PHOENIX, Ariz. July 7, 2011 The Translational Genomics Research Institute (TGen) is presenting two key studies, including one today, at the 14th World Conference on Lung Cancer, July 3-7 in Amsterdam.
One study, presented July 4, involved a gene called GLI1, which may limit the effectiveness of the most common combination chemotherapy given to patients with small cell lung cancer (SCLC).
Another study, presented today, July 7, suggests that combination drug therapy may be needed to combat non-small cell lung cancer (NSCLC) the more common type of lung cancer when patients have elevated levels of a protein called JAK2.
Both studies will be presented at the Amsterdam conference, which is sponsored by the International Association for the Study of Lung Cancer (IASLC). The association hosts an international lung cancer meeting every two years. Both studies also will be published in a special supplement of the Journal of Thoracic Oncology.
GLI1 may compromise chemotherapy
In the study involving GLI1, laboratory tests of six SCLC cell lines showed that GLI1 can play an important role in resistance to the drugs cisplatin and etoposide, which given together are the standard first-line chemotherapy for SCLC.
"Resistance to chemotherapeutic drugs is particularly crippling in SCLC," said Dr. Glen Weiss, Co-Unit Head of TGen's Lung Cancer Research Laboratory, who led the research in both studies presented at the conference. "We are optimistic that this GLI1 study will lead to more detailed examinations that will provide a better way of treating patients."
Next steps include using RNA interference tests to validate the role of GLI1 and several related genes along the Hedgehog Signaling Pathway a series of chemical reactions within a cell. The Hedgehog pathway contains genes that lead to GLI1, a known tumor-promoting gene. Weiss' team also plans to conduct tests on actual tumors from SCLC patients.
|Contact: Steve Yozwiak|
The Translational Genomics Research Institute