Navigation Links
TGen and ASU researchers find drug that could reduce risk of Alzheimer's
Date:2/2/2009

Dr. Heather Bimonte-Nelson, an Assistant Professor in ASU's Department of Psychology and the paper's lead author. "The effects in our aging-animal model were robust, showing enhancements in both learning and two measures of memory. The possibility that these findings may translate to benefits to human brain health and function is very exciting."

In the study, the researchers gave daily injections of hydroxyfasudil to middle-aged (17-18 months old) male rats, starting four days before behavioral testing and continuing throughout testing. Injection made it easy to give the drug to rats, but people take it in the form of a pill.

Rats were tested on a water radial-arm maze, which assessed how well they remembered which of the radiating arms had a reward, a sign of accurate spatial learning and working memory. Rats given a high dose (0.3750 mg per kg of weight) of hydroxyfasudil successfully remembered more items of information than those given a low dose (0.1875 mg per kg). Both dosed groups performed significantly better than control-group rats given saline solution. On this same test, the high-dose group showed the best learning (fewest total errors) and best working memory (measured two different ways).

For every test of learning, the scores of the low-dose group fell between the scores of the no-dose and high-dose groups, meaning that learning and memory boosts depended on the size of the dose.

Fasudil, is used to protect the brain by dilating blood vessels when blood flow is curtailed. In the body, Fasudil breaks down into the more potent hydroxyfasudil molecule, which the authors hypothesize may alter memory by affecting the function of a gene called KIBRA. The authors recently demonstrated that KIBRA might play a role in memory in healthy young and late-middle-aged humans.

Hydroxyfasudil inhibits the activity of Rho-kinase enzymes, which have been shown to inhibit Rac, a vital protein that supports key cellular
'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. LSUSHC researchers find potential new target for hypertension treatment
2. UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
3. What we don’t know still hurts us, environmental researchers warn
4. Researchers unzip molecules to measure interactions keeping DNA packed in cells
5. Researchers may have found why women have an edge on salt-sensitive hypertension
6. Researchers identify new function of protein in cellular respiration
7. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
8. Researchers identify a cell type that limits stroke damage
9. Researchers iron out new role for serotonin
10. Researchers identify 4 genetic hotspots associated with psoriasis
11. Researchers genetically link Lou Gehrigs disease in humans to dog disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... sense of fairness did not evolve for the sake ... the benefits of continued cooperation, so say Frans de ... review article about inequity aversion (IA), which is defined ... is published in Science . , Their ... IA-related studies to address their hypothesis that it is ...
(Date:9/19/2014)... which over thousands of years has adapted to the arctic ... makes the cold dangerous for you. , This is happening ... the cold provoking substance, called nonylphenol, comes from the use ... of being a endocrine disruptor, but when entering the worm ... to protect the cells in its body from cold damage. ...
(Date:9/19/2014)... Conn. , Sept. 19, 2014 Nxt-ID, Inc. (Nasdaq: ... biometric authentication company focused on the growing m-commerce market, updates the ... world champion in the lightweight and light middleweight weight classes, ... Yesterday it was announced that Game of Thrones actor ... Married with Children star Katey Sagal have ...
Breaking Biology News(10 mins):Evolution of responses to (un)fairness 2Evolution of responses to (un)fairness 3Environmental pollutants make worms susceptible to cold 2Environmental pollutants make worms susceptible to cold 3NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 2NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 3
... ants it's a way of life! Scientists at the University ... how to visually judge the height of horizontal barriers so ... Tobias Seidl will be presenting his latest research findings at ... Tuesday 4th April. , Desert ants generally scurry around at ...
... pups whose blubber falls below average levels may be at ... they get enough fat in their diets later on, according ... and presented at Experimental Biology 2006. , The study found ... the wild continued to gain weight and grow regardless of ...
... recently discovered cytokine to neural stem cells derived from ... Neurosurgical Institute have developed a tool to track and ... against their return. , Results of an animal study ... Cancer Research, and the researchers are now applying to ...
Cached Biology News:Alaska seal pup diet may hold key to decline of population 2Alaska seal pup diet may hold key to decline of population 3Alaska seal pup diet may hold key to decline of population 4Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection 2Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection 3
(Date:9/18/2014)... SAN DIEGO , Sept. 18, 2014  MEI Pharma, ... on the clinical development of novel therapies for cancer, announced ... Chief Executive Officer, will present at BioCentury,s NewsMakers in ... at 8:30 a.m. Eastern time from the Millennium Broadway Hotel ... A live webcast of the presentation can be accessed at ...
(Date:9/18/2014)... Oncothyreon Inc. (NASDAQ: ONTY ) today announced ... offerings of 10,000,000 shares of its Common Stock at ... for expected gross proceeds of $20 million and 10,000 ... a price to the public of $2,000.00 per share, ... of Series A Convertible Preferred Stock is non-voting and ...
(Date:9/18/2014)... , Sept. 18, 2014   Sigma-Aldrich ... today it has entered into a new gene ... Medical School,s Vector Core. Under the partnership, Sigma-Aldrich ... technology, experimental design consultation, and dedicated gene editing ... accelerate gene editing-based research at the U-M Medical ...
(Date:9/18/2014)... September 18, 2014 SeqLL Inc., ... (tSMS™) technology, announced today the closing of a ... led by Genomic Diagnostic Technologies, will increase the ... applications. , Founded in March 2013 by Daniel ... Analyst at Helicos BioSciences, SeqLL has continued to ...
Breaking Biology Technology:MEI Pharma To Present At BioCentury's NewsMakers Conference 2MEI Pharma To Present At BioCentury's NewsMakers Conference 3Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 2Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 4SeqLL Closes Series-A Funding Round for Expansion of Single Molecule Sequencing 2
... toward large-scale production -SWIFTWATER, Pa. and LYON, France, May ... sanofi-aventis Group (EURONEXT: SAN and NYSE: SNY ... A(H1N1) seed virus, enabling the world,s leading manufacturer of ... A(H1N1) vaccine. The emergence of a new influenza A(H1N1) ...
... CA, May 27, 2009 Senomyx, Inc. (Nasdaq: ... proprietary technologies to discover and develop novel flavor ingredients ... today the appointment of David L. Linemeyer, Ph.D., to ... than 20 years of experience in directing biology research ...
... atherosclerosis vaccine,development program by AFFiRiS AG is receiving ... project is being carried out in,cooperation with German ... is to increase the amount of "good" high ... reduce the occurrence of,harmful fatty deposits in the ...
Cached Biology Technology:Sanofi Pasteur Receives Seed Virus to Produce New Influenza A(H1N1) Vaccine 2Sanofi Pasteur Receives Seed Virus to Produce New Influenza A(H1N1) Vaccine 3SENOMYX ANNOUNCES APPOINTMENT OF DAVID L. LINEMEYER, PH.D., AS VICE PRESIDENT, BIOLOGY 2SENOMYX ANNOUNCES APPOINTMENT OF DAVID L. LINEMEYER, PH.D., AS VICE PRESIDENT, BIOLOGY 3AFFiRiS AG: Atherosclerosis Vaccine Development Receives EU Support 2AFFiRiS AG: Atherosclerosis Vaccine Development Receives EU Support 3