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TGen and Genomic Health Inc. discover genes affecting cancer drug
Date:1/13/2011

ells' DNA and inhibiting the cancer cells' ability to reproduce and survive, the study said. This study has also showed that diverse gene networks also play a role in the ability of the drug to impact colon tumors.

"These 27 genes, whose loss of function significantly affect the effectiveness of oxaliplatin, may be promising therapeutic biomarkers for oxaliplatin," said Dr. Holly Yin, head of TGen's Cellular Genomics Collaborative Center in Scottsdale, and a co-author of the study.

Dr. Robert J. Pelham, a research scientist at Redwood City, Calif.-based Genomic Health and the study's senior author, said the findings indicate a need for additional clinical studies on tumor specimens in patients treated with oxaliplatin. "Such future clinical studies could eventually lead to potential clinical applications, where patients could benefit," Dr. Pelham said.


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Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

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