Navigation Links
TGen and ASU researchers find drug that could reduce risk of Alzheimer's
Date:2/2/2009

Dr. Heather Bimonte-Nelson, an Assistant Professor in ASU's Department of Psychology and the paper's lead author. "The effects in our aging-animal model were robust, showing enhancements in both learning and two measures of memory. The possibility that these findings may translate to benefits to human brain health and function is very exciting."

In the study, the researchers gave daily injections of hydroxyfasudil to middle-aged (17-18 months old) male rats, starting four days before behavioral testing and continuing throughout testing. Injection made it easy to give the drug to rats, but people take it in the form of a pill.

Rats were tested on a water radial-arm maze, which assessed how well they remembered which of the radiating arms had a reward, a sign of accurate spatial learning and working memory. Rats given a high dose (0.3750 mg per kg of weight) of hydroxyfasudil successfully remembered more items of information than those given a low dose (0.1875 mg per kg). Both dosed groups performed significantly better than control-group rats given saline solution. On this same test, the high-dose group showed the best learning (fewest total errors) and best working memory (measured two different ways).

For every test of learning, the scores of the low-dose group fell between the scores of the no-dose and high-dose groups, meaning that learning and memory boosts depended on the size of the dose.

Fasudil, is used to protect the brain by dilating blood vessels when blood flow is curtailed. In the body, Fasudil breaks down into the more potent hydroxyfasudil molecule, which the authors hypothesize may alter memory by affecting the function of a gene called KIBRA. The authors recently demonstrated that KIBRA might play a role in memory in healthy young and late-middle-aged humans.

Hydroxyfasudil inhibits the activity of Rho-kinase enzymes, which have been shown to inhibit Rac, a vital protein that supports key cellular
'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. LSUSHC researchers find potential new target for hypertension treatment
2. UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
3. What we don’t know still hurts us, environmental researchers warn
4. Researchers unzip molecules to measure interactions keeping DNA packed in cells
5. Researchers may have found why women have an edge on salt-sensitive hypertension
6. Researchers identify new function of protein in cellular respiration
7. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
8. Researchers identify a cell type that limits stroke damage
9. Researchers iron out new role for serotonin
10. Researchers identify 4 genetic hotspots associated with psoriasis
11. Researchers genetically link Lou Gehrigs disease in humans to dog disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... the United States, natural-gas production from shale rock ... 2007. Yet scientists still do not fully understand ... to a report in the journal Frontiers ... gas extraction continues to vastly outpace scientific examination, ... organizations and institutions, including Princeton University, concluded that ...
(Date:7/31/2014)... By tracing nearly 3,000 genes to the earliest ... Florida scientists have created an extensive "Tree of ... next-generation DNA sequencing. , Among the study,s ... to small moths than to large ones, which ... The study also found that some insects once ...
(Date:7/31/2014)... study (HPV-023; NCT00518336) shows the sustained efficacy, ... virus (HPV) vaccine Cervarix. Women vaccinated with ... more than nine years, and vaccine efficacy ... is the longest follow-up report for a ... for the full paper. , HPV ...
Breaking Biology News(10 mins):'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 2'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 3UF study advances 'DNA revolution,' tells butterflies' evolutionary history 2UF study advances 'DNA revolution,' tells butterflies' evolutionary history 3Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 2Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 3
... Head and neck cancer is the sixth most common ... demographic groups, including young women without any known risk factors. ... may increase the movement of precancerous cells in the mouth ... oral cavity. The new results, published in the ...
... adult height may be caused by genetic inheritance, but a ... to be discovered. Now a new meta-analysis of ... over two dozen genes that were not previously associated with ... 30 previously known height genes. "Although the discoveries may not ...
... The hair color of an unknown perpetrator who has ... for forensic investigators. Erasmus MC scientists, in collaboration with their ... predict people,s probable hair color. Their findings will be published ... The research findings demonstrate that on the basis of DNA ...
Cached Biology News:Estrogen may help precancerous cells spread in oral cavity 2CHOP-led study detects dozens of genes for adult height 2CHOP-led study detects dozens of genes for adult height 3Hair color of unknown offenders is no longer a secret 2
(Date:7/31/2014)... global market for molecular diagnostics is expected to reach ... study by Grand View Research, Inc. Growing demand for ... advanced cancer diagnostic technologies are expected to be key ... Moreover, the growing global base of geriatric population and ... lifestyle habits such as smoking and excessive alcohol consumption ...
(Date:7/31/2014)... 31, 2014   BioLife Solutions , Inc. (NASDAQ: ... marketer of proprietary clinical grade hypothermic storage ... thermal shipping products for cells and tissues, today ... results will be released on Thursday, August 7, 2014, ... and live webcast at 4:30 p.m. ET that afternoon. ...
(Date:7/31/2014)... July 31, 2014 Boston’s Adult Stem ... flush with innovative adult stem cell biotechnologies. Currently ... and has three additional patent applications currently under examination ... patented inventions address two of the most vexing problems ... Adult stem cells are difficult to identify; and ...
(Date:7/30/2014)... PARIS , July 30, 2014  Regeneron ... NYSE: SNY) today announced that the Companies intend to ... pediatric disease priority review voucher in connection with the ... review voucher entitles the holder to designate a BLA ... review from the filing date instead of the standard ...
Breaking Biology Technology:Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 2Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 3Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 4Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 5BioLife Solutions to Report Financial Results for Second Quarter 2014 and Provide Business Update on August 7, 2014 2The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 2The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 3Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 2Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 3Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 4Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 5Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 6
... YORK, Sept. 13 Regenicin™, Inc. ... clinical-stage biotechnology company, announced today that John J. Weber, ... Medical Systems, USA, Inc. ("Fujifilm USA"), has agreed to ... of directors and interim Chief Financial Officer.  Weber brings ...
... CLEVELAND, Sept. 13 /PRNewswire/-- DATATRAK International, Inc. (OTCQX: DATA), a ... for the clinical trials industry, announced today that Zacks ... effective September 13, 2010. Zacks is a leading provider ... this research report can be obtained by contacting Mr. ...
... Inc. (OTC Bulletin Board: CSBR ), a company ... specific data to enhance the value of oncology drugs, today ... ended July 31, 2010.  Full details of the Company,s financial ... www.championsbiotechnology.com . Total revenues for the first ...
Cached Biology Technology:Former Fujifilm Medical Systems USA Executive John J. Weber Agrees to Join Regenicin™ as a Member of Its Board of Directors and Interim CFO 2DATATRAK International, Inc. Announces Initial Equity Research Coverage by Zacks Investment Research 2DATATRAK International, Inc. Announces Initial Equity Research Coverage by Zacks Investment Research 3Champions Biotechnology Reports Fiscal 2011 First Quarter Financial Results 2Champions Biotechnology Reports Fiscal 2011 First Quarter Financial Results 3Champions Biotechnology Reports Fiscal 2011 First Quarter Financial Results 4
Mouse monoclonal antibody to PDK2 - pyruvate dehydrogenase kinase, isoenzyme 2...
... cytoplasmic expression of an N-terminal FLAG® fusion ... selection marker from bicistronic mRNA. Two ... MCS2 for transcription of a single message ... useful for protein-protein interaction studies, multi-subunit proteins, ...
Mouse monoclonal antibody raised against a partial recombinant CALCOCO2. NCBI Entrez Gene ID = CALCOCO2...
Mouse polyclonal antibody raised against a partial recombinant KCTD13. NCBI Entrez Gene ID = 253980...
Biology Products: