Navigation Links
Tagging tumors with gold: Scientists use gold nanorods to flag brain tumors
Date:10/12/2011

WASHINGTON, Oct. 12"It's not brain surgery" is a phrase often uttered to dismiss a job's difficulty, but when the task actually is removing a brain tumor, even the slightest mistake could have serious health consequences. To help surgeons in such high-pressure situations, researchers from Prof. Adam Wax's team at Duke University's Fitzpatrick Institute for Photonics and Biomedical Engineering Department have proposed a way to harness the unique optical properties of gold nanoparticles to clearly distinguish a brain tumor from the healthy, and vital, tissue that surrounds it. The team will present their findings at the Optical Society's (OSA) Annual Meeting, Frontiers in Optics (FiO) 2011 (http://www.frontiersinoptics.com/), taking place in San Jose, Calif. next week.

Current techniques for outlining brain tumors vary, but all have limitations, such as the inability to perform real-time imaging without big, expensive equipment, or the toxicity and limited lifespan of certain labeling agents. Gold nanoparticleswhich are so small that 500 of them end-to-end could fit across a human hairmight provide a better way to flag tumorous tissue, since they are non-toxic and relatively inexpensive to manufacture.

The Duke researchers synthesized gold, rod-shaped nanoparticles with varying length-to-width ratios. The different-sized particles displayed different optical properties, so by controlling the nanorods' growth the team could "tune" the particles to scatter a specific frequency of light. The researchers next joined the tuned particles to antibodies that bind to growth factor receptor proteins found in unusually high concentrations on the outside of cancer cells. When the antibodies latched on to cancer cells, the gold nanoparticles marked their presence.

The team tested the method by bathing slices of tumor-containing mouse brain in a solution of gold nanoparticles merged with antibodies. Shining the tuned frequency of light on the sample revealed bright points where the tumors lurked. The tunability of the gold nanoparticles is important, says team member Kevin Seekell, because it allows researchers to choose from a window of light frequencies that are not readily absorbed by biological tissue. It might also allow researchers to attach differently tuned nanoparticles to different antibodies, providing a way to diagnose different types of tumors based the specific surface proteins the cancer cells display. Future work by the team will also focus on developing a surgical probe that can image gold nanoparticles in a living brain, Seekell says.


'/>"/>

Contact: Angela Stark
astark@osa.org
202-416-1443
Optical Society of America
Source:Eurekalert  

Related biology news :

1. Fighting cancers by tagging their triggers
2. New tagging technique enhances view of living cells
3. Sensor chip for monitoring tumors
4. Researchers demonstrate green tea is effective in treating genetic disorder and types of tumors
5. Stem cells central to pathogenesis of mature lymphoid tumors
6. Penn vet researchers show lymphoma drug shrinks dog tumors, could lead to human treatment
7. Mushroom compound suppresses prostate tumors
8. MIT: Removable cloak for nanoparticles helps them target tumors
9. FDA approves the NovoTTF-100A system for the treatment of patients with recurrent glioblastoma multiforme (GBM) brain tumors
10. PMH researchers create an organic nanoparticle that uses sound and heat to find and treat tumors
11. With new method, CSHL team is able to infer how tumors evolve and spread
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tagging tumors with gold: Scientists use gold nanorods to flag brain tumors
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, ... Infrastructure, Support & Other Service  The latest ... comprehensive analysis of the global Border Security market ... of $17.98 billion in 2016. Now: In ... in software and hardware technologies for advanced video surveillance. ...
(Date:5/24/2016)... facilitates superior patient care by providing unparalleled technology to leaders of the medical imaging ... product recently added to the range of products distributed by Ampronix. Photo ... ... ... News ...
(Date:5/16/2016)... 2016   EyeLock LLC , a market leader ... of an IoT Center of Excellence in ... development of embedded iris biometric applications. EyeLock,s ... and security with unmatched biometric accuracy, making it the ... DNA. EyeLock,s platform uses video technology to deliver a ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... TOKYO , June 24, 2016  Regular discussions on ... to take place between the two entities said Poloz. ... in Ottawa , he pointed to the ... and the federal government. ... Poloz said, "Both institutions have common economic goals, why not ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering ... retention in this eBook by providing practical tips, tools, and strategies for clinical ...
(Date:6/23/2016)... , June 23, 2016 A person commits ... the crime scene to track the criminal down. ... U.S. Food and Drug Administration (FDA) uses DNA evidence to ... Sound far-fetched? It,s not. The FDA has ... to support investigations of foodborne illnesses. Put as simply as ...
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge ... envision new ways to harness living systems and biotechnology, ... Art (MoMA) in New York City ... 130 participating students, showcased projects at MoMA,s Celeste Bartos ... Paola Antonelli , MoMA,s senior curator of architecture and ...
Breaking Biology Technology: