Navigation Links
Tags? We're it. NIST opens new 'biolabeling' research facility
Date:11/23/2011

With the recent opening of its new Biomolecular Labeling Laboratory, the National Institute of Standards and Technology (NIST) has become one of a small handful of facilities in the world that specializes in tagging large molecules with different isotopes to make them easier to analyze. The new NIST lab is available to outside researchers, particularly those in biomedical fields who also want to take advantage of the NIST Center for Neutron Research (NCNR)'s analysis tools.

The "BL-squared" lab, a collaboration between NIST and the University of Maryland, should interest drug manufacturers, who need details about the structure and behavior of protein molecules that could become new medicines. Scientists prefer to make a novel molecule stand out from its background so they can spot it more easily with certain lab techniques, such as nuclear magnetic resonance (NMR), small angle neutron scattering (SANS) and mass spectrometry.

Isotope tagging is a particularly effective way to enhance a molecule's visibility. Some of its common atoms -- hydrogen, carbon and nitrogen, for example -- are exchanged for heavier versions of themselves. These rare stable isotopes -- deuterium, carbon-13 and nitrogen-15 -- are not radioactive, but their different atomic mass makes the "labeled" molecule more visible during SANS, NMR or other types of measurements.

While biolabeling can be done on an ad hoc basis in any lab, NIST's Zvi Kelman says that the new lab will bring greater efficiency to the process.

"Now NIST will have the ability to produce and label biomolecules with different patterns and levels of isotopes," says Kelman, who recently moved from the University of Maryland to NIST's Biochemical Science Division. "Our facility is an open collaboration, so once we learn something about marking one biomolecule, we can then turn around and apply that knowledge to other users' projects."

Up to five clients, or "users," will have room to work simultaneously in the lab, while its close proximity to the NCNR means that users can take advantage of the NCNR's many neutron-based scanning methods as well. The lab will be able to accommodate about 50 to 60 users per year, according to Kelman, and it will be unusual in that there will be no requirement that users analyze their newly labeled molecules at NIST.


'/>"/>
Contact: Chad Boutin
chad.boutin@nist.gov
301-975-4261
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Related biology news :

1. Study of polar dinosaur migration questions whether dinosaurs were truly the first great migrators
2. Solar-powered sea-slugs live like plants, prof says
3. CT scans reveal that dinosaurs were airheads
4. Clinical trial shows quadriplegics can operate powered wheelchair with tongue drive system
5. The first men and women from the Canary Islands were Berbers
6. Solar-powered irrigation significantly improves diet and income in rural sub-Saharan Africa
7. Ethanol-powered vehicles generate more ozone than gas-powered ones
8. Were short warm periods typical for transitions between interglacial and glacial epochs?
9. Brain tumor growth linked to lowered expression of hundreds of immune function genes
10. Oil from spill could have powered 38,000 cars (and more) for a year, UD researcher says
11. Montana State researchers say Triceratops, Torsaurus were same dinosaur at different stages
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tags? We're it. NIST opens new 'biolabeling' research facility
(Date:4/4/2017)...   EyeLock LLC , a leader of iris-based ... Patent and Trademark Office (USPTO) has issued U.S. Patent ... an iris image with a face image acquired in ... 45 th issued patent. "The ... the multi-modal biometric capabilities that have recently come to ...
(Date:3/30/2017)... NEW YORK , March 30, 2017 ... by type (physiological and behavioral), by technology (fingerprint, AFIS, ... recognition, voice recognition, and others), by end use industry ... travel and immigration, financial and banking, and others), and ... Europe , Asia Pacific ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed Anwar ... the prestigious international IAIR Award for the most innovative high security ePassport ... ... Maldives Immigration Controller General, Mr. ... on the right) have received the IAIR award for the "Most innovative ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... Oct. 11, 2017  VMS BioMarketing, a leading provider of ... oncology Clinical Nurse Educator (CNE) network, which will launch this ... communication among health care professionals to enhance the patient care ... staff, and other health care professionals to help women who ... ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions ... over 5.5 million people each year. Especially those living in larger cities are affected ... based in one of the most pollution-affected countries globally - decided to take action. ...
(Date:10/11/2017)... ... 11, 2017 , ... Singh Biotechnology today announced that the ... its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B VHH13 single ... the cell membrane and bind intracellular STAT3 and inhibit its function. Dysregulation of ...
(Date:10/10/2017)... Los Angeles, CA (PRWEB) , ... ... ... Pharmaceuticals, Inc., a development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) ... all uses of targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed ...
Breaking Biology Technology: