic yield than traditional molecular diagnostic methods, according ... study is being released to coincide with the American ... which sequences the protein­coding region of the genome (the ... a cell or organism), has been rapidly applied in ...
(Date:10/17/2014)... University of Copenhagen have shown for the first time ... Cystic fibrosis patients, giving them the opportunity to get ... infections. , The study also discovered the bacterial growth ... was halted or slowed down by the immune cells. ... oxygen and helped "suffocate" the bacteria, forcing the bacteria ...
Breaking Biology News(10 mins):Improved electricity access has little impact on climate change 2Study examines type of exome sequencing and molecular diagnostic yield 2Study examines type of exome sequencing and molecular diagnostic yield 3Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2
... Bacteria in the human gut may not just be helping ... control over the metabolic functions of other organs, like the ... journal mBio . These findings offer new understanding of ... how changes to the microbiota can impact overall health. ...
... the silk moth,s antenna, University of Michigan researchers led ... that could advance understanding of a class of neurodegenerative ... work is newly published online in Nature Nanotechnology ... associate professor in the U-M departments of Biomedical Engineering ...
... Science fiction novelist and scholar Issac Asimov once said, ... that heralds new discoveries, is not ,Eureka!, but ,That,s funny., ... of researchers when they observed something they did not expect. ... of the Week," the Berlin-based team reports that it has ...
Cached Biology News:Gut bacteria can control organ functions 2Silk moth's antenna inspires new nanotech tool with applications in Alzheimer's research 2Researchers develop curious snapshot of powerful retinal pigment and its partners 2Researchers develop curious snapshot of powerful retinal pigment and its partners 3
(Date:10/22/2014)... and HONG KONG , Oct. ... disease therapeutics enterprise, announced today that rare disease expert ... as vice president, research. Dr. McKew brings more than ... leadership positions at the National Institutes of Health, Wyeth ... by Wyeth). Dr. McKew will lead aTyr,s efforts to expand ...
(Date:10/20/2014)... 2014 Mapp Biopharmaceutical,s valiant effort to ... to fight the Ebola outbreak will make the ... production of pharmaceuticals can be, according to Kalorama ... while some may be taken aback by the ... industry knowledge are well aware of the complex ...
(Date:10/20/2014)... MENLO PARK, Calif. , Oct. 20, 2014 ... announced today that the Company has signed a ... Institute of Regenerative Medicine (CIRM), effective October 1, ... of Clinical Development payments and the release of ... $14.3 million CIRM grant award for clinical development ...
(Date:10/20/2014)... , October 20, 2014 , ... (GI) disorders and the delivery of care has revealed ... and worrying inequalities in the provision of healthcare services ... was commissioned by United European Gastroenterology (UEG), have been ... and public awareness of the burden of GI disorders ...
Breaking Biology Technology:aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5
... . - Radio frequency identification technology is often touted as ... health care world, the technology is bringing other, perhaps more ... on the supply chain now, and there are tremendous applications ... natural in the marketplace," said Reik Read, an analyst with ...
... IT businesses, according to market research firm Gartner, Inc. ... their key roles transformed. Ten percent will have closed their ... commodity status. , ,The predictions were made this week at ... changes are being driven by maturing IT applications and the ...
... Chippewa Valley Technical College in Eau Claire are offering ... surface analysis to firms or organizations with an economic ... three students will comprise each of five teams with ... that firms considering the purchase of an electron microscope ...
Cached Biology Technology:RFID can be a matter of life and death in the medical world 2RFID can be a matter of life and death in the medical world 3RFID can be a matter of life and death in the medical world 4RFID can be a matter of life and death in the medical world 5Radical changes predicted for IT groups 2