Navigation Links
TGen and Washington University researchers discover new approach to treating endometrial cancer
Date:8/31/2008

PHOENIX, Ariz. Sept. 1, 2008 Researchers at the Translational Genomics Research Institute (TGen) today announced a new approach to treating endometrial cancer patients that not only stops the growth of tumors, but kills the cancer cells.

In a potentially major breakthrough, TGen scientists and collaborators at Washington University School of Medicine in St. Louis discovered that introducing a particular inhibitor drug can turn "off'' receptors responsible for the growth of tumors in a significant number of patients with endometrial cancer.

And, they found that the inhibitor drug proved effective even in cancer tumors containing a commonly occurring mutant gene, PTEN, previously associated with resistance to drug treatment.

TGen's findings appear today in a paper published as a priority report by Cancer Research, a Philadelphia-based peer-reviewed journal dedicated to original cancer research.

A clinical trial based on the TGen study will start within the next year.

Dr. Pamela Pollock, an associate investigator in TGen's Cancer and Cell Biology Division and the paper's senior author, led a team that used the latest genome-scanning technology to sequence 116 endometrioid endometrial tumor samples. This work was done in association with Dr. Paul Goodfellow, an expert in endometrial cancer and a professor in the departments of Surgery and of Obstetrics and Gynecology at Washington University.

Pollock and colleagues in May 2007 announced that they had discovered previously unrecognized alterations in the fibroblast growth factor receptor 2 (FGFR2) gene. The altered FGFR2 is present in the cancer cells of nearly 15 percent of women with endometrioid endometrial tumors. These kinds of tumors represent 80 percent of all endometrial cancers.

By introducing a commercially available inhibitor drug, PD173074, TGen researchers showed that they could stop the growth of tumors, and even kill cancer cells
'/>"/>

Contact: Galen Perry
gperry@tgen.org
602-343-8423
The Translational Genomics Research Institute
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. First IEEE-USA Innovation Forum coming to Washington area in November
2. DHS Begins Collecting 10 Fingerprints From International Visitors at Washington Dulles International Airport
3. Washington University, 2 industries, team to clean up mercury emissions
4. Missouri board grants Washington University Sustainability Center $3 million
5. Washington University increases fleet of Roche Genome Sequencer FLX Systems
6. Washington University unveils draft sequence of corn genome
7. 5th Annual World Health Care Congress April 21-23, Washington, D.C.
8. Analysis of Lake Washington microbes shows the power of metagenomic approaches
9. A study by the MUHC and McGill University opens a new door to understanding cancer
10. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
11. University of Oregon researcher finds that on waters surface, nitric acid is not so tough

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/23/2009).... November 23, 2009 Applied mathematicians disse...ancifolia ), a characteristic long leaf with a sad... along the edges. The simple cause of the lily,s f...ding during differential growthwas revealed by usi...bbons. , Haiyi Liang, a postdoctoral student at ...
(Date:11/23/2009)...e Wildlife Conservation Society says that western ...public of Congopart of the "mother lode" of more t...ing increasingly threatened by growing humans acti...ction of the swamp forests adjacent to the southwe... surveys confirmed that high densities of the grea...
(Date:11/23/2009)...rent research suggests that a common oral bacteriu...report by Nichols et al, "Unique Lipids from a Com...Ligands Capable of Enhancing Autoimmunity," appear...nal of Pathology . , Multiple sclerosis (MS), a ...and spinal cord, affects nearly 1 in 700 people in...
Breaking Biology News(10 mins):The cause behind the characteristic shape of a long leaf revealed 2A year after discovery, Congo's 'mother lode' of gorillas remains vulnerable 2Factors from common human bacteria may trigger multiple sclerosis 2Arcadia Resources Announces Closing of 2411 1 Million Financing 61915 1Arcadia Resources Announces Closing of 2411 1 Million Financing 61915 2Inimex Announces Appointment of New CEO 14941 1Inimex Announces Appointment of New CEO 14941 2Pearl Therapeutics Appoints Howie Rosen to Board of Directors 14939 1Pearl Therapeutics Appoints Howie Rosen to Board of Directors 14939 2
...le ways and, because of this, restoration ecologis...searchers, in a recent article published in Restor...he past may not always be applicable in the future...is restoring environments undergoing the most rapi...bal climate change is likely to have important reg...
...ike creating a topiary garden. Shrubs don,t automa...and neither do immature nerve cells immediately re... either vegetal or neuronal, must first sprout and...rons extend fibers called axons to target cells in...ells while others shoot past their target cells. A...
...HIV-1--the virus predominantly responsible for hum... new evidence reveals. A gene function lost during...o spur the fatal immune system failures that are t...ne 16, 2006 Cell. , AIDS has killed more than 25 m...1, according to The Joint United Nations Programme...
Other Biology News:Salk and Stanford teams join forces to reveal two paths of neurodegeneration 2Salk and Stanford teams join forces to reveal two paths of neurodegeneration 3HIV-1's high virulence might be an accident of evolution 2HIV-1's high virulence might be an accident of evolution 3HIV-1's high virulence might be an accident of evolution 4
(Date:11/24/2009)...CALGARY and BLENHEIM, Ontario, Nov. 24 /PRNewswire...oday it is acquiring the assets of Hyland Seeds, a...o. The addition of Hyland Seeds will further expan...company anticipates the introduction of SmartStax...olerant Trait Technology in corn in 2012. The tran...
(Date:11/24/2009)..., SHANGHAI, Nov. 24 /PRNewswire-Asia/ -- NOD ... Trademark Office (PTO) has allowed the patent app...D technology. , NOD technology is a highl...oteins into bio-adhesive nano-particles to enable ...njections. NOD technology is a platform technology...
(Date:11/24/2009)... , Primary efficacy endpoint has been met for p...etrial cancer, , QUEBEC CITY, Nov. 24 /PRNews...AEZS ; TSX: AEZ) (the "Company"), a global biophar...d oncology, today announced positive efficacy data...peptide conjugate, AEZS-108 (formerly AN-152), in ...
(Date:11/24/2009)...N,Italy,November24/PRNewswire/--HealthRoboticstoda...withagroupofselected,investors.ThisrecentlyformedT...oboticsCanada,Inc.andwillmarket,install,andsupport...cludesthe,revolutionaryproductofferingsi.v.STATION...Inc.willalsoprovideassistanceonan"asneeded,basis"t...
Breaking Biology Technology:Dow AgroSciences Canada Announces Agreement to Acquire Hyland Seeds 2Dow AgroSciences Canada Announces Agreement to Acquire Hyland Seeds 3AEterna Zentaris Announces Positive Results for Phase 2 Study with LHRH-Receptor Targeted Cytotoxic Conjugate AEZS-108 in Endometrial Cancer 2AEterna Zentaris Announces Positive Results for Phase 2 Study with LHRH-Receptor Targeted Cytotoxic Conjugate AEZS-108 in Endometrial Cancer 3AEterna Zentaris Announces Positive Results for Phase 2 Study with LHRH-Receptor Targeted Cytotoxic Conjugate AEZS-108 in Endometrial Cancer 4Health Robotics Continues its Global Expansion With December 09 ASHP's Launch of Joint Venture in Canada 2
...pace, the world,s leading,online bioscience job bo...,announced today an alliance with IBC Life Science...eer Fair in conjunction with IBC,s Drug Discovery,...gress (DDT) in Boston,during August of 2008., The...0 life science,professionals from the BioSpace com...
... & high-tech market will grow to over $2 bi...oup, WALTHAM, Mass., April 17 According to Mille...n and High-Tech Devices 2008,and European Markets ...ts,the visualization device market in these region... 2007. This market will see rapid growth, driven b...
...tees Will Solve and Prevent Crimes, CARLSBAD, N.M...joined together in praising the efforts of US Atto... rule that will finally allow,implementation of fo...in,late 2005. These families have each been active...es. The federal law requires a DNA sample from any...
Other Biology Technology:BioSpace and IBC Life Sciences Announce Career Fair Alliance For Drug Discovery & Development of Innovative Therapeutics World Congress 2BioSpace and IBC Life Sciences Announce Career Fair Alliance For Drug Discovery & Development of Innovative Therapeutics World Congress 3High-Definition Technology to Revolutionize US & European Visualization Device Markets 2Mothers of Victims Applaud Federal Effort to Collect DNA Upon Arrest 2
PlateCrane EX from Hudson Control Group, Inc.
4% Agarose Gel from Invitrogen
BD BaculoGold Max-XP Insect Cell Medium from BD Biosciences Pharmingen
GIBCO Newborn Calf Serum; Heat-Inactivated from Invitrogen
Biology Products: