Navigation Links
Tagging tumors with gold: Scientists use gold nanorods to flag brain tumors
Date:10/12/2011

WASHINGTON, Oct. 12"It's not brain surgery" is a phrase often uttered to dismiss a job's difficulty, but when the task actually is removing a brain tumor, even the slightest mistake could have serious health consequences. To help surgeons in such high-pressure situations, researchers from Prof. Adam Wax's team at Duke University's Fitzpatrick Institute for Photonics and Biomedical Engineering Department have proposed a way to harness the unique optical properties of gold nanoparticles to clearly distinguish a brain tumor from the healthy, and vital, tissue that surrounds it. The team will present their findings at the Optical Society's (OSA) Annual Meeting, Frontiers in Optics (FiO) 2011 (http://www.frontiersinoptics.com/), taking place in San Jose, Calif. next week.

Current techniques for outlining brain tumors vary, but all have limitations, such as the inability to perform real-time imaging without big, expensive equipment, or the toxicity and limited lifespan of certain labeling agents. Gold nanoparticleswhich are so small that 500 of them end-to-end could fit across a human hairmight provide a better way to flag tumorous tissue, since they are non-toxic and relatively inexpensive to manufacture.

The Duke researchers synthesized gold, rod-shaped nanoparticles with varying length-to-width ratios. The different-sized particles displayed different optical properties, so by controlling the nanorods' growth the team could "tune" the particles to scatter a specific frequency of light. The researchers next joined the tuned particles to antibodies that bind to growth factor receptor proteins found in unusually high concentrations on the outside of cancer cells. When the antibodies latched on to cancer cells, the gold nanoparticles marked their presence.

The team tested the method by bathing slices of tumor-containing mouse brain in a solution of gold nanoparticles merged with antibodies. Shining the tuned frequency of light on the sample revealed bright points where the tumors lurked. The tunability of the gold nanoparticles is important, says team member Kevin Seekell, because it allows researchers to choose from a window of light frequencies that are not readily absorbed by biological tissue. It might also allow researchers to attach differently tuned nanoparticles to different antibodies, providing a way to diagnose different types of tumors based the specific surface proteins the cancer cells display. Future work by the team will also focus on developing a surgical probe that can image gold nanoparticles in a living brain, Seekell says.


'/>"/>

Contact: Angela Stark
astark@osa.org
202-416-1443
Optical Society of America
Source:Eurekalert  

Related biology news :

1. Fighting cancers by tagging their triggers
2. New tagging technique enhances view of living cells
3. Sensor chip for monitoring tumors
4. Researchers demonstrate green tea is effective in treating genetic disorder and types of tumors
5. Stem cells central to pathogenesis of mature lymphoid tumors
6. Penn vet researchers show lymphoma drug shrinks dog tumors, could lead to human treatment
7. Mushroom compound suppresses prostate tumors
8. MIT: Removable cloak for nanoparticles helps them target tumors
9. FDA approves the NovoTTF-100A system for the treatment of patients with recurrent glioblastoma multiforme (GBM) brain tumors
10. PMH researchers create an organic nanoparticle that uses sound and heat to find and treat tumors
11. With new method, CSHL team is able to infer how tumors evolve and spread
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tagging tumors with gold: Scientists use gold nanorods to flag brain tumors
(Date:2/13/2017)... 13, 2017 Former 9/11 Commission border counsel ... Janice Kephart of Identity Strategy Partners, LLP, ... Trump,s "Executive Order: Protecting the Nation From Foreign ... "As President Trump,s ,Travel Ban, Executive Order ... essentially banned the travel ban, it is important that ...
(Date:2/9/2017)... 9, 2017 The biomass boiler market report ... biomass boiler market globally in terms of revenue (US$ ... The market for biomass boilers has been segmented on ... and country/region. The market based on feedstock type, has ... biogas & energy crops, urban residues, and others. On ...
(Date:2/8/2017)... (NASDAQ: AWRE ), a leading supplier of biometrics ... and year ended December 31, 2016. Revenue ... to $6.9 million in the same quarter last year. Operating ... compared to $2.6 million in the fourth quarter of 2015. ... million, or $0.02 per diluted share, which compares to $1.8 ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... , Mar 23, 2017 Research ... Products: Global Markets" report to their offering. ... The Global ... $466.6 Billion in 2016 at a CAGR of 8.9%, ... energetic and non-energetic bioproducts into seven major product segments: bio-derived ...
(Date:3/23/2017)... MILFORD, Mass. , March 23, 2017 ... leading partner to global in vitro diagnostics ... launch of the industry,s first multiplexed ... inherited disease testing by next-generation sequencing ... materials were developed with input from industry ...
(Date:3/23/2017)... March 23, 2017  BioPharmX Corporation (NYSE MKT: ... the dermatology market, today reported financial results for ... and will provide an update on the company,s ... "We are pleased to report that ... BioPharmX," said President Anja Krammer. "We achieved key ...
(Date:3/23/2017)... Kineta, Inc., a biotechnology company focused ... immuno-oncology, today announced the discovery and characterization of ... activate interferon response factor 3 (IRF3) via RIG-I ... regression in a murine colon carcinoma mouse model.  ... tumor regression to initial drug treatment were resistant ...
Breaking Biology Technology: