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TGen leads new National Institutes of Health study of brain tumors
Date:5/3/2012

s and cellular pathways to target. These targets will be referenced against a database of 54 patient tumor models, looking for small molecules that could lead the way to new cancer drugs.

The resulting pre-clinical drug-treatment models will be tested and validated by Sanford-Burnham, creating the best available data to share with the general scientific community, including pharmaceutical companies.

"We hope to put the scientific and technical competency of chemical biology at Sanford-Burnham to work in this study, helping to generate prototypes of new medicines that could eventually be delivered to patients who desperately need them," said Dr. Kristiina Vuori, M.D., Ph.D., Sanford-Burnham's President and Director of its NCI-designated Cancer Center.

In addition, the study team will meet monthly with the NCI's Cancer Target Discovery and Development (CTDD) Network, sharing best practices that will help other researchers avoid duplication and pursue the most promising lines of investigation. The CTDD Network goal is to bridge the gap between the enormous volumes of genomic data generated by the comprehensive molecular characterization of various cancer types and the ability to use these data for the development of human cancer therapeutics.

"The computational tools we have developed to enable personalized medicine will comb through extensive data sets, looking to systematically identify novel drug targets and match the best available therapies with patients' individual tumors," said Dr. Craig Webb, Ph.D., Head of VARI's Laboratory of Translational Medicine, which brings to the study expertise in bioinformatics and personalized medicine. "Working closely with the CTDD Network will ensure that our ongoing research remains cutting-edge."

In addition to the team led by TGen, the CTDD Network consists of: Columbia University, Emory University, the Dana-Farber Cancer Institute, University of California San Francisco, Universit
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Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

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