Navigation Links
TGen-led studies identify genetic links to kidney disease, kidney failure
Date:6/26/2010

PHOENIX, Ariz. June 26, 2010 Researchers at the Translational Genomics Research Institute (TGen) will make two presentations at this week's 70th Scientific Sessions of the American Diabetes Association, June 25-29, in Orlando, Florida.

One presentation describes a DNA study of American Indians in Arizona, in which a TGen-led team discovered a genetic biomarker with a significant association to kidney failure.

The study showed "the strongest evidence" for association with End Stage Renal Disease (ESRD), or kidney failure, in marker rs13315275, and also found evidence of some lesser associations between ESRD and four other markers.

"This study could someday lead to better treatment options for those patients suffering from diabetic kidney disease," said Dr. Johanna DiStefano, Director of TGen's Diabetes, Cardiovascular and Metabolic Diseases Division, and lead author of the study's abstract. "We are conducting ongoing studies to further investigate these markers, and potentially what they might mean for the development of new therapeutics."

All five biomarkers are genetic variants of the gene SUCNR1, which is located in a chromosomal region of the human genome identified as 3q24-q27. This region has been linked to diabetic nephropathy (DM), or diabetic kidney disease, in previous studies.

SUCNR1 is a receptor gene that acts on succinate in the kidneys to mediate the rennin-angiotensin system (RAS), a hormone system that helps control the body's blood pressure and fluid balance. High blood pressure can damage the heart, kidneys and exacerbate the harmful effects of diabetes.

Past studies have shown that diabetes is relatively high among Arizona's Native American communities.

In another TGen study presented Friday, June 25, at the ADA sessions, researchers initiated an investigation into the ways that the PVT1 gene impacts development of diabetic kidney disease.

Previous studies have shown an association between PVT1 and kidney failure in patients with diabetes, both autoimmune (type 1) and that most commonly caused by excessive weight, poor diet and lack of exercise (type 2).

In the new study, researchers found that PVT1 was expressed in mesangial cells, which are specialized cells around blood vessels in the kidneys, at a rate up to five times higher in conditions of high glucose (high blood sugar), compared to normal glucose levels. High blood sugar is a signature symptom of diabetes.

"These findings show that additional study of the role of PVT1 in diabetic kidney disease is well-justified," said Dr. Lucrecia Alvarez, a TGen Post-Doctoral Fellow and the first author of the study's abstract. Dr. Alvarez announced the findings during an oral presentation at the ADA sessions.


'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Related biology news :

1. International TGen-led team finds link between brain protein and Alzheimers disease
2. Claims of sex-related differences in genetic association studies often not properly validated
3. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
4. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
5. Studies: Children obese due to a host of unhealthy pressures
6. Clinical studies show REMICADE reduces incidence of bowel surgeries in ulcerative colitis patients
7. LSU professor studies army-ant-following birds
8. 2 carotid artery stenting studies show results comparable to AHA guidelines
9. NIH grants enable energy studies
10. New studies on schizophrenia, depression, trauma and autism highlight annual meeting
11. Experts from Stevens, Merck, publish joint paper, Biosynthetic Studies of Platensimycin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/1/2016)... Feb. 1, 2016  Today, the first day of ... plans to develop a first of its kind workplace ... IBM Watson. In the first application of ... IBM ), and Welltok will create a new ... with cognitive analytics, delivered on Welltok,s health optimization platform. ...
(Date:1/25/2016)... 25, 2016   Unisys Corporation (NYSE: UIS ) ... Kennedy (JFK) International Airport, New York City , ... imposters attempting to enter the United States ... pilot testing of the system at Dulles last ... at JFK during January 2016. --> pilot testing ...
(Date:1/21/2016)... India , January 21, 2016 ... According to a new market research report "Emotion Detection ... and Others), Software Tools (Facial Expression, Voice Recognition ... Regions - Global forecast to 2020", published by ... is expected to reach USD 22.65 Billion by ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... Feb. 8, 2016 Should antibiotic bone cement ... products to prevent infection after standard total hip or ... at ECRI Institute have been fielding a lot lately. ... Your Bottom Line?" --> "Antibiotic ... --> While there isn,t a ...
(Date:2/8/2016)...  BioElectronics Corporation (OTC Pink: BIEL), the maker ... it is responding to a notice of an ... Exchange Commission posted on the agency website.  ... Board of BioElectronics Corporation and the Edward and ... Fuqua School of Business, Duke University.   ...
(Date:2/8/2016)... has an active R&D program for the development of ... Group has a unique research and development center in ... Bio Control products. Stockton has a ... regulatory guidelines, and is active in more than 35 counties ... Stockton,s flagship product Timorex Gold ® ...
(Date:2/5/2016)... ATCC, the premier global biological materials resource ... and life science researchers that are working to address ... CDC website . --> CDC ... a single-stranded RNA virus of the Flaviviridae family, genus ... Chikungunya Viruses. Zika virus is transmitted to humans primarily ...
Breaking Biology Technology: