Navigation Links
Talking to cells
Date:6/5/2008

This release is available in German.

For an organism to develop and function, the individual cells must exchange information, or communicate, with each other. Is it possible to learn their language and "talk to" the cells? Yes it is: Cameron Alexander and George Pasparakis at the University of Nottingham (UK) have been able to facilitate a conversation between bacterial cells and artificial polymer vesicles. In the journal Angewandte Chemie they report that this first communication occurred by way of sugar groups on the vesicle surface. The vesicles subsequently transfer information to the cellsin the form of dye molecules.

Complex structures made of many sugar components on the surfaces of cells are the "language" used for processes such as cell recognition, for example, in the differentiation of tissues or the identification of endogenous cells and foreign invaders. Scientists would like to be able to use this glycocode to "address" target cells and to intervene directly in cellular processes to treat diseases or to guide regeneration of damaged tissues.

The British scientists took an interesting route to learn more about the "language" of cells: they constructed vesicles, tiny capsules whose outer shell is made of special polymer building blocks. Their special trick: the polymer chains are equipped with side chains bearing glucose units that wind up being exposed on the vesicle surface.

The researchers brought the vesicles together with bacteria that have glucose-binding proteins on their surface. The behavior of the bacteria varies depending on the polymer's composition and the size of the vesicles. Among the bacteria were some individuals that enter into very strong bonds with large vesicles. These associated bacteria are then in a position to receive molecular "information" from the vesicles: dye molecules that were previously placed in the vesicles transferred specifically into the interior of these bacteria.

"Our vesicles can be viewed as simple replicas of living cells," says Alexander, "that can communicate with real cells by way of the glycocode as well as through signal molecules inside the vesicles." Possible applications include drug transporters that deliver their cargo to specific target cells, or antibiotic transporters that deliver their toxic load exclusively to infectious agents.


'/>"/>

Contact: Cameron Alexander
cameron.alexander@nottingham.ac.uk
44-115-846-7678
Wiley-Blackwell
Source:Eurekalert  

Related biology news :

1. ESF EURYI award winner aims to stop cancer cells reading their own DNA
2. Newly created cancer stem cells could aid breast cancer research
3. AIDS interferes with stem cells in the brain
4. Clemson scientists shed light on molecules in living cells
5. Social habits of cells may hold key to fighting diseases
6. UF scientists reveal how dietary restriction cleans cells
7. Human derived stem cells can repair rat hearts damaged by heart attack
8. Scientists identify embryonic stem cells by appearance alone
9. Cells united against cancer
10. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
11. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Talking to cells
(Date:6/22/2016)... 2016 On Monday, the Department of Homeland ... share solutions for the Biometric Exit Program. The Request ... Protection (CBP), explains that CBP intends to add biometrics ... the United States , in order to deter ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/9/2016)... in attendance control systems is proud to announce the introduction of fingerprint attendance control ... right employees are actually signing in, and to even control the opening of doors. ... ... ... Photo - ...
(Date:6/2/2016)... , June 2, 2016   The Weather Company ... announcing Watson Ads, an industry-first capability in which consumers will ... being able to ask questions via voice or text and ... Marketers have long sought an ... consumer, that can be personal, relevant and valuable; and can ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... NC (PRWEB) , ... June 27, 2016 , ... ... mission to bring innovative medical technologies, services and solutions to the healthcare market. ... and implementation of various distribution, manufacturing, sales and marketing strategies that are necessary ...
(Date:6/27/2016)... , June 27, 2016  Liquid Biotech ... the funding of a Sponsored Research Agreement with ... tumor cells (CTCs) from cancer patients.  The funding ... CTC levels correlate with clinical outcomes in cancer ... data will then be employed to support the ...
(Date:6/24/2016)... , June 24, 2016  Regular discussions on a range ... place between the two entities said Poloz. Speaking ... Ottawa , he pointed to the country,s inflation ... federal government. "In ... "Both institutions have common economic goals, why not sit down ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and ... and the 6000i models are higher end machines that use the more unconventional z-dimension ... light beam from the bottom of the cuvette holder. , FireflySci has developed ...
Breaking Biology Technology: