Navigation Links
TGen and Washington University researchers discover new approach to treating endometrial cancer
Date:8/31/2008

PHOENIX, Ariz. Sept. 1, 2008 Researchers at the Translational Genomics Research Institute (TGen) today announced a new approach to treating endometrial cancer patients that not only stops the growth of tumors, but kills the cancer cells.

In a potentially major breakthrough, TGen scientists and collaborators at Washington University School of Medicine in St. Louis discovered that introducing a particular inhibitor drug can turn "off'' receptors responsible for the growth of tumors in a significant number of patients with endometrial cancer.

And, they found that the inhibitor drug proved effective even in cancer tumors containing a commonly occurring mutant gene, PTEN, previously associated with resistance to drug treatment.

TGen's findings appear today in a paper published as a priority report by Cancer Research, a Philadelphia-based peer-reviewed journal dedicated to original cancer research.

A clinical trial based on the TGen study will start within the next year.

Dr. Pamela Pollock, an associate investigator in TGen's Cancer and Cell Biology Division and the paper's senior author, led a team that used the latest genome-scanning technology to sequence 116 endometrioid endometrial tumor samples. This work was done in association with Dr. Paul Goodfellow, an expert in endometrial cancer and a professor in the departments of Surgery and of Obstetrics and Gynecology at Washington University.

Pollock and colleagues in May 2007 announced that they had discovered previously unrecognized alterations in the fibroblast growth factor receptor 2 (FGFR2) gene. The altered FGFR2 is present in the cancer cells of nearly 15 percent of women with endometrioid endometrial tumors. These kinds of tumors represent 80 percent of all endometrial cancers.

By introducing a commercially available inhibitor drug, PD173074, TGen researchers showed that they could stop the growth of tumors, and even kill cancer cells
'/>"/>

Contact: Galen Perry
gperry@tgen.org
602-343-8423
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. First IEEE-USA Innovation Forum coming to Washington area in November
2. DHS Begins Collecting 10 Fingerprints From International Visitors at Washington Dulles International Airport
3. Washington University, 2 industries, team to clean up mercury emissions
4. Missouri board grants Washington University Sustainability Center $3 million
5. Washington University increases fleet of Roche Genome Sequencer FLX Systems
6. Washington University unveils draft sequence of corn genome
7. 5th Annual World Health Care Congress April 21-23, Washington, D.C.
8. Analysis of Lake Washington microbes shows the power of metagenomic approaches
9. A study by the MUHC and McGill University opens a new door to understanding cancer
10. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
11. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... members to reduce aggression and gain access to scarce ... activities shows a certain pattern across the day. The ... Biology Letters . , Grooming between individuals in a ... To be groomed has hygienic benefits and is stress ... provide access to infants, mating opportunities and high quality ...
(Date:7/11/2014)... have explored two different ways that allow unprecedented ... the formation of oxygen molecules in photosynthesis. The ... journal Nature Communications . , "The new ... for water oxidation, which are key components for ... of solar energy in fuels like hydrogen, ethanol ...
(Date:7/11/2014)... kidney injury related to the use of hydroxyethyl starch ... molecules, according to a report in Anesthesia & ... Society (IARS). , The "total mass of HES molecules" ... renal proximal tubule cells (PTCs), concludes the laboratory study ... Wrzburg, Austria. Other factorssuch as differences in the ...
Breaking Biology News(10 mins):Baboons groom early in the day to get benefits later 2Molecular snapshots of oxygen formation in photosynthesis 2In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2
... new study on identifying which patients were likely to ... found that measuring how a certain non-toxic dye was ... accurate indicator of liver function, and therefore a reliable ... used a simple non-invasive device to measure the dye, ...
... predators at the top of the marine food chain, ... mercury in their bodies. A new study has found ... albatross species that forage in different areas of the ... and DDT have increased in both species over the ...
... ago, humans began scrubbing off and discarding the outer ... beneath. Now, for the first time, scientists in Japan ... called rice bran, significantly lowers blood pressure in rats ... reports their findings in the March 8 issue of ...
Cached Biology News:Predicting successful outcomes in living-donor liver transplants 2Predicting successful outcomes in living-donor liver transplants 3Albatross study shows regional differences in ocean contamination 2Albatross study shows regional differences in ocean contamination 3How nice, brown rice: Study shows rice bran lowers blood pressure in rats 2
(Date:7/11/2014)... WEST PALM BEACH, Fla. , July 11, 2014 ... wide variety of high-quality peptides that are used solely ... online. To honor two successful years in business, Maxim ... Performance LLC, has just launched a new and updated ... addition, the research blog section has been updated with ...
(Date:7/11/2014)... DUBLIN , July 11, 2014 ... "International Transfection Technology Market - Global Industry Analysis, ... report to their offering. ... to introduce nucleic acids (either DNA or RNA) into ... therapy, mutation of cancer cells and protein metabolism by ...
(Date:7/11/2014)... -- EPFL and the University of  Geneva ... John P. Donoghue . The American neuroscientist is to ... The new Wyss Center for Bio- and ... , has named as its director one of ... , founder of Brown University,s Institute for Brain Science, ...
(Date:7/11/2014)...  Researchers have pioneered a revolutionary new way ... called Virtual Finger, allows scientists to move through ... synapses using the flat surface of their computer ... studies orders of magnitude more efficient, saving time, ... many areas of experimental biology. The software and ...
Breaking Biology Technology:Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 3Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3
... provide cost-efficient, easy to use ... sputum samples for testing, ALBUQUERQUE, N.M., Feb. 13 ... patented early lung cancer detection,testing and other cancer diagnostic ... to collect lung sputum,samples in an upcoming clinical study ...
... therapeutic antibody to be presented at AACR ... Special Conference on Cancer Stem Cells -, TORONTO, ... company discovering and developing the next wave of,antibody therapeutics, today ... cancer stem cell antibody will be,presented at the AACR Special ...
... Cellegy,Pharmaceuticals, Inc. (OTC Bulletin Board: CLGY) today ... merger agreement providing for the,acquisition of Cellegy ... held specialty pharmaceuticals company that is engaged ... for the prevention,of viral infections, including influenza. ...
Cached Biology Technology:Biomoda and Medical Acoustics Partner in Study for Early Detection of Lung Cancer in Veterans 2Biomoda and Medical Acoustics Partner in Study for Early Detection of Lung Cancer in Veterans 3ARIUS presents new findings showing therapeutic antibody inhibits human leukemic cancer stem cells 2ARIUS presents new findings showing therapeutic antibody inhibits human leukemic cancer stem cells 3ARIUS presents new findings showing therapeutic antibody inhibits human leukemic cancer stem cells 4Cellegy Pharmaceuticals Announces Signing of Definitive Merger Agreement 2Cellegy Pharmaceuticals Announces Signing of Definitive Merger Agreement 3Cellegy Pharmaceuticals Announces Signing of Definitive Merger Agreement 4Cellegy Pharmaceuticals Announces Signing of Definitive Merger Agreement 5Cellegy Pharmaceuticals Announces Signing of Definitive Merger Agreement 6
... many modifications to the original formulas in efforts ... play an important role in tissue,culture. A salt ... osmotic balance in the medium and to provide ... is as valuable today as when it was ...
Imject Freund's Complete Adjuvant (FCA)...
... long and short-term enriched housing for nonhuman ... quarantine and non-quarantine settings on a per ... utilizing our state-of-the-art social housing and nursery ... on site CDC quarantine facilities. Primate ...
... exceptionally sensitive nucleic acid gel stain has bright ... in gels, making it ideal for detecting dsDNA ... transilluminators. SYBR Green I nucleic gel acid ... electrophoresis, real-time PCR assays and bandshift assays. One ...
Biology Products: