Navigation Links
TGen Clinical Research Services at Scottsdale Healthcare and Mayo Clinic study new cancer drug
Date:1/29/2009

ty of solid tumors. It is believed that hypoxia may severely limit the curability of tumors.

TH-302 is converted selectively in the presence of hypoxia to the drug's active form, bromo-isophosphoramide mustard, a potent DNA alkylator. TH-302 targets levels of hypoxia that are common in tumors but are rare in normal tissues this is how selective targeting of the tumor occurs. After conversion to the active form of the drug, the more resistant hypoxic cells are exposed to high concentrations of released cytotoxic agent, which can also diffuse into the oxygenated regions of a tumor cell.

The Phase 1/2 trials are investigating the safety and activity of TH-302 in combination with a number of conventional chemotherapies that are believed to be effective in the non-hypoxic regions of solid tumors.


'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. 3 new informatics pilot projects to aid clinical and translational scientists nationwide
2. Genome Medicine: Bridging the gap between research and clinical practice
3. Far-reaching genetics topics to be addressed: 2009 Annual Clinical Genetics Meeting, March 25-29
4. In just 5 years, gene discovery to clinical trial of potential treatment
5. New book helps medical students master clinical skills
6. Biochemistry of human physiology in health and disease is focus of updated clinical text
7. Self-assembling nano-fiber gel delivers high concentrations of clinically approved drugs
8. A new journal where molecular biology meets clinical research
9. Prosthetic vein valve designed to direct blood flow shows promising pre-clinical results
10. Clinical trial for new tuberculosis vaccine
11. JDRF-funded clinical trial demonstrates continuous glucose monitoring improves blood sugar control
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... stress and stress-related psychiatric disorders are associated ... the molecular mechanisms underlying this relation are ... the development of targeted preventive strategies and ... diseases. This work is presented at the ... Now an international group of researchers from ...
(Date:10/17/2014)... news release is available in German . ... millions of sperms every day in order to reproduce? And ... are the topic of the latest issue of the research ... 2014). The evolutionary biologist Steven Ramm from Bielefeld University Bielefeld ... it is not unusual for a female to copulate with ...
(Date:10/16/2014)... William and Mary,s Virginia Institute of Marine Science ... Environmental Protection Agency to identify the streams and ... develop tools to help local governments and citizens ... critically on a dataset of tidal-marsh observations first ... with this historical baseline can today,s researchers accurately ...
Breaking Biology News(10 mins):Researchers find why depression and aging linked to increased disease risk 2Sperm wars 2EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3
... use of an automated, underwater cell analyzer developed at ... managers were recently able to detect a bloom of ... prevent human consumption of tainted shellfish. Shellfish beds in ... though they are expected to re-open in the next ...
... This research work is the first step to confirm ... to detect the signs of the Climatic Change through the temperatures ... of Applied Physics of the University of Granada ... maximum and minimum temperature series of every month since the end ...
... FAIRBANKS, AlaskaDuring the mid-1970s, Glenn Shaw of the Geophysical ... the notion of Arctic haze after collecting aerosol samples ... Arctic to contain relatively pure air due to its ... rocked once Shaws data indicated there was a murky ...
Cached Biology News:Underwater microscope helps prevent shellfish poisoning along Gulf Coast of Texas 2Underwater microscope helps prevent shellfish poisoning along Gulf Coast of Texas 3Scientists compiled 20th century temperature data in Spain as evidence of climatic change 2Atmospheric scientists gear up for collaborative airborne campaigns 2
(Date:10/22/2014)... The North American crystal oscillator market report defines and ... forecast of revenue. This market was valued at $531.4 ... million by 2018, at a CAGR of 3.3% from ... the North American crystal oscillator market report, to get ... provides a glimpse of the segmentation of the market, ...
(Date:10/22/2014)... 22, 2014 Involution Studios , ... of a new infographic, Understanding Ebola . ... beautifully designed, easy to follow informative tool for anyone ... outbreak, symptoms and prevention. , "As the news has ... 2014 Ebola outbreak represents not only a healthcare crisis ...
(Date:10/22/2014)... Diego, CA (PRWEB) October 22, 2014 ... balances from Sartorius, A & D Weighing, Rice ... Sartorius CPA Semi-Micro Balance . The Sartorius CPA ... for an affordable high-quality, precise, and user-friendly laboratory ... manufacturing of laboratory equipment, their laboratory balances are ...
(Date:10/22/2014)... 2014 Physicians Choice Laboratory Services ... menu, which enables healthcare providers to individualize therapeutic ... evidence-based results, healthcare providers are better able to ... while minimizing risks for adverse drug reactions and ... the FDA [1] more than 2.2 million adverse ...
Breaking Biology Technology:The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 2The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 3The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 4Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 3
Canine Serum...
NORMAL DONOR DONKEY SERUM...
Homo sapiens toll interacting protein Antigen: Recombinant Protein...
Mouse monoclonal [PRMT5-21] to PRMT5 ( Abpromise for all tested applications). entrezGeneID: 10419 SwissProtID: O14744...
Biology Products: