Navigation Links
'TF beacons' may light path to new cancer tests and drugs
Date:9/7/2011

Scientists are reporting development of a long-sought new way to detect the activity of proteins that bind to the DNA in genes, often controlling the activity of genes in ways that make cells do everything from growing normally to becoming cancerous. Their report appears in the Journal of the American Chemical Society.

Kevin Plaxco, Francesco Ricci and colleagues note that more than 10 percent of the 25,000-30,000 genes in the human body contain instructions for manufacturing these so-called DNA-binding proteins. Most of these proteins are master regulators called transcription factors (TFs). They start or stop the first step in the process in which gene's instructions are put into action. TFs bind to DNA and turn genes on or off. Understanding and measuring the activity of TFs is important because they are involved in health and disease, with many linked to cancers, for instance. With existing ways of detecting the activity of TFs being slow and cumbersome, the scientists set out to overcome that barrier.

The scientists describe development and successful tests of fluorescent sensors that they term "transcription factor beacons." The beacons signal the activity and concentration of TFs directly in biological samples by switching from a dark state to a fluorescent state upon binding to their specific TF. Using TF Beacons is simpler and works faster than current methods, and the scientists say TF beacons may have multiple uses in diagnosing cancer, searching for new cancer drugs and other areas.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers use nanoparticles as destructive beacons to zap tumors
2. Highlights of upcoming conference on aldosterone & the ENaC/Degenerin family of ion channels
3. Up from the depths: How bacteria capture carbon in the twilight zone
4. Weight loss without the hunger: Cornell scientists say eat a lighter lunch
5. The genome of mesopolyploid crop Brassica rapa sheds new light on the study of genome evolution
6. New imaging method sheds light on cell growth
7. New theory may shed light on dynamics of large-polymer liquids
8. Small molecules shed light on cancer therapies
9. Study sheds light on late phase of asthma attacks
10. Scientists highlight link between stress and appetite
11. The flight of the bumble bee: Why are they disappearing?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... April 11, 2017 Crossmatch®, a globally-recognized ... solutions, today announced that it has been awarded ... Projects Activity (IARPA) to develop next-generation Presentation Attack ... "Innovation has been a driving force within ... will allow us to innovate and develop new ...
(Date:4/5/2017)... -- The Allen Institute for Cell Science today announces the ... and dynamic digital window into the human cell. The ... of deep learning to create predictive models of cell ... growing suite of powerful tools. The Allen Cell Explorer ... available resources created and shared by the Allen Institute ...
(Date:3/30/2017)... -- On April 6-7, 2017, Sequencing.com will host the world,s ... at Microsoft,s headquarters in Redmond, Washington ... health and wellness apps that provide a unique, personalized ... is the first hackathon for personal genomics and the ... the genomics, tech and health industries are sending teams ...
Breaking Biology News(10 mins):
(Date:5/18/2017)... ... May 18, 2017 , ... Dr. Ralph Mobbs ... the Prince Of Wales Private Hospital. The procedure was performed on a 46-year-old ... failed conservative treatments prior to undergoing surgery. , The AxioMed viscoelastic disc is ...
(Date:5/18/2017)... ... ... Clinical Supplies Management (“CSM”), a Great Point Partners II (“GPP”) portfolio company, today ... doubled in size over the past six months with the acquisition of businesses in ... CSM as Chief Financial Officer. Roger has over 25 years of experience in ...
(Date:5/18/2017)... ... May 17, 2017 , ... ... expertise, and further enhances its scientific power by providing investigators access to ... has agreed to join the scientific advisory board. “We are committed to ...
(Date:5/18/2017)... ... May 17, 2017 , ... ... optimization firm for the life sciences and healthcare industries, is honored that ... for Medical Devices conference in Brussels, Belgium. , Crowley played a crucial role ...
Breaking Biology Technology: