Navigation Links
TGen and NAU patent for new pandemic flu test is approved
Date:10/8/2014

FLAGSTAFF, Ariz. — Oct. 8, 2014 — The federal government has awarded a patent to the Translational Genomics Research Institute (TGen) and Northern Arizona University (NAU) for a test that can detect — and assist in the treatment of — the H1N1 pandemic flu strain.

TGen and NAU initially developed this precise, genomics-based test during a significant global swine flu outbreak in 2009.

The newly-patented test, developed at TGen's Pathogen Genomics Division (TGen North) in Flagstaff, can not only detect influenza — as some tests do now — but also can quickly inform doctors about what strain of flu it is, and whether it is resistant to oseltamivir (sold by Roche under the brand name Tamiflu), the primary anti-viral drug on the market to treat H1N1.

As with other influenza strains, H1N1 flu can over time be expected to show signs of resistance to oseltamivir, and new treatments will be needed to respond to future pandemics.

"The problem with influenza is that it can become resistant to the antiviral drugs that are out there," said Dr. Paul Keim, Director of TGen North, a Regents Professor of Biology at NAU and one of the test's inventors. "Because it is a virus, it easily mutates and becomes resistant."

David Engelthaler, Director of Programs and Operations for TGen North and another of the test's inventors, said this flu detection and susceptibility test uses a molecular technique that rapidly makes exact copies of specific components of H1N1's genetic material.

"Many people, including physicians, don't realize that the pandemic swine flu strain from 2009 is still the most important flu strain out there. This assay is very effective with detecting and characterizing this dominant strain in the U.S. and around the world," said Engelthaler, the former State Epidemiologist for Arizona, and former State of Arizona Biodefense Coordinator.

The third inventor of the test is TGen North Lab Manager Elizabeth Driebe.

Previously, only the U.S. Centers for Disease Control Prevention (CDC) and a few select labs could look for resistance, using time-intensive technology.

"This new test puts the power in the hands of the clinician to determine if their drugs will work or not. This is really important moving forward as we discover new strains that are resistant to antivirals," Engelthaler said.

The World Health Organization (WHO) has identified dozens of instances in which H1N1 was resistant to Tamiflu.

At most doctors' offices, there is no readily available test for H1N1. Such tests generally are conducted by state and federal health agencies, and usually for those patients who require hospitalization and appear at high risk because they have a suppressed immune system or they have a chronic disease.

"Our test measures minute amounts of virus and minute changes to the virus. Not only does it detect when resistance is occurring, but it also detects it at the earliest onset possible," Engelthaler said.

This new patent — No. US 8,808,993 B2, issued Aug. 19 by the U.S. Patent and Trademark Office — could be licensed for development of test kits or for development of a testing service.

Earlier this year, TGen-NAU celebrated its first joint patent for a genomics-based test that can identify most of the world's fungal infections that threaten human health.


'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute

Source:Eurekalert

Related biology news :

1. Bio researchers receive patent to fight superbugs
2. Profile Solutions, Inc Signs Exclusive Worldwide License for Patented Technology and Intellectual Property
3. NXT-ID Patents Offline Local Identity Validation and Fraud Prevention System
4. Emotient Gains Exclusive Rights to New, Expansive Patent Issued for Automated Facial Action Coding System
5. Biometrics Tech Companies Move Toward Mobile Payment Products with New Smart Wallet Options: New Patent Application to Integrate Intelligent Systems for Newest Smart Wallet
6. New patenting guidelines are needed for biotechnology
7. Patented research remotely detects nitrogen-rich explosives
8. Discovery leads to patent for novel method of treating traumatic brain injury
9. Whos patenting whose genome?
10. LaserLock Technologies Files A New Provisional Patent Which Secures Player Identity On Internet Gaming Platforms
11. hESC Products Market: Human Embryonic Stem Cell Patent IP Landscape Opportunity Analysis in New Research Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2019)... ... ... Lighting designers from integrated design firm LPA recently earned two ... both engaging and energy efficient lighting systems. , The lighting for the repositioning of ... California earned an IES Illumination Award of Merit in the Energy and Environment category. ...
(Date:6/20/2019)... ... 19, 2019 , ... The half-million dollars in Alzheimer’s disease ... and the possibly millions of dollars of “high priority” grants now offered by ... “welcome affirmation” of the need to investigate more thoroughly the possible roles of ...
(Date:6/16/2019)... (PRWEB) , ... June 14, 2019 , ... ... Americans invited to lecture at the fifth annual Neodent World Congress. Attended by ... the innovative progress and latest advancements in the world of dentistry. The three-day ...
Breaking Biology News(10 mins):
(Date:7/17/2019)... SOMERSET, N.J. (PRWEB) , ... ... ... today announced a long-term strategic agreement for the development and manufacturing of ... (SMA). , Through this collaboration, AveXis, a Novartis company, will have dedicated ...
(Date:7/9/2019)... ... July 08, 2019 , ... Balluff ... Indicator was recognized as the 2019 Innovative Product of the Year which highlights ... awards were during Sensors Expo & Conference 2019, held this week ...
(Date:6/18/2019)... ... ... Personalized Stem Cells, Inc (“PSC”), a human adipose-derived stem cell ... of a person’s own adipose-derived stem cells to treat their osteoarthritis. The first clinical ... IND is the first of several planned clinical trials which will enable qualified PSC-enrolled ...
(Date:6/11/2019)... (PRWEB) , ... June 10, 2019 , ... ... announced IOPP will add 80 of its scientific journals to DeepDyve’s rental service ... content to DeepDyve’s continually expanding library of more than 20 million articles, sourced ...
Breaking Biology Technology: