Navigation Links
Takeda and UCL to work together to tackle muscle disorders
Date:3/9/2014

Japanese pharmaceutical company Takeda will work with University College London (UCL) to drive research into tackling muscle disorders, in particular muscular dystrophy.

The research which is being conducted by the research group of Dr Francesco Saverio Tedesco is being supported through funding of $250,000 from the company's New Frontier Sciences group. Takeda's NFS aims to support innovative, cutting-edge research which could eventually lead to drug discovery and development.

Dr Tedesco's team will focus on the study of muscular regeneration and the potential for stem cell therapies to treat muscular dystrophy, in particular induced pluripotent (iPS) stem cells.

The team is also investigating the potential for treating muscular dystrophy through developing novel gene and cell therapy strategies using artificial human chromosomes and novel biomaterials.

Using this approach, Dr Tedesco hopes to overcome a number of current limitations to developing effective treatments for muscular dystrophies. It is hoped that through the use of these modified stem cells, large quantities of progenitor cells could be produced to be transplanted into a patient's muscle following genetic correction or to be used for drug development platforms.

Importantly, the team will attempt to produce these cells which can be applied more easily in a clinical context, in order to reduce the hurdles that might limit their possible future use in clinical studies.

Through previous work using a mouse model of Duchenne muscular dystrophy, the team has already demonstrated the potential of pre-clinical gene replacement therapy using an artificial human chromosome.

Moreover, in a separate study, Dr Tedesco and his team also demonstrated the potential of genetically corrected iPS cells which had been transplanted into another mouse model of a genetic muscle disorder (limb-girdle muscular dystrophy 2D).

Commenting on the new funding for his research, Dr Tedesco, from the UCL Department of Cell and Developmental Biology, said:

"This funding from Takeda comes at a crucial time for building on our research to develop new and innovative approaches to developing potentially life-changing treatments for muscular dystrophies.

"With Takeda's backing, my team and I will be building on the processes we've already shown to be promising and which could pave the way for the development of novel strategies for both cell therapies and drug discovery in muscle disorders."

Gordon Wong, D.Phil., Head of New Frontier Science at Takeda, added:

"We are delighted to support Dr Tedesco and his team because their ground breaking work has the potential for significant patient benefit."

"That several different strands of their research have already borne fruit was strong evidence for us of the translational potential of Dr Tedesco's research for muscular dystrophies."


'/>"/>

Contact: Henry Rummins
h.rummins@ucl.ac.uk
44-207-679-9063
University College London
Source:Eurekalert

Related biology news :

1. Scripps Research and Takeda Pharmaceuticals announce expanded research collaboration
2. Elsevier and Energy Institute work together to publish Journal of the Energy Institute
3. Stanford researchers discover how brain regions work together, or alone
4. New organization brings together top researchers to sequence the genomes of invertebrates
5. New organization brings together top researchers to sequence genomes of invertebrates
6. First International Bioenergy Conference brings together world-leading experts
7. Bonding together to fight HIV
8. Fraunhofer and Continental come together when the dandelion rubber meets the road
9. PD map: Putting together the pieces of the Parkinsons puzzle
10. Institut Pasteur Korea -- DNDi come together for the fight against neglected diseases
11. Telecoupling pulls pieces of sustainability puzzle together
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... N.Y. and ITHACA, N.Y. ... ) and Cornell University, a leader in dairy research, ... with bioinformatics designed to help reduce the chances that ... With the onset of this dairy project, Cornell University ... Consortium for Sequencing the Food Supply Chain, a food ...
(Date:5/23/2017)...  Hunova, the first robotic gym for the rehabilitation and functional motor ... Genoa, Italy . The first 30 robots will be ... USA . The technology was developed and patented at the ... spin-off Movendo Technology thanks to a 10 million euro investment from entrepreneur ... ...
(Date:5/16/2017)... DALLAS , May 16, 2017   ... for health organizations, and MD EMR Systems ... certified development partner for GE, have established a ... Patient Portal product and the GE Centricity™ products, ... Centricity EMR. These new integrations ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for ... June 2018 in San Francisco, CA. The Summit brings together current and former FDA ... board directors and government officials from around the world to address key issues in ...
(Date:10/11/2017)... a leading provider of patient support solutions, has announced the ... which will launch this week. The VMS CNEs will address ... enhance the patient care experience by delivering peer-to-peer education programs ... to help women who have been diagnosed and are being ... ...
(Date:10/11/2017)... ... ... Disappearing forests and increased emissions are the main causes of the evolving ... those living in larger cities are affected by air pollution related diseases. , That ... countries globally - decided to take action. , “I knew I had to take ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh ... orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of ... SBT-100 is able to cross the cell membrane and bind intracellular STAT3 and ...
Breaking Biology Technology: