Navigation Links
TGen and Washington University researchers discover new approach to treating endometrial cancer
Date:8/31/2008

, in cases where the tumors contained the altered FGFR2 gene. The altered gene causes the receptors to get stuck in the "on'' position and signal the endometrial cells to grow out of control.

"These findings could accelerate the development of new treatments for endometrial cancer because there are already drugs in clinical trials that inhibit FGFR2 function,'' Pollock said.

Current treatment of endometrial cancer can involve surgical removal of the uterus, radiation and chemotherapy. While many women are successfully treated with these approaches, about 15 percent of those with endometrioid endometrial cancer have persistent or recurring tumors that are resistant to current drug therapies. Mutations in several genes previously have been identified in endometrial tumors, but they have not been suitable drug targets until now.

"This targeted approach holds great promise for patients with uterine cancer (endometrioid endometrial) tumors that contain the FGFR2 mutation," said TGen physician-in-chief, Dr. Daniel Von Hoff, "and offers yet another powerful example of how genomic medicine is changing the way we look at and treat cancer."

Goodfellow agreed, "The discovery that endometrial cancer cells die when treated with an FGFR2 inhibitor - even when they carry other genetic abnormalities common in uterine cancers - suggests anti-FGFR2 therapies have great potential.''

The researchers' already established ties with the National Cancer Institute, which will assist with the clinical trials, should speed the development of new therapies, Goodfellow said. "Our collaborative group's strong ties with the NCI's Gynecologic Oncology Group will allow us to rapidly take our findings from the lab to patients.''

Endometrial cancer, which invades the inner wall of the uterus, is the most common gynecological cancer in the United States. This year more than 40,000 women will be diagnosed and nearly 7,500 women will die of the dis
'/>"/>

Contact: Galen Perry
gperry@tgen.org
602-343-8423
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. First IEEE-USA Innovation Forum coming to Washington area in November
2. DHS Begins Collecting 10 Fingerprints From International Visitors at Washington Dulles International Airport
3. Washington University, 2 industries, team to clean up mercury emissions
4. Missouri board grants Washington University Sustainability Center $3 million
5. Washington University increases fleet of Roche Genome Sequencer FLX Systems
6. Washington University unveils draft sequence of corn genome
7. 5th Annual World Health Care Congress April 21-23, Washington, D.C.
8. Analysis of Lake Washington microbes shows the power of metagenomic approaches
9. A study by the MUHC and McGill University opens a new door to understanding cancer
10. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
11. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... are good examples of complex systems. Their infrastructure ... water for cooling, transport to supply fuel, and ... in the network chain is interconnected with a ... A team of UK-based scientists has studied various ... findings have been published in EPJ B by ...
(Date:8/28/2014)... health risk to people with asthma according to a new ... Immunology . , By critically reviewing the findings from 17 ... the presence of several types of mould can lead to ... likelihood of developing the condition. , The research has been ... School and is the first time all of the information ...
(Date:8/28/2014)... important crop-producing countries will be fully saturated with pests ... continue, according to a new study led by the ... can already be found in around half the countries ... at its current rate, scientists fear that a significant ... pests within the next 30 years. , Crop pests ...
Breaking Biology News(10 mins):Inter-dependent networks stress test 2Indoor mold poses health risk to asthma sufferers 2New study charts the global invasion of crop pests 2
... new study published in the Journal of Trauma ... (DP) stimulation in spinal cord-injured patients is successful not ... in bridging patients to independent respiration, where they could ... ventilator or stimulation. The stimulation is provided by ...
... , (Santa Barbara, Calif.) As the Endangered Species Act (ESA) ... agency, the U.S. Fish and Wildlife Service (USFWS), was mired in ... ( Canis lupus ) from the List of Endangered and Threatened ... baileyi ). As a result, the USFWS sought an ...
... the right shape might be just as important in a ... an important role in the effectiveness of cells grown to ... design new structures that enable cells to "shape up," researchers ... come up with a way to measure, and more importantly, ...
Cached Biology News:Diaphragm pacing in spinal cord injury successful in weaning patients from ventilators 2Diaphragm pacing in spinal cord injury successful in weaning patients from ventilators 3Panel issues report on gray wolf science 2Shape-sifting: NIST categorizes bio scaffolds by characteristic cell shapes 2
(Date:8/28/2014)... August 28, 2014 Supplementing their ... a promotion for Eppendorf Safe Lock Centrifuge ... purchase the highest quality tubes at an affordable ... for customers doing chemical, medical, pharmaceutical, and life ... are not regularly able to afford Eppendorf products. ...
(Date:8/27/2014)... Green & Grow Inc. (GGI) has raised an ... Otter Capital as a significant new partner. Otter Capital’s ... Agriplier™ technology, building on recent compelling field trial results ... meeting, we have been impressed with Otter Capital’s knowledge ... Sobba, President and CEO of GGI. “We look forward ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com ... is available in its catalogue: ... http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html ... materials that are readily decomposed by the ... conventional non-degradable packaging in terms of raw ...
(Date:8/27/2014)... TX (PRWEB) August 27, 2014 The ... and in-depth study on the current state of the ... report provides a basic overview of the industry, including ... and Chinese domestic market analysis are provided with a ... the market. A comparison between the international and Chinese ...
Breaking Biology Technology:Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7Trifluoroacetic Acid Industry (Asia, Europe, North America, ROW) Analysis Report Now Available at ReportsnReports.com 2
... Madison, Wis . - If manufacturers are interested in new ... a conference that provides a learning and technology transfer opportunity. ... already puts on an annual design event at the ... expanded the program with the intention of opening doors to ...
... some one thousand theme-based cities being developed at a phenomenal ... name identities of such projects become nightmares. In size, they ... large dwelling. , ,Now this requires a new definition of ... other traditional metropolises. , ,For example, the introduction of ...
... reported net income of $113.5 million during the first quarter ... rising 11 percent over the same quarter in 2006. , ... industry, said net income was down from the $116.2 million ... share were slightly higher than the $0.64 in the same ...
Cached Biology Technology:Branding around the community brand concept 2Branding around the community brand concept 3
...
... multi-channel focal drug delivery. Maintain bath temperature ... bath line while quickly switching 4 or ... Steady 37°C at 5 ml/minute flow rates ... Advanced auto-tuning temperature lock ...
...
... recombinant human angiogenin expressed in ... Physical form: Lyophilized from a ... phosphate buffered saline. Titertest ... Titertest values: capture ELISA ...
Biology Products: