Navigation Links
Tags? We're it. NIST opens new 'biolabeling' research facility
Date:11/23/2011

With the recent opening of its new Biomolecular Labeling Laboratory, the National Institute of Standards and Technology (NIST) has become one of a small handful of facilities in the world that specializes in tagging large molecules with different isotopes to make them easier to analyze. The new NIST lab is available to outside researchers, particularly those in biomedical fields who also want to take advantage of the NIST Center for Neutron Research (NCNR)'s analysis tools.

The "BL-squared" lab, a collaboration between NIST and the University of Maryland, should interest drug manufacturers, who need details about the structure and behavior of protein molecules that could become new medicines. Scientists prefer to make a novel molecule stand out from its background so they can spot it more easily with certain lab techniques, such as nuclear magnetic resonance (NMR), small angle neutron scattering (SANS) and mass spectrometry.

Isotope tagging is a particularly effective way to enhance a molecule's visibility. Some of its common atoms -- hydrogen, carbon and nitrogen, for example -- are exchanged for heavier versions of themselves. These rare stable isotopes -- deuterium, carbon-13 and nitrogen-15 -- are not radioactive, but their different atomic mass makes the "labeled" molecule more visible during SANS, NMR or other types of measurements.

While biolabeling can be done on an ad hoc basis in any lab, NIST's Zvi Kelman says that the new lab will bring greater efficiency to the process.

"Now NIST will have the ability to produce and label biomolecules with different patterns and levels of isotopes," says Kelman, who recently moved from the University of Maryland to NIST's Biochemical Science Division. "Our facility is an open collaboration, so once we learn something about marking one biomolecule, we can then turn around and apply that knowledge to other users' projects."

Up to five clients, or "users," will have room to work simultaneously in the lab, while its close proximity to the NCNR means that users can take advantage of the NCNR's many neutron-based scanning methods as well. The lab will be able to accommodate about 50 to 60 users per year, according to Kelman, and it will be unusual in that there will be no requirement that users analyze their newly labeled molecules at NIST.


'/>"/>
Contact: Chad Boutin
chad.boutin@nist.gov
301-975-4261
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Related biology news :

1. Study of polar dinosaur migration questions whether dinosaurs were truly the first great migrators
2. Solar-powered sea-slugs live like plants, prof says
3. CT scans reveal that dinosaurs were airheads
4. Clinical trial shows quadriplegics can operate powered wheelchair with tongue drive system
5. The first men and women from the Canary Islands were Berbers
6. Solar-powered irrigation significantly improves diet and income in rural sub-Saharan Africa
7. Ethanol-powered vehicles generate more ozone than gas-powered ones
8. Were short warm periods typical for transitions between interglacial and glacial epochs?
9. Brain tumor growth linked to lowered expression of hundreds of immune function genes
10. Oil from spill could have powered 38,000 cars (and more) for a year, UD researcher says
11. Montana State researchers say Triceratops, Torsaurus were same dinosaur at different stages
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tags? We're it. NIST opens new 'biolabeling' research facility
(Date:3/30/2017)... 30, 2017 The research team of The ... (3D) fingerprint identification by adopting ground breaking 3D fingerprint minutiae recovery ... of speed and accuracy for use in identification, crime investigation, immigration ... ... A research team ...
(Date:3/27/2017)... , March 27, 2017  Catholic Health Services ... Management Systems Society (HIMSS) Analytics for achieving Stage ... Model sm . In addition, CHS previously earned ... hospitals using an electronic medical record (EMR). ... high level of EMR usage in an outpatient ...
(Date:3/23/2017)... Research and Markets has announced the addition of the "Global ... 2025" report to their offering. ... The Global Vehicle Anti-Theft System Market is ... next decade to reach approximately $14.21 billion by 2025. ... all the given segments on global as well as regional levels ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... ... Building on the success of the inaugural RAADfest last year, RAADfest 2017 ... in radical life extension. RAADfest combines cutting edge science presented for a lay audience, ... making it the largest most comprehensive and inclusive super longevity event in the world. ...
(Date:6/22/2017)... , ... June 22, 2017 , ... ... results to clients throughout the biopharma and life sciences industries, continue to be ... is seeing. Tunnell’s Kip Wolf will be speaking on “The State of Information ...
(Date:6/20/2017)... Hill, CT (PRWEB) , ... June 20, 2017 ... ... support, today announced that the CTNext board of directors has formed a Higher ... by a working group composed of institution presidents and other high-ranking representatives from ...
(Date:6/20/2017)... ... June 20, 2017 , ... ... a well-versed leader with extensive assay development and biomarker expertise, as VP of ... a Boston CRO specializing in bio-analytical assay development and sample testing services. The ...
Breaking Biology Technology: