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TGen Clinical Research Services at Scottsdale Healthcare and Mayo Clinic study new cancer drug
Date:1/29/2009

ty of solid tumors. It is believed that hypoxia may severely limit the curability of tumors.

TH-302 is converted selectively in the presence of hypoxia to the drug's active form, bromo-isophosphoramide mustard, a potent DNA alkylator. TH-302 targets levels of hypoxia that are common in tumors but are rare in normal tissues this is how selective targeting of the tumor occurs. After conversion to the active form of the drug, the more resistant hypoxic cells are exposed to high concentrations of released cytotoxic agent, which can also diffuse into the oxygenated regions of a tumor cell.

The Phase 1/2 trials are investigating the safety and activity of TH-302 in combination with a number of conventional chemotherapies that are believed to be effective in the non-hypoxic regions of solid tumors.


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Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

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