Navigation Links
TGen Clinical Research Services at Scottsdale Healthcare and Mayo Clinic study new cancer drug
Date:1/29/2009

SCOTTSDALE, Ariz. Jan. 29, 2008 TGen Clinical Research Services (TCRS) at Scottsdale Healthcare and Mayo Clinic are testing a new drug that may offer broad potential to treat solid tumors.

Clinical trials of the drug TH-302 are being conducted at TGen Clinical Research Services at Scottsdale Healthcare, a partnership of the Phoenix-based Translational Genomics Research Institute (TGen) and Scottsdale-based Scottsdale Healthcare Corp., and at Mayo Clinic in Arizona.

Dr. Glen Weiss, Director of Thoracic Oncology at TCRS at Scottsdale Healthcare, said the new drug appears promising and may be more effective and less toxic to healthy tissues than conventional drugs.

"TH-302 is a new, novel, small molecule that is activated under a metabolic condition characteristic of cancer cells hypoxia (lack of oxygen). The drug candidate may provide an opportunity to treat slowly dividing tumor cells within hypoxic regions that generally evade traditional chemotherapeutic agents and ultimately contribute to relapse," Dr. Weiss said.

Phase 1 and Phase 1/2 trials are underway to investigate the safety and activity of TH-302 in patients with advanced solid tumors. After evidence of tumor activity was observed in the Phase 1 trial in patients with advanced melanoma both non-small cell lung cancer and small cell lung cancer the study was expanded to further investigate TH-302 anti-tumor activity in these tumors. Both Phase 1 and 1/2 trials continue to enroll patients with other solid tumors. If successful, Phase 2 and 3 clinical trials will confirm the drug's effectiveness on solid tumors.

In cancer, as a tumor grows, it rapidly outgrows its blood supply, leaving portions of the tumor with regions where the oxygen concentration is significantly lower than in healthy tissues. This condition is called tumor hypoxia. Several studies have shown that higher levels of tumor hypoxia correlate with poor treatment outcomes for a varie
'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. 3 new informatics pilot projects to aid clinical and translational scientists nationwide
2. Genome Medicine: Bridging the gap between research and clinical practice
3. Far-reaching genetics topics to be addressed: 2009 Annual Clinical Genetics Meeting, March 25-29
4. In just 5 years, gene discovery to clinical trial of potential treatment
5. New book helps medical students master clinical skills
6. Biochemistry of human physiology in health and disease is focus of updated clinical text
7. Self-assembling nano-fiber gel delivers high concentrations of clinically approved drugs
8. A new journal where molecular biology meets clinical research
9. Prosthetic vein valve designed to direct blood flow shows promising pre-clinical results
10. Clinical trial for new tuberculosis vaccine
11. JDRF-funded clinical trial demonstrates continuous glucose monitoring improves blood sugar control
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Dec. 22, 2014 Research and Markets ... the addition of the "The Global ... their offering. ... an overview of the global digital media ... control and monitor piracy by securely and ...
(Date:12/19/2014)... Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ... "iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... July 2012, Apple introduced the fingerprint reading feature ... only device of Apple incorporating such a feature, ...
(Date:12/19/2014)... Dec. 18, 2014  23andMe, Inc., the leading personal ... that pinpoints fine-scale differences in genetic ancestry of individuals ... Since immigrants first arrived more than four ... has served as a meeting place for peoples ... and the ongoing mixing of peoples with African, European, ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 2iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... Ann Liebert, Inc. is pleased to announce significant growth ... Impact Factors published by Thomson Reuters. More than half ... the majority achieving an increase of 10% and higher. ... editorial standards for exceptional quality, supported by outstanding review ...
... Smithsonian Conservation Biology Institute and George Mason University ... complex that embodies the concept of the living ... Studies Program has trained future conservationists with an ... Smithsonian National Zoological Park,s 3,200-acre facility in Front ...
... YORK, N.Y. (June 30, 2011) Autism Speaks Weatherstone Pre-Doctoral ... a 2010 fellow, recently published new findings in the journal ... autism. Their research is based on a mouse model that ... to be associated with autism spectrum disorder (ASD), known as ...
Cached Biology News:Smithsonian Conservation Biology Institute and George Mason University expand partnership 2Weatherstone Fellows publish research as Autism Speaks announces 2011 Weatherstone Fellows 2Weatherstone Fellows publish research as Autism Speaks announces 2011 Weatherstone Fellows 3
(Date:12/24/2014)... December 23, 2014 “Preparative & ... HPLC, Flash), Consumables (Columns, Solvents, Buffers, Valves, Guages, ... & Agriculture) - Forecasts to 2019” provides a ... opportunities, current market trends, and strategies impacting the ... estimates and forecasts of the revenue and share ...
(Date:12/24/2014)... York (PRWEB) December 23, 2014 According to ... Long Island Affiliate of ITRA Global, the national office market ... steady recovery. This is evidenced by the third quarter’s ... stock market. Low energy costs have held inflation down ... only negative is the housing market remaining soft. , This ...
(Date:12/24/2014)... BEIJING , Dec. 23, 2014 ... or the "Company"), a leading fully integrated plasma-based ... today announced that its majority-owned subsidiary, Shandong Taibang ... Practices ("GMP") certification from the China Food and ... factor production facility. As previously disclosed in the ...
(Date:12/24/2014)... NEW YORK , Dec. 23, 2014  NeuroLifeSciences ... of mazindol in children with attention deficit/hyperactivity disorder published ... 2014 . The paper, titled "Pilot ... deficit/hyperactivity disorder" ( Konofal et al, Drug ... 2014 ) shows that mazindol might be an ...
Breaking Biology Technology:Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3
... Milwaukee-based provider of financial technology solutions selected Opsware ... operations Tuesday. Metavante plans to use Opsware to automate ... center information technology environment. , ,We selected Opsware ... complexity and cost in the data center, said Brian ...
... and be more responsive to the needs of their ... they provide as a result of two new products ... company. API Software announced Tuesday the availability of the ... scheduling application, which recently acquired two new contracts. ...
... Third Wave Technologies Inc. , a Madison-based provider of ... 2003 last Tuesday. The year was transitional for Third ... financial resources away from the genomic tools market and ... revenue of $36.3 million and a net loss of ...
Cached Biology Technology:API Releases New Software, Acquires Additional Contracts 2
... Neogens enzyme-linked immunosorbent assay (ELISA) test ... screening devices for the detection of drugs ... kits are intended for forensic use only. ... be confirmed by a quantitative method such ...
Cag-A (IgG) -Ab EIA Sample Size: 10 l...
... pending) is a protein based inhibitor of ... the most common and troublesome RNases including ... SUPERaseIn can be used in any application ... is ideal for in vitro transcription and ...
... Inhibitor is a recombinant human protein produced in ... neutral pancreatic RNase A type enzymes. The ... binds RNases in a 1:1 ratio. The enzyme ... many tissues and cell types. Addition of the ...
Biology Products: