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TGen findings contribute to understanding of diabetic kidney disease
Date:4/22/2011

Through RNA interference, which helps control which genes are active and the degree of their activity, researchers reduced the expression of PVT1, which in turn reduced the protein levels of ECM components.

In a related finding, TGen scientists discovered that PVT1 affects the expression of other genes FN1, COL4A1 and PAI-1 in a manner that is at least partially independent of TFFB1, a gene associated with tissue fibrosis, or tissue damage.

"Delineation of the relationship between TGFB1 and PVT1 represents a critical component toward understanding the molecular mechanisms underlying the regulation of ECM in diabetic nephropathy," said Dr. Lucrecia Alvarez, the study's lead author and a TGen post-doctoral fellow.


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Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

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