Navigation Links
TGen and Genomic Health Inc. discover genes affecting cancer drug
Date:1/13/2011

PHOENIX, Ariz. Jan. 13, 2011 Genomic research could help doctors better target a drug widely used to treat colorectal cancer patients, according to a study by Genomic Health Inc. (Nasdaq: GHDX) and the Translational Genomics Research Institute (TGen).

The drug, oxaliplatin, is widely used in colon cancer. It is used in early disease, following surgery in those cancers that are likely to recur. It is also used in advanced disease to slow progression of the cancer where it has spread to other parts of the body.

However, a significant number of patients experience serious side effects, including prolonged damage to the nervous system, "creating an urgent need to identify genes that are responsible for drug sensitivity or resistance, which results in directing therapy to those most likely to benefit," according to the study published in Molecular Cancer Research.

Colorectal cancer is the third most common type of cancer in the U.S., annually diagnosed in more than 146,000 Americans. It also is the third highest cause of cancer death in the U.S., annually killing nearly 50,000 people, more than who die each year on the nation's roadways. This cancer affects men and women in nearly equal numbers.

Nerve damage, or neurotoxicity, associated with oxaliplatin is most commonly manifest as pain or a loss of sensation in the hands and feet and can severely affect a patient's quality of life and ability to work. These symptoms are experienced in some form by the majority of patients receiving this drug and, for some patients, can be permanent.

The TGen/Genomic Health researchers examined the role of individual cancer genes to influence the sensitivity or resistance of colon cancer cells grown in laboratory culture. An interfering RNA screen of 500 genes with 2,000 unique siRNA sequences identified 27 genes that, when silenced, altered the sensitivity of colon tumor cells to oxaliplatin, causing damage to the cancer c
'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists decipher 3 billion-year-old genomic fossils
2. Reportlinker Adds Personalized Medicine Market - Advances in Human Genomics and Proteomics to Challenge Traditional Therapeutics
3. Genomic fault zones come and go
4. Salk Institute creates Renato Dulbecco Chair in Genomics and Roger Guillemin Chair in Neuroscience
5. Mississauga teacher awarded prize for excellence in teaching genomics
6. LSU researcher participates in NIH-funded study ushering in the age of personal genomics
7. Structural genomics accelerates protein structure determination
8. Genomic comparison of ocean microbes reveals East-West divide in populations
9. Structural Genomics Consortium releases 1,000th protein structure
10. Genomic haircut makes worlds tiniest genome even smaller: UBC research
11. NIH expands key pharmacogenomics resource
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2015)... OXFORD, Conn. , Jul. 13, 2015 /PRNewswire/ ... the "Company"), a biometric authentication company focused on ... it has filed provisional patent 62/188684 for ... NXT-ID achieves another new convenient and secure method ... expands new, innovative payment methods, introduced with its ...
(Date:7/9/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/98rrmr/biometrics_for ... "Biometrics for Banking; Market & Technology Analysis, Adoption ... offering. The adoption for banking purposes ... the forecast is that by 2020 it will ... in delivering biometric systems to the banking industry. ...
(Date:7/9/2015)... JOSE, Calif. , July 9, 2015 ... the leading developer of human interface solutions, ... technology, the industry,s first fully hardware encapsulated ... Match-in-Sensor secure authentication technology is literally off ... storage and biometric matching within the fingerprint ...
Breaking Biology News(10 mins):NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3
... local waste partnerships towards the achievement of central targets ... objectives, a study funded by the Economic and Social ... disposing of it in environmentally acceptable ways are significant ... public service delivery, partnership working is a now a ...
... tinker with a single amino acid of an enzyme ... to molecular biologists who say the discovery could pave ... making vaccines. "We have successfully tested this technique with ... biochemistry and molecular biology at Penn State. "And we ...
... quench their thirst according to new research by a ... species, including certain types of beetles, moths and crickets, ... account for around 10% of their body weight. The ... simply to get hold of the water in the ...
Cached Biology News:Central targets may hinder wider waste management objectives 2Central targets may hinder wider waste management objectives 3Discovery may help defang viruses 2Discovery may help defang viruses 3Sex is thirst-quenching for female beetles 2
(Date:7/30/2015)... Washington , July 30, 2015 ... Market, by Product (Software, Molecular Modeling, PB/PK, PKPD, Trial ... Discovery & Development, Preclinical, Clinical Trial), by End Users ... Biosimulation Market is expected to reach USD 2,107.99 million ... a CAGR of 15.29%. Browse more ...
(Date:7/30/2015)... ISN improves the efficiency and effectiveness of contractor management systems. ISN,s online contractor management ... over 80 countries. ... ... Over 60,000 Worldwide Customers In More Than 80 Countries ... Dallas, TX , ISN has additional offices in Calgary , ...
(Date:7/30/2015)... ... 30, 2015 , ... As part of its 2015 growth plan and as a follow up ... business units, Whitehouse Laboratories is pleased to announce that it has begun construction on ... of Excellence and will be strictly dedicated to basic USP 51, USP 61, and USP ...
(Date:7/29/2015)... -- According to a new market research report, ... (2015-2020), , published by Mordor Intelligence, the Global market is ... of 2020, with North America being ... the global market size. The Global market for Stem Cells ... the period of (2015-2020).      (Logo: http://photos.prnewswire.com/prnh/20150428/740799) , ...
Breaking Biology Technology:Biosimulation Market Worth 2,107.99 Million USD by 2020 2Biosimulation Market Worth 2,107.99 Million USD by 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 4ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 3
... Va., Oct. 23 Champions,Biotechnology, Inc. (OTC Bulletin ... the appointment of Dr. David,Sidransky, Director of the ... University School of Medicine, to serve as Chairman ... in that capacity since 1991. Dr.,Sidransky was appointed ...
... Presentation on MCSP-specific BiTE Antibody Selected by AACR for Press ... ... Md., Oct. 23 Micromet, Inc.,(Nasdaq: MITI ), a biopharmaceutical ... inflammation and,autoimmune diseases, today announced that data on two antibodies developed,using ...
... Oct. 23 Arbios Systems, Inc.,(OTC: ABOS) today ... agreement with NxStage Medical, Inc., whereby NxStage will,manufacture ... for use,in treating liver failure. Arbios is currently ... to begin a controlled pivotal clinical,trial for SEPET(TM). ...
Cached Biology Technology:Dr. David Sidransky Appointed Chairman of Champions Biotechnology, Inc. 2Dr. David Sidransky Appointed Chairman of Champions Biotechnology, Inc. 3Dr. David Sidransky Appointed Chairman of Champions Biotechnology, Inc. 4Micromet is Presenting Four Posters on BiTE(R) Antibodies at the International AACR-NCI-EORTC Conference 2Micromet is Presenting Four Posters on BiTE(R) Antibodies at the International AACR-NCI-EORTC Conference 3Micromet is Presenting Four Posters on BiTE(R) Antibodies at the International AACR-NCI-EORTC Conference 4Micromet is Presenting Four Posters on BiTE(R) Antibodies at the International AACR-NCI-EORTC Conference 5Arbios Announces SEPET(TM) Manufacturing Agreement With NxStage Medical 2Arbios Announces SEPET(TM) Manufacturing Agreement With NxStage Medical 3Arbios Announces SEPET(TM) Manufacturing Agreement With NxStage Medical 4
... GELase™ Agarose Gel-Digesting Preparation contains a unique ... simple, quantitative recovery of intact DNA and ... gels following electrophoresis in TAE, TBE, MOPS, ... digested directly in the TAE, TBE, MOPS, ...
... Perhaps sheer in-house demand is causing shortages ... precious antibody. This can cause unwanted distractions, problems ... royalties for your hard work and endeavour! Bring ... up and market it internationally. We work under ...
... shortages in your laboratory or fellow researchers want ... problems and delays. • ... Bring us your idea and let us build ... under ISO 9001 quality assurance in design, development, ...
Topoisomerase I...
Biology Products: