Navigation Links
'TF beacons' may light path to new cancer tests and drugs
Date:9/7/2011

Scientists are reporting development of a long-sought new way to detect the activity of proteins that bind to the DNA in genes, often controlling the activity of genes in ways that make cells do everything from growing normally to becoming cancerous. Their report appears in the Journal of the American Chemical Society.

Kevin Plaxco, Francesco Ricci and colleagues note that more than 10 percent of the 25,000-30,000 genes in the human body contain instructions for manufacturing these so-called DNA-binding proteins. Most of these proteins are master regulators called transcription factors (TFs). They start or stop the first step in the process in which gene's instructions are put into action. TFs bind to DNA and turn genes on or off. Understanding and measuring the activity of TFs is important because they are involved in health and disease, with many linked to cancers, for instance. With existing ways of detecting the activity of TFs being slow and cumbersome, the scientists set out to overcome that barrier.

The scientists describe development and successful tests of fluorescent sensors that they term "transcription factor beacons." The beacons signal the activity and concentration of TFs directly in biological samples by switching from a dark state to a fluorescent state upon binding to their specific TF. Using TF Beacons is simpler and works faster than current methods, and the scientists say TF beacons may have multiple uses in diagnosing cancer, searching for new cancer drugs and other areas.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers use nanoparticles as destructive beacons to zap tumors
2. Highlights of upcoming conference on aldosterone & the ENaC/Degenerin family of ion channels
3. Up from the depths: How bacteria capture carbon in the twilight zone
4. Weight loss without the hunger: Cornell scientists say eat a lighter lunch
5. The genome of mesopolyploid crop Brassica rapa sheds new light on the study of genome evolution
6. New imaging method sheds light on cell growth
7. New theory may shed light on dynamics of large-polymer liquids
8. Small molecules shed light on cancer therapies
9. Study sheds light on late phase of asthma attacks
10. Scientists highlight link between stress and appetite
11. The flight of the bumble bee: Why are they disappearing?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... Sweden , April 28, 2016 First ... M (139.9), up 966% compared with the first quarter of 2015 ... profit totaled SEK 589.1 M (loss: 18.8) and the operating margin ... 7.12 (loss: 0.32) Cash flow from operations was SEK ... The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
(Date:4/15/2016)... -- A new partnership announced today will help life ... a fraction of the time it takes today, ... insurance policies to consumers without requiring inconvenient and ... rapid testing (A1C, Cotinine and HIV) and higi,s ... pulse, BMI, and activity data) available at local ...
(Date:3/31/2016)... , March 31, 2016   ... ("LegacyXChange" or the "Company") LegacyXChange is excited ... of its soon to be launched online site for ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders a ... DNA technology to an industry that is notorious for ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ... and Mold) microbial test has received AOAC Research Institute approval 061601. , “This ... introduced last year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking ... Arkansas State Crime Laboratory, has joined STACS DNA as a Field Application Specialist. ... Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding our capacity as ...
(Date:6/23/2016)... 23, 2016 On Wednesday, June 22, ... down 0.22%; the Dow Jones Industrial Average edged 0.27% lower ... 2,085.45, down 0.17%. Stock-Callers.com has initiated coverage on the following ... Therapeutics (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... BIND ). Learn more about these stocks by accessing ...
(Date:6/23/2016)... , June 23, 2016 ... market research report to its pharmaceuticals section with ... product details and much more. Complete ... across 151 pages, profiling 15 companies and supported ... at http://www.reportsnreports.com/reports/601420-global-cell-culture-media-industry-2016-market-research-report.html . The ...
Breaking Biology Technology: