Navigation Links
Takeda and UCL to work together to tackle muscle disorders
Date:3/9/2014

Japanese pharmaceutical company Takeda will work with University College London (UCL) to drive research into tackling muscle disorders, in particular muscular dystrophy.

The research which is being conducted by the research group of Dr Francesco Saverio Tedesco is being supported through funding of $250,000 from the company's New Frontier Sciences group. Takeda's NFS aims to support innovative, cutting-edge research which could eventually lead to drug discovery and development.

Dr Tedesco's team will focus on the study of muscular regeneration and the potential for stem cell therapies to treat muscular dystrophy, in particular induced pluripotent (iPS) stem cells.

The team is also investigating the potential for treating muscular dystrophy through developing novel gene and cell therapy strategies using artificial human chromosomes and novel biomaterials.

Using this approach, Dr Tedesco hopes to overcome a number of current limitations to developing effective treatments for muscular dystrophies. It is hoped that through the use of these modified stem cells, large quantities of progenitor cells could be produced to be transplanted into a patient's muscle following genetic correction or to be used for drug development platforms.

Importantly, the team will attempt to produce these cells which can be applied more easily in a clinical context, in order to reduce the hurdles that might limit their possible future use in clinical studies.

Through previous work using a mouse model of Duchenne muscular dystrophy, the team has already demonstrated the potential of pre-clinical gene replacement therapy using an artificial human chromosome.

Moreover, in a separate study, Dr Tedesco and his team also demonstrated the potential of genetically corrected iPS cells which had been transplanted into another mouse model of a genetic muscle disorder (limb-girdle muscular dystrophy 2D).

Commenting on the new funding for his research, Dr Tedesco, from the UCL Department of Cell and Developmental Biology, said:

"This funding from Takeda comes at a crucial time for building on our research to develop new and innovative approaches to developing potentially life-changing treatments for muscular dystrophies.

"With Takeda's backing, my team and I will be building on the processes we've already shown to be promising and which could pave the way for the development of novel strategies for both cell therapies and drug discovery in muscle disorders."

Gordon Wong, D.Phil., Head of New Frontier Science at Takeda, added:

"We are delighted to support Dr Tedesco and his team because their ground breaking work has the potential for significant patient benefit."

"That several different strands of their research have already borne fruit was strong evidence for us of the translational potential of Dr Tedesco's research for muscular dystrophies."


'/>"/>

Contact: Henry Rummins
h.rummins@ucl.ac.uk
44-207-679-9063
University College London
Source:Eurekalert

Related biology news :

1. Scripps Research and Takeda Pharmaceuticals announce expanded research collaboration
2. Elsevier and Energy Institute work together to publish Journal of the Energy Institute
3. Stanford researchers discover how brain regions work together, or alone
4. New organization brings together top researchers to sequence the genomes of invertebrates
5. New organization brings together top researchers to sequence genomes of invertebrates
6. First International Bioenergy Conference brings together world-leading experts
7. Bonding together to fight HIV
8. Fraunhofer and Continental come together when the dandelion rubber meets the road
9. PD map: Putting together the pieces of the Parkinsons puzzle
10. Institut Pasteur Korea -- DNDi come together for the fight against neglected diseases
11. Telecoupling pulls pieces of sustainability puzzle together
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... India , March 23, 2017 The report "Gesture ... Touchless Biometric), Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, ... at a CAGR of 29.63% between 2017 and 2022. ... ... ...
(Date:3/22/2017)... Vigilant Solutions , a vehicle location ... announced today the appointment of retired FBI special agent ... business development. Mr. Sheridan brings more than ... focus on the aviation transportation sector, to his new ... Sheridan served as the Aviation Liaison Agent Coordinator (ALAC) ...
(Date:3/13/2017)... March 13, 2017 Future of security: Biometric Face Matching ... ... DERMALOGs Face Matching enables to match face pictures against each ... to identify individuals. (PRNewsFoto/Dermalog Identification Systems) ... DERMALOG,s "Face Matching" is the fastest software for biometric Face Matching on ...
Breaking Biology News(10 mins):
(Date:4/21/2017)... ... ... Having worked on the design of the innovative Triton™ lab bench ... design architects from around the country at the Lab Design Conference 2017 in Raleigh, ... Casey will be at the show, where they will highlight the unique elements of ...
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... ... accelerator dedicated to nourishing a range of emerging technology-based businesses, recently earned a ... Metropolitan Court location. , Founded in 2004, FITCI is Frederick’s first incubator. ...
(Date:4/20/2017)... ... 2017 , ... Husson University will be celebrating students and ... knowledge during its Eighth Annual Research and Scholarship Day on Thursday, ... the event, undergraduates, graduate students, and faculty members from all of the university’s ...
(Date:4/20/2017)... ... April 20, 2017 , ... ... unique intellectual property (IP) sharing and commercialization model. , The Center for Advancing ... main component of this effort is bringing the IP to the attention of ...
Breaking Biology Technology: