Navigation Links
TGen-led studies identify genetic links to kidney disease, kidney failure
Date:6/26/2010

PHOENIX, Ariz. June 26, 2010 Researchers at the Translational Genomics Research Institute (TGen) will make two presentations at this week's 70th Scientific Sessions of the American Diabetes Association, June 25-29, in Orlando, Florida.

One presentation describes a DNA study of American Indians in Arizona, in which a TGen-led team discovered a genetic biomarker with a significant association to kidney failure.

The study showed "the strongest evidence" for association with End Stage Renal Disease (ESRD), or kidney failure, in marker rs13315275, and also found evidence of some lesser associations between ESRD and four other markers.

"This study could someday lead to better treatment options for those patients suffering from diabetic kidney disease," said Dr. Johanna DiStefano, Director of TGen's Diabetes, Cardiovascular and Metabolic Diseases Division, and lead author of the study's abstract. "We are conducting ongoing studies to further investigate these markers, and potentially what they might mean for the development of new therapeutics."

All five biomarkers are genetic variants of the gene SUCNR1, which is located in a chromosomal region of the human genome identified as 3q24-q27. This region has been linked to diabetic nephropathy (DM), or diabetic kidney disease, in previous studies.

SUCNR1 is a receptor gene that acts on succinate in the kidneys to mediate the rennin-angiotensin system (RAS), a hormone system that helps control the body's blood pressure and fluid balance. High blood pressure can damage the heart, kidneys and exacerbate the harmful effects of diabetes.

Past studies have shown that diabetes is relatively high among Arizona's Native American communities.

In another TGen study presented Friday, June 25, at the ADA sessions, researchers initiated an investigation into the ways that the PVT1 gene impacts development of diabetic kidney disease.

Previous studies have shown an association between PVT1 and kidney failure in patients with diabetes, both autoimmune (type 1) and that most commonly caused by excessive weight, poor diet and lack of exercise (type 2).

In the new study, researchers found that PVT1 was expressed in mesangial cells, which are specialized cells around blood vessels in the kidneys, at a rate up to five times higher in conditions of high glucose (high blood sugar), compared to normal glucose levels. High blood sugar is a signature symptom of diabetes.

"These findings show that additional study of the role of PVT1 in diabetic kidney disease is well-justified," said Dr. Lucrecia Alvarez, a TGen Post-Doctoral Fellow and the first author of the study's abstract. Dr. Alvarez announced the findings during an oral presentation at the ADA sessions.


'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Related biology news :

1. International TGen-led team finds link between brain protein and Alzheimers disease
2. Claims of sex-related differences in genetic association studies often not properly validated
3. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
4. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
5. Studies: Children obese due to a host of unhealthy pressures
6. Clinical studies show REMICADE reduces incidence of bowel surgeries in ulcerative colitis patients
7. LSU professor studies army-ant-following birds
8. 2 carotid artery stenting studies show results comparable to AHA guidelines
9. NIH grants enable energy studies
10. New studies on schizophrenia, depression, trauma and autism highlight annual meeting
11. Experts from Stevens, Merck, publish joint paper, Biosynthetic Studies of Platensimycin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2016)... MINNEAPOLIS , May 20, 2016  VoiceIt ... technology partnership with VoicePass. By working ... user experience.  Because VoiceIt and VoicePass take slightly ... two engines increases both security and usability. ... expressed excitement about this new partnership. ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 /PRNewswire/ ... product subsidiary of Infosys (NYSE: INFY ), and ... global partnership that will provide end customers with ... banking and payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ... area for financial services, but it also plays a fundamental ...
(Date:4/15/2016)... , April 15, 2016  A new ... make more accurate underwriting decisions in a fraction ... timely, competitively priced and high-value life insurance policies ... screenings. With Force Diagnostics, rapid testing ... lifestyle data readings (blood pressure, weight, pulse, BMI, ...
Breaking Biology News(10 mins):
(Date:6/24/2016)...  Regular discussions on a range of subjects including policies, ... entities said Poloz. Speaking at a lecture to ... he pointed to the country,s inflation target, which is set ... "In certain areas there needs ... economic goals, why not sit down and address strategy together?" ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... pleased to announce the launch of their brand, UP4™ Probiotics, into Target stores ... 35 years, is proud to add Target to its list of well-respected retailers. ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm ... Mold) microbial test has received AOAC Research Institute approval 061601. , “This is ... last year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. “The ...
(Date:6/23/2016)... ... , ... STACS DNA Inc., the sample tracking software company, today announced that ... joined STACS DNA as a Field Application Specialist. , “I am thrilled that ... of STACS DNA. “In further expanding our capacity as a scientific integrator, Hays brings ...
Breaking Biology Technology: