Navigation Links
Tags? We're it. NIST opens new 'biolabeling' research facility
Date:11/23/2011

With the recent opening of its new Biomolecular Labeling Laboratory, the National Institute of Standards and Technology (NIST) has become one of a small handful of facilities in the world that specializes in tagging large molecules with different isotopes to make them easier to analyze. The new NIST lab is available to outside researchers, particularly those in biomedical fields who also want to take advantage of the NIST Center for Neutron Research (NCNR)'s analysis tools.

The "BL-squared" lab, a collaboration between NIST and the University of Maryland, should interest drug manufacturers, who need details about the structure and behavior of protein molecules that could become new medicines. Scientists prefer to make a novel molecule stand out from its background so they can spot it more easily with certain lab techniques, such as nuclear magnetic resonance (NMR), small angle neutron scattering (SANS) and mass spectrometry.

Isotope tagging is a particularly effective way to enhance a molecule's visibility. Some of its common atoms -- hydrogen, carbon and nitrogen, for example -- are exchanged for heavier versions of themselves. These rare stable isotopes -- deuterium, carbon-13 and nitrogen-15 -- are not radioactive, but their different atomic mass makes the "labeled" molecule more visible during SANS, NMR or other types of measurements.

While biolabeling can be done on an ad hoc basis in any lab, NIST's Zvi Kelman says that the new lab will bring greater efficiency to the process.

"Now NIST will have the ability to produce and label biomolecules with different patterns and levels of isotopes," says Kelman, who recently moved from the University of Maryland to NIST's Biochemical Science Division. "Our facility is an open collaboration, so once we learn something about marking one biomolecule, we can then turn around and apply that knowledge to other users' projects."

Up to five clients, or "users," will have room to work simultaneously in the lab, while its close proximity to the NCNR means that users can take advantage of the NCNR's many neutron-based scanning methods as well. The lab will be able to accommodate about 50 to 60 users per year, according to Kelman, and it will be unusual in that there will be no requirement that users analyze their newly labeled molecules at NIST.


'/>"/>
Contact: Chad Boutin
chad.boutin@nist.gov
301-975-4261
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Related biology news :

1. Study of polar dinosaur migration questions whether dinosaurs were truly the first great migrators
2. Solar-powered sea-slugs live like plants, prof says
3. CT scans reveal that dinosaurs were airheads
4. Clinical trial shows quadriplegics can operate powered wheelchair with tongue drive system
5. The first men and women from the Canary Islands were Berbers
6. Solar-powered irrigation significantly improves diet and income in rural sub-Saharan Africa
7. Ethanol-powered vehicles generate more ozone than gas-powered ones
8. Were short warm periods typical for transitions between interglacial and glacial epochs?
9. Brain tumor growth linked to lowered expression of hundreds of immune function genes
10. Oil from spill could have powered 38,000 cars (and more) for a year, UD researcher says
11. Montana State researchers say Triceratops, Torsaurus were same dinosaur at different stages
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tags? We're it. NIST opens new 'biolabeling' research facility
(Date:5/12/2016)... -- WearablesResearch.com , a brand of Troubadour Research ... the Q1 wave of its quarterly wearables survey. A ... to a program where they would receive discounts for ... "We were surprised to see that so ... , CEO of Troubadour Research, "primarily because there are ...
(Date:4/28/2016)... First quarter 2016:   , ... the first quarter of 2015 The gross margin was ... 18.8) and the operating margin was 40% (-13) Earnings ... flow from operations was SEK 249.9 M (21.2) , ... SEK 7,000-8,500 M. The operating margin for 2016 is ...
(Date:4/15/2016)... , April 15, 2016  A new ... make more accurate underwriting decisions in a fraction ... timely, competitively priced and high-value life insurance policies ... screenings. With Force Diagnostics, rapid testing ... lifestyle data readings (blood pressure, weight, pulse, BMI, ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... /PRNewswire/ - FACIT has announced the creation of ... company, Propellon Therapeutics Inc. ("Propellon" or "the Company"), ... portfolio of first-in-class WDR5 inhibitors for the treatment ... represent an exciting class of therapies, possessing the ... cancer patients. Substantial advances have been achieved with ...
(Date:6/23/2016)... 23, 2016  The Prostate Cancer Foundation (PCF) is pleased to ... faster cures for prostate cancer. Members of the Class of 2016 were selected ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... , ... STACS DNA Inc., the sample tracking software company, today announced that ... joined STACS DNA as a Field Application Specialist. , “I am thrilled that ... of STACS DNA. “In further expanding our capacity as a scientific integrator, Hays brings ...
(Date:6/23/2016)... June 23, 2016 ... 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 Published recently ... peer-reviewed journal from touchONCOLOGY, Andrew D Zelenetz ... of cancer care is placing an increasing burden ... expensive biologic therapies. With the patents on many ...
Breaking Biology Technology: