Navigation Links
TGen and ASU researchers find drug that could reduce risk of Alzheimer's
Date:2/2/2009

PHOENIX, Ariz. Feb. 2, 2009 A drug used to improve blood flow to the brain also could help improve learning and memory and reduce the risk of Alzheimer's disease, according to a new study released today by investigators at the Translational Genomics Research Institute (TGen) and Arizona State University.

Fasudil has been used for more than 10 years to help protect the brain in stroke patients by dilating blood vessels when blood flow is curtailed.

Now, a team of Arizona psychologists, geneticists and neuroscientists report in today's edition of the journal Behavioral Neuroscience that hydroxyfasudil, the active form of the parent drug Fasudil, improved spatial learning and working memory in middle-aged rats when negotiating a complicated maze.

The findings suggest that hydroxyfasudil may influence similar cognitive processes in humans involving the hippocampus, a part of the brain that has been shown to deteriorate in patients with age-related disorders.

"If Fasudil proves to be safe and effective in enhancing learning and memory, it could represent a viable new option for the prophylactic treatment of disorders with a cognitive decline component. This could include diseases like Alzheimer's as well as general age-related impairment. In short, it may be a new pharmaceutical weapon that could be used even before the occurrence of symptoms," said Dr. Matthew Huentelman, an Investigator in TGen's Neurogenomics Division.

Clinical trials are being explored in the areas of cognitive impairment and dementia, said Huentelman, the scientific paper's first author.

Although far from proving anything about human use of the drug, the findings supports the scientific quest for a substance that could treat progressive cognitive impairment, cushion the impact of aging, or even enhance learning and memory throughout one's life span.

"Fasudil shows great promise as a cognitive enhancer during aging,'' said
'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. LSUSHC researchers find potential new target for hypertension treatment
2. UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
3. What we don’t know still hurts us, environmental researchers warn
4. Researchers unzip molecules to measure interactions keeping DNA packed in cells
5. Researchers may have found why women have an edge on salt-sensitive hypertension
6. Researchers identify new function of protein in cellular respiration
7. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
8. Researchers identify a cell type that limits stroke damage
9. Researchers iron out new role for serotonin
10. Researchers identify 4 genetic hotspots associated with psoriasis
11. Researchers genetically link Lou Gehrigs disease in humans to dog disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... NEW YORK , April 14, 2015 /PRNewswire/ ... Fast IDentity Online (FIDO ® ) Alliance tm ... standards-based specifications. FIDO members commit to share technology ... authentication methods that are interoperable, more secure and ... specifications enable biometric identity verification that protects sensitive ...
(Date:4/13/2015)... April 13, 2015  higi, a leading cloud-based consumer ... more fully engage with their communities around health and ... protected and secure API.  ... most accessible, affordable, and convenient vehicle to receive validated ... The API will allow higi,s trusted ...
(Date:4/8/2015)... , April 8, 2015  Infinisource, a ... and services, and Morpho, a leading supplier of ... to produce the market,s most advanced biometrically-enabled time ... iSolved NXG time clock is setting a bold, ... labor data for the small and mid-size employer. ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... abuzz after using fruit flies to find new ways ... cellsresults that could one day be used to advance ... that caffeine interferes with processes in cancer cells that ... in using the stimulant as a chemotherapy treatment. But ...
... fish, with an intriguing past, now has had its ... genetic changes that accompanied the adaptation from an aquatic ... by Chris Amemiya, PhD, Director of Molecular Genetics at ... Professor of Biology at the University of Washington, will ...
... to ward off viruses by activating a naturally occurring protein ... disrupts the levels of cholesterol required in cell membranes to ... in molecular microbiology and immunology at the Keck School of ... to fight a variety of viral infections. "Previous studies ...
Cached Biology News:Genome sequencing of the living coelacanth sheds light on the evolution of land vertebrate 2Genome sequencing of the living coelacanth sheds light on the evolution of land vertebrate 3University of Southern California scientists reveal natural process that blocks viruses 2
(Date:5/21/2015)... Specialty Pharmacy Times has completed its ... BPA Worldwide as a business publication member. As ... for Specialty Pharmacy Times based on business/distribution, demographics ... member of BPA Worldwide, Specialty Pharmacy Times shows ... the most reliable, unequaled data,” said Chris Hennessy, ...
(Date:5/21/2015)... 21, 2015 Imagine being able ... and those of others. Being able to read faces ... read people to anticipate their thoughts and actions like ... and feelings to create unique abstract paintings and video, ... Get inside a first-person-shooter as it creates action, dialog, ...
(Date:5/21/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/84975r/2015_global ) ... Global Survey on Flow Cytometry Adoption Trends" ... goal of this research is to analyze the ... information the survey seeks to collect include factors ... used applications for flow cytometers, respondents, most preferred ...
(Date:5/20/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/x4b7kw/top_technologies ... Technologies in HW_Technical Insights" report to their offering. ... technology trends in the Health and Wellness sector and ... have an impact in the year 2015. The research ... 10 health and wellness technologies that are anticipated to ...
Breaking Biology Technology:Specialty Pharmacy Times Joins BPA Worldwide 25 Days to Meet ARGUS - The World's First Contactless Emotions Scanner 2Global Survey on Flow Cytometry Adoption Trends 2015 2Top Technologies in the Health and Wellness Industry 2015 2
... and Preclinical-Stage Compounds ... in Merck KGaA ... drug discovery and development company, announced today that,it will collaborate ... discover new applications for drug candidates. KineMed,s,proprietary pathway-based drug discovery ...
... CHELMSFORD, Mass., Aug. 28 Magellan Biosciences, ... that,Steven E. Diamond, PhD, has joined the ... to Magellan from Siemens Medical Solutions Diagnostics,(formerly ... research and,development, for the point-of-care product lines: ...
... Laboratories, a national,clinical and anatomic pathology reference laboratory ... announced today that it has,renewed a multisource group ... the nation,s largest purchasing alliances of leading,hospitals and ... between ARUP and Premier which has been in ...
Cached Biology Technology:KineMed to Collaborate With Merck KgaA to Validate New Applications for Drug Development Candidates 2Magellan Biosciences Names Steven E. Diamond, PhD, Chief Scientific Officer 2Magellan Biosciences Names Steven E. Diamond, PhD, Chief Scientific Officer 3ARUP Laboratories and Premier Extend Contract for Reference Laboratory Testing Services 2
MOUSE ANTI GUINEA PIG T-CELLS (PAN):FITC Immunogen: Guinea pig peritoneal T-cells...
MOUSE ANTI RABBIT T LYMPHOCTYES Immunogen: Rabbit Thymocytes...
Normal canine serum collected from healthy normal canines....
RABBIT ANTI HUMAN CYTOCHROME P450 1A1/2 Immunogen: Purified human CYP1A2 expressed in E.Coli ...
Biology Products: