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TGen-Scottsdale Healthcare researchers make breakthrough in lung cancer
Date:1/13/2010

SCOTTSDALE, Ariz. Jan. 13, 2010 Researchers for TGen Clinical Research Services at Scottsdale Healthcare (TCRS) have identified a way to predict which patients with small-cell lung cancer may be resistant to first-line chemotherapy.

The study, Tumor MicroRNA Biomarkers Associated with De Novo Chemoresistance in Small Cell Lung Cancer, will be presented today in San Diego at a joint conference of the American Association for Cancer Research (AACR) and the International Association for the Study of Lung Cancer (IASLC).

This breakthrough is critical since patients with small-cell lung cancer (SCLC) often do not get a second chance at therapies to combat this aggressive type of cancer.

"For patients with small cell lung cancer, there are really only about two chemotherapy options. We need to be more precise with our treatments and identify who is going to be resistant up front in order to design better clinical trials that will identify effective therapies for these at-risk patients," said Dr. Glen J. Weiss, director of Thoracic Oncology at TCRS, who presented the findings at AACR-IASLC's Joint Conference on Molecular Origins of Lung Cancer.

TCRS is a partnership between the Translational Genomics Research Institute (TGen) and Scottsdale Healthcare that enables laboratory discoveries to be quickly turned into targeted therapies that can be tested with patients at the Virginia G. Piper Cancer Center in Scottsdale.

Of the nearly 32,000 new cases of SCLC diagnosed in the U.S. every year, between 15 and 30 percent will be chemoresistant to first-line therapy, or about 6,500 SCLC patients annually. SCLC tends to spread much more quickly than non-small cell lung cancer. There are three types of SCLC: small cell carcinoma (oat cell cancer), mixed small cell/large cell carcinoma, and combined small cell carcinoma.

The study led by Dr. Weiss proposed to look at how to best identify those SCLC patients who would be che
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Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

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