Navigation Links
Tales from the crypt lead researchers to cancer discovery
Date:3/30/2012

HUNTSVILLE, Ala Tales from the crypt are supposed to be scary, but new research from Vanderbilt University, the HudsonAlpha Institute for Biotechnology and colleagues shows that crypts can be places of renewal too: intestinal crypts, that is. Intestinal crypts are small areas of the intestine where new cells are formed to continuously renew the digestive tract. By focusing on one protein expressed in our intestines called Lrig1, the researchers have identified a special population of intestinal stem cells that respond to damage and help to prevent cancer.

The research, published in the March 30 issue of Cell, also shows the diversity of stem cells in the intestines is greater than previously thought.

"Identification of these cells and the role they likely play in response to injury or damage will help advance discoveries in cancer," said Shawn Levy, Ph.D., faculty investigator at the HudsonAlpha Institute and an author on the study.

The intestines and colon are normally lined with a single layer of cells to absorb nutrients from food. There are regular small pockets in the intestines called crypts, where stem cells are gathered. Rapid turnover of the lining cells and replacement by new lining cells made in the crypt, keep the intestines and colon healthy and keep damaged cells from turning into cancerous ones.

The new paper demonstrates that, although the makeup of stem cells in the crypt is still controversial, one protein called Lrig1 can distinguish a group of long-lived cells at the base of the crypt. These Lrig1-positive stem cells do not regularly replace lining cells, but instead are only activated when there is damage or injury to the intestine.

In addition, the researchers show that the Lrig1 protein functions to prevent cancer as a tumor suppressor molecule. When the protein is completely absent from a mouse model, the mice all develop adenomas and then tumors. This suggests that Lrig1 is an impor
'/>"/>

Contact: Chris Gunter or Holly Ralston
cgunter@hudsonalpha.org
256-327-0400
HudsonAlpha Institute for Biotechnology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genital stimulation opens door for cryptic female choice in tsetse flies
2. American Society for Microbiology honors Xiaorong Lin for work on Cryptococcus neoformans
3. Ecologists sound out new solution for monitoring cryptic species
4. This is your brain on Cryptococcus: Pathogenic fungus loves your brain sugar
5. Vancouver Island has one of the highest rates of Cryptococcus infection in the world
6. Improved Authentication and Confidentiality Protection. ICAP Patent Brokerage Announces for Auction Important Patents in Data Encryption and Document Security
7. NC State researchers get to root of parasite genome
8. Researchers find animal with ability to survive climate change
9. Researchers find an essential gene for forming ears of corn
10. Researchers note differences between people and animals on calorie restriction
11. Researchers study acoustic communication in deep-sea fish
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... , Dec. 09, 2014 Research and ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has ... in the APAC Region 2015-2019"  report to their ... in this market is advances in technology. With ... upgrade biometric solutions to the latest standard that ...
(Date:12/10/2014)... N.C. , Dec. 9, 2014  Valencell, a ... it is seeing a staggering demand from its licensees ... the Company revealed, is not solely coming from fitness ... as well. "A wearable is only as ... result, accuracy is the ultimate driver in long-term mass ...
(Date:12/5/2014)... MOUNTAIN VIEW, Calif. , Dec. 4, 2014 ... and safety has boosted investments in new testing ... products has also given rise to a range ... driven by the requirements of Generation Y, which ... digital technologies. As a result, product development strategies ...
Breaking Biology News(10 mins):Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4
... Sorority and the Orthopaedic Research and Education Foundation (OREF) ... to close the gap between basic research and patient ... of the American Academy of Orthopaedic Surgeons (AAOS), these ... areas of musculoskeletal health: Bio-enhanced ...
... paint containing dangerous,concentrations of lead is being sold in ... refusing to remove the paint from store shelves. , ... the lead content of paint in,Cameroon to protect public ... (OK International) and co-author of a new,research study about ...
... Rochelle, NY, Mar 19, 2013Chronic fatigue, a persistent lack ... at least three times more prevalent among adult survivors ... or adolescence than in the general adult population, according ... Young Adult Oncology (JAYAO), ( http://www.liebertpub.com/JAYAO ) a ...
Cached Biology News:AAOS awards recognize innovative orthopaedic research 2AAOS awards recognize innovative orthopaedic research 3AAOS awards recognize innovative orthopaedic research 4US company identified as manufacture of lead paint in Africa 2Are survivors of childhood leukemia and lymphoma at greater risk of chronic fatigue as adults? 2
(Date:12/19/2014)... 19, 2014 The empty capsules ... rising ageing population and technological innovations in the ... industries are catalysing the growth of the empty ... http://www.marketsandmarkets.com/Market-Reports/empty-capsules-market-218018190.html , Scope of Report , The ... as new entrants/smaller firms to gauge the pulse ...
(Date:12/19/2014)... 2014   ISN has released its third ... publication series. With data aggregated from over ... 2013 within its online contractor management platform, ISNetworld, this ... indicator (KPI) statistics. The ... publication is available in two industry specific volumes: ...
(Date:12/17/2014)... “Never say, ‘I cannot do ... Department of Physics, advises young women pursuing careers ... SPIE Women in Optics 18-month planner ... ask questions.” , In the annual planner, women ... ranging from university professor and laboratory researcher to ...
(Date:12/17/2014)... This report is a professional ... For an overview analysis, the report introduces quartz ... structure, industry overview, policy analysis, and news analysis, ... has witnessed rapid development with key manufacturers increasing ... report mentions quartz tubing upstream raw materials and ...
Breaking Biology Technology:Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 3Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 4ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 32020 Quartz Tubing Market: Global Development & Forecasts Analysis Now at DeepResearchReports.com 2
... 12 The Board of,Directors of Baxter International Inc. ... $0.2175 per share of Baxter common stock., This ... was,increased earlier this year by 30 percent. This quarterly ... record as of March 10, 2008., Baxter International ...
... Feb. 12 /PRNewswire-FirstCall/ . Maxygen, Inc.,(Nasdaq: MAXY ... of,improved protein drugs, today reported financial results for ... At December 31, 2007, cash, cash,equivalents and marketable ... December 31, 2006., "After a productive year ...
... Calif., Feb. 12 Peregrine,Pharmaceuticals, Inc. (Nasdaq: ... therapies for the treatment of cancer and,hepatitis C ... has,begun in its clinical trial designed to evaluate ... chemotherapy in patients with advanced,breast cancer. The primary ...
Cached Biology Technology:Maxygen Reports Fourth Quarter and Year End 2007 Financial Results 2Maxygen Reports Fourth Quarter and Year End 2007 Financial Results 3Maxygen Reports Fourth Quarter and Year End 2007 Financial Results 4Maxygen Reports Fourth Quarter and Year End 2007 Financial Results 5Maxygen Reports Fourth Quarter and Year End 2007 Financial Results 6Peregrine Pharmaceuticals Doses First Patient in Phase II Clinical Trial of Bavituximab in Patients With Advanced Breast Cancer 2Peregrine Pharmaceuticals Doses First Patient in Phase II Clinical Trial of Bavituximab in Patients With Advanced Breast Cancer 3Peregrine Pharmaceuticals Doses First Patient in Phase II Clinical Trial of Bavituximab in Patients With Advanced Breast Cancer 4
... DNA Engine Dyad thermal cycler is ... (PCR). The chassis accommodates a variety ... assemblies), which hold different types and ... graphical programming with point-and-click navigation. Peltier ...
MiniCycler thermal cycler with Hot Bonnet heated lid, holds 25x0.2ml tubes...
For demonstration of Helicobacter pylori...
... FLISP Assay with SR-101 Labeled Substrates ... • Accurately measure serine protease activation ... • B-Bridge's FLISP Kits utilize cell-permeable, ... (FLISPs) to measure chymotrypsin-like activity in ...
Biology Products: