Navigation Links
Taking sharper aim at stomach ulcer bacteria
Date:9/30/2009

Scientists are reporting discovery of a much sought after crack in the armor of a common microbe that infects the stomachs of one-sixth of the world's population, causing stomach ulcers and other diseases. They identified a group of substances that block a key chemical pathway that the bacteria need for survival. Their study, which could lead to new, more effective antibiotics to fight these hard-to-treat microbes, is scheduled for the October 16 issue of ACS Chemical Biology, a monthly journal.

Javier Sancho and colleagues note in the new study that Helicobacter pylori ( H. pylori ) bacteria infect the stomach lining and can cause gastritis and ulcers. Treatment with broad-spectrum antibiotics can cure H. pylori infections. However, an estimated one billion people remain infected worldwide because of the cost of existing antibiotics and the emergence of antibiotic resistant strains of the bacteria, the researchers say.

The scientists knew from past research that blocking flavodoxin, a key protein that H. pylori needs for survival, could be the key to developing narrow-spectrum antibiotics that specifically target H. pylori. Sancho's team screened 10,000 chemicals for their ability to block flavodoxin and identified four that showed promise. They then showed that three of the four substances killed H. pylori in cell cultures and did not have any apparent toxic effects in lab animals. "These new inhibitors constitute promising candidates to develop new specific antibiotics against H. pylori," the study states.


'/>"/>

Contact: Michael Woods
m_woods@acs.org
202-872-6293
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Research shows that invisible hand guides evolution of cooperative turn-taking
2. Taking the pulse of our planet
3. Taking the next step toward advanced artificial limbs
4. Taking a cue from breath fresheners, researcher develops new method for taste testing
5. Harmful algae taking advantage of global warming
6. Taking the fight against cancer to heart
7. Aging gracefully requires taking out the trash
8. Sharper image: UH optometrist establishes sports vision clinic
9. Astronomy technology brings nanoparticle probes into sharper focus
10. Tummy troubles -- gastrin key in bacterial-induced stomach cancer
11. Fatty foods -- not empty stomach -- fire up hunger hormone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... and ITHACA, N.Y. , ... and Cornell University, a leader in dairy research, today ... bioinformatics designed to help reduce the chances that the ... the onset of this dairy project, Cornell University has ... for Sequencing the Food Supply Chain, a food safety ...
(Date:5/16/2017)... 16, 2017  Veratad Technologies, LLC ( www.veratad.com ), ... and identity verification solutions, announced today they will participate ... May 15 thru May 17, 2017, in ... Trade Center. Identity impacts the lives ... today,s quickly evolving digital world, defining identity is critical ...
(Date:4/24/2017)... 2017 Janice Kephart , former ... Strategy Partners, LLP (IdSP) , today issues the ... Trump,s March 6, 2017 Executive Order: Protecting ... can be instilled with greater confidence, enabling the ... refugee applications are suspended by until at least ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... ... July 20, 2017 , ... Litmus Health ... announced its full advisory board. The board comprises leaders spanning business, technology, academia, ... PhD, former VP of Engineering, to Chief Technology Officer. Crooks will lead strategy ...
(Date:7/20/2017)... and PLYMOUTH, Minn., July 20, 2017   KCNQ2 ... personalized genetic evaluations company, today announced that they ... investigating a genetic mutation implicated in KCNQ2 epileptic ... partnership for a second case involving an additional ... KCNQ2 Cure Alliance and Pairnomix entered into a ...
(Date:7/18/2017)... ... July 18, 2017 , ... ... and biotherapeutics development, announces the launch of a new NTA biosensor chip for ... researchers to study the kinetics of polyhistidine-tagged (His-tagged) molecules quickly and reliably. ...
(Date:7/18/2017)... , ... July 18, 2017 , ... ... the United States Patent and Trademark Office for its Patent Applications 14/858,857 and ... Office’s allowances of these patent applications further expand the protection of G-CON’s R&D ...
Breaking Biology Technology: