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TGen, Barrow and PCH receive $4 million grant to study genetic basis of brain injuries
Date:12/4/2013

the 10 days following such ruptures, blood vessels can narrow, leading to loss of oxygen, strokes and brain damage.

"If we knew what is happening during this period, we might be able to intervene and prevent the secondary injury," Dr. Kalani said.

Barrow will provide patient care and collect blood and spinal fluid samples that will be analyzed by TGen. A recent TGen study showed spinal fluid could be sequenced for RNA biomarkers. Samples will be checked daily to compare and identify changes.

Another part of the study will be conducted at Barrow's partnership with Phoenix Children's Hospital, where researchers will investigate the effects of intraventricular hemorrhage another form of bleeding in the brain in newborn babies. Intraventricular hemorrhage in newborns occurs secondary to diminished blood flow and oxygen delivery to the brain. Intraventricular hemorrhage is associated with the development of hydrocephalus and damage to the brain that can result in cerebral palsy or other types of motor and cognitive delays.

"This study will get us one step closer to learning what is unique in pediatric stroke so we can provide the best quality care and improve the long term outcomes for these children," said Dr. P. David Adelson, one of the principal investigators of the study at Barrow Neurological Institute at Phoenix Children's Hospital.

"In addition, as this study progresses, we want to know how to identify children at risk, and how they differ from adults with similar conditions, this will not only help us to be more accurate at providing current treatments but to develop new ones." said Dr. Jorge Arango, an investigator affiliated with Barrow Neurological Institute at Phoenix Children's Hospital and with the University of Arizona College of Medicine-Phoenix.

In the study of both adults and children, TGen researchers will use state-of-the-art sequencing to analyze RNA transcripts, searching for biomarkers th
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Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

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