Navigation Links
TGen presents lung cancer studies at Amsterdam conference
Date:7/7/2011

VARI joins TGen in JAK2 study

The Van Andel Research Institute (VARI), TGen's affiliate in Grand Rapids, Mich., joined TGen in conducting the JAK2 study.

The JAK2 protein can activate the gene called STAT3, part of a family of genes that provide instructions for making proteins that are part of the essential chemical signaling pathways that control growth and development in cells. STAT3 has been found to be overactive in cases of several types of cancer, including breast, prostate, pancreas, leukemia and lymphoma.

In laboratory tests involving seven NSCLC cell lines, the TGen-VARI study found that STAT3 was activated in some cell lines by JAK2, independent of key oncogenic, or cancer-causing mutations.

"JAK2-STAT3 signaling plays crucial roles in tumor-cell behavior that may not be effectively inhibited by drugs that selectively target these mutations," Dr. Weiss said. "This suggests that there may be a potential role for combination therapy, so you have a better chance of knocking out a NSCLC tumor, or keeping it at bay."

Dr. Jeff MacKeigan, Head of VARI's Laboratory of Systems Biology, said this yearlong study, funded by a TGen-VARI integration grant, should benefit future lung cancer research because of the study's clinically annotated tissue microarray.

"Our human tumor samples may be used for meaningful exploratory research on other key signaling pathways in NSCLC," MacKeigan said.


'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Ben-Gurion University team presents environment movement report to Israels Knesset
2. Louisiana Tech researcher presents on eco-friendly nanotechnology at national conference
3. KIT presents innovations at the 2011 Hannover Messe
4. 23andMe presents top 10 most interesting genetic findings of 2010
5. Colossal fossil: Museums new whale skeleton represents decades of research
6. UC doctoral student presents research at international conference
7. American Society of Agronomy presents 2010 Fellows
8. AMP presents at FDA meeting on regulating diagnostics
9. AAPS presents therapeutic protein drug interactions workshop
10. ASNTR meeting presents Sanberg Awards to Prof. Lin & Prof. Dunnett
11. Latino Theater Company Presents Dementia Starting April 29
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Dec. 18, 2014   LaunchKey , the first ... post-password and Internet of Things era, today announced the ... venture round was led by Metamorphic Ventures with participation ... Partners, VegasTechFund, and others.  LaunchKey has raised $4 million ... expand its team and bring LaunchKey to market in ...
(Date:12/17/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ) ... Chemical Sensor Market 2015-2019" report to their ... One major trend upcoming in this ... in biomedical applications. Chemical sensors help in recording ... during surgical procedures. The Global Chemical Sensor market ...
(Date:12/11/2014)... 10, 2014  That blood pressure plays a role in ... – the medical term for high blood pressure – was ... the inflatable cuff that,s used in measuring blood pressure was ... nothing new about hypertension, its triggers and its effects. In ... condition and the best ways to treat it. ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... essential question confronting neuroscientists and computer vision researchers alike is ... Introspectively, we know that the human brain solves this ... something to know what it is. But teaching a ... In research published this fall in the Public Library of ...
... Hay fever (runny nose, sneezing, itchy eyes) is caused by ... These tiny grains bring misery to sufferers through spring and ... weather reports to help sufferers prepare. However new research published ... Allergy shows that, regardless of medication and other allergies, ...
... Mediterranean diet with large amounts of vegetables and fish gives ... studies to be published by the Sahlgrenska Academy at the ... shown that a Mediterranean diet, based on a high consumption ... products such as meat and milk, leads to better health., ...
Cached Biology News:Do you see what I see? 2Do you see what I see? 3Get ready for spring - hay fever worse in spring than summer 2
(Date:12/22/2014)... , Dec. 22, 2014   Synthetic ... developer of pathogen-specific therapies for serious infections ... the microbiome, today announced positive topline safety ... clinical trial of SYN-004, the Company,s investigational ... Clostridium difficile (C. difficile) infection, ...
(Date:12/22/2014)... VIEJO, Calif. , Dec. 22, 2014  ( ... that CoPatient, an online medical bill review and advocacy ... offering in the FREE WellCard Savings discount health services ... medical bill that was more than they expected to ... members reduce health care costs, WellCard Savings is pleased ...
(Date:12/19/2014)... and Hershey, PA (PRWEB) December 19, 2014 ... BJCT), a leading developer and manufacturer of needle-free ... into an agreement with Immunomic Therapeutics, Inc. (“ITI”) ... needle-free injection device with its LAMP™ vaccine platform. ... option for an exclusive Worldwide license to the ...
(Date:12/19/2014)... Calif. , Dec. 19, 2014  Roche (SIX: ... of Bina Technologies, Inc. (Bina), a privately held ... , USA. Bina provides a big data ... generation sequencing (NGS) data. Bina,s proprietary on-market Genomic ... and academic researchers to perform fast and scalable ...
Breaking Biology Technology:Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3
... (Nasdaq: KNDL ), a,leading, global full-service clinical ... Chief Financial Officer Karl,"Buzz" Brenkert, III will participate ... The conference will be held at the,Loews Miami ... Kendle,s,presentation is scheduled for Tuesday, March 18 at ...
... March 14 Quest Diagnostics,Incorporated (NYSE: DGX ... and services, announced that it is scheduled to ... Conference on,Wednesday, March 19, 2008, at The Loews ... is scheduled to begin at 9:00 a.m.,Eastern Time., ...
... March 14 Wyeth (NYSE: WYE ),announced today ... Annual,Global Healthcare Conference on Wednesday, March 19, 2008 at ... M. Mahady, Senior Vice,President, Wyeth and President, Wyeth Pharmaceuticals., ... at, http://www.wyeth.com and available for replay following the ...
Cached Biology Technology:Kendle to Present at the Lehman Brothers Eleventh Annual Global Healthcare Conference 2Quest Diagnostics to Speak at Lehman Brothers 11th Annual Global Healthcare Conference 2Wyeth to Present at the Lehman Brothers Eleventh Annual Global Healthcare Conference 2
...
... Cosmid Cloning Kit enables you to prepare, ... unbiased primary cosmid library of genomic DNA ... sublibraries. High efficiency cosmid library construction is ... protocols. First, genomic DNA is randomly sheared ...
Mouse monoclonal antibody raised against a partial recombinant AATK. NCBI Entrez Gene ID = AATK...
... Analyzer is a revolutionary multi-capillary electrophoresis system ... platform. It integrates sample loading, electrophoresis, and ... improving the workflow and increasing the productivity ... Benefits of using HDA system are:, ...
Biology Products: