Navigation Links
TGen and Washington University researchers discover new approach to treating endometrial cancer
Date:8/31/2008

, in cases where the tumors contained the altered FGFR2 gene. The altered gene causes the receptors to get stuck in the "on'' position and signal the endometrial cells to grow out of control.

"These findings could accelerate the development of new treatments for endometrial cancer because there are already drugs in clinical trials that inhibit FGFR2 function,'' Pollock said.

Current treatment of endometrial cancer can involve surgical removal of the uterus, radiation and chemotherapy. While many women are successfully treated with these approaches, about 15 percent of those with endometrioid endometrial cancer have persistent or recurring tumors that are resistant to current drug therapies. Mutations in several genes previously have been identified in endometrial tumors, but they have not been suitable drug targets until now.

"This targeted approach holds great promise for patients with uterine cancer (endometrioid endometrial) tumors that contain the FGFR2 mutation," said TGen physician-in-chief, Dr. Daniel Von Hoff, "and offers yet another powerful example of how genomic medicine is changing the way we look at and treat cancer."

Goodfellow agreed, "The discovery that endometrial cancer cells die when treated with an FGFR2 inhibitor - even when they carry other genetic abnormalities common in uterine cancers - suggests anti-FGFR2 therapies have great potential.''

The researchers' already established ties with the National Cancer Institute, which will assist with the clinical trials, should speed the development of new therapies, Goodfellow said. "Our collaborative group's strong ties with the NCI's Gynecologic Oncology Group will allow us to rapidly take our findings from the lab to patients.''

Endometrial cancer, which invades the inner wall of the uterus, is the most common gynecological cancer in the United States. This year more than 40,000 women will be diagnosed and nearly 7,500 women will die of the dis
'/>"/>

Contact: Galen Perry
gperry@tgen.org
602-343-8423
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. First IEEE-USA Innovation Forum coming to Washington area in November
2. DHS Begins Collecting 10 Fingerprints From International Visitors at Washington Dulles International Airport
3. Washington University, 2 industries, team to clean up mercury emissions
4. Missouri board grants Washington University Sustainability Center $3 million
5. Washington University increases fleet of Roche Genome Sequencer FLX Systems
6. Washington University unveils draft sequence of corn genome
7. 5th Annual World Health Care Congress April 21-23, Washington, D.C.
8. Analysis of Lake Washington microbes shows the power of metagenomic approaches
9. A study by the MUHC and McGill University opens a new door to understanding cancer
10. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
11. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... nature, the right amount of death at the right ... according to new research that could help in understanding ... stocks. , In a paper in the journal ... researcher and European colleagues conclude that the kind of ... loss of individuals, or mortality, depends on the size ...
(Date:11/4/2014)... A majority of Madagascar,s 101 species of lemurs are ... for the rainforests they call home. A new study ... can have on rainforest tree populations, which raises concerns ... the region,s rich biodiversity. , A large proportion of ... Lemurs in turn disperse the seeds of their ...
(Date:11/3/2014)... weight and preterm birth are linked to increased risk ... in the American College of Rheumatology (ACR) journal, ... weight and pre-term babies were not at greater risk ... , According to the ACR, 27 million Americans over ... Symptoms of OA range from mild to severe and ...
Breaking Biology News(10 mins):When less is more: Death in moderation boosts population density in nature 2Gardeners of Madagascar rainforest at risk 2Gardeners of Madagascar rainforest at risk 3Preterm, low birth-weight babies may need new hips in adulthood 2
... incredibly temperature sensitive and can perceive changes of as little ... 8th issue of the journal Cell , a Cell ... rise, but also coordinate an appropriate response -- activating hundreds ... about the way that their DNA is packaged. The ...
... gardening world it may have always been considered a fact, ... watering your garden in the midday sun can lead to ... in New Phytologist , provides an answer that not ... for forest fires and human sunburn. "The problem ...
... project E! 3184 Odysseus has developed systems to ... tumours or other pathologies, from MRI or CT-scans. The ... location, for consultation in real time just before surgery. ... with the best possible diagnostic support, before real surgery ...
Cached Biology News:How plants 'feel' the temperature rise 2Can a drop of water cause sunburn or fire? 2A virtual liver, a better chance of life 2A virtual liver, a better chance of life 3
(Date:11/26/2014)... IL (PRWEB) November 26, 2014 In ... is giving customers a bevy of last-minute Thanksgiving savings. ... codes and offers across all product lines this holiday ... , Thanksgiving, Black Friday, and Cyber Monday are ... its' own thanks to both loyal customers and those ...
(Date:11/26/2014)... Baltimore, MD (PRWEB) November 26, 2014 ... invite the Baltimore and Washington D.C. science community ... research. , The event, sponsored by the Protein Society, ... in UMBC’s University Center, Room 312. Through discussion, ... functional and structural importance of proteins, their role in ...
(Date:11/26/2014)... 25, 2014 SonaCare Medical, a ... (HIFU) devices, recently participated in the American Urology ... 360° .” Key opinion leaders in urology presented ... to small renal masses while attendees had the ... technologies in hands-on labs. Attendees at the Los ...
(Date:11/26/2014)... Global biostimulants market is expected to reach $2,524.02 ... of 12.5%. In order to cater to the ... impacts, farmers are looking to adopt natural compounds ... effectively & efficiently. Biostimulants are consequently seen as ... investments. , Leading companies in the biostimulants market ...
Breaking Biology Technology:DNA Spectrum Offers Last Minute Thanksgiving Coupons 2DNA Spectrum Offers Last Minute Thanksgiving Coupons 3SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 32019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 22019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 32019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 4
... 2011 The New York Stem Cell Summit is releasing ... the press and the general public understand more accurately the ... the United States today. Approximately 1 million patients ... mid-1980s in the United States. Harvesting stem ...
... 2011 Renmatix , the leading producer of cellulosic sugars, ... fuels company Amyris , has joined the Renmatix Board of ... Year" by the Philadelphia Business Journal , will fill the ... Melo comes to the Renmatix Board of Directors with rare ...
... Sept. 13Researchers at Vanderbilt University have developed a new technique ... biological tissue at multiple points simultaneously, a method that could ... grow and change shape. UV lasers are a ... make incisions by vaporizing one point at a time in ...
Cached Biology Technology:New York Stem Cell Summit Issues Adult Stem Cell Fact Sheet 2Amyris Chief Joins Renmatix BoD, New CFO Added to Company 2