Navigation Links
TESARO and Virginia G. Piper Cancer Center announce first patient in clinical trial of TSR-011
Date:11/1/2012

WALTHAM, Mass. Nov. 1, 2012 TESARO, Inc. (Nasdaq: TSRO) announced today that the first clinical trial of its proprietary Anaplastic Lymphoma Kinase (ALK) inhibitor, TSR-011, has commenced with the dosing of the first patient at the Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare, a partnership between Scottsdale Healthcare and the Translational Genomics Research Institute (TGen).

TSR-011 is an orally available ALK inhibitor (targeted anti-cancer agent) that will be studied in patients, including non-small cell lung cancer (NSCLC) patients, with ALK+ tumors. TESARO plans to expand the Phase 1/2 clinical trial of TSR-011 to multiple clinical trial sites in the U.S. and Europe.

"TSR-011 has the profile of a promising targeted anti-cancer agent and we are enthusiastic about the opportunity to investigate its potential in patients," said Dr. Glen Weiss, Director of Thoracic Oncology at the Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare and Clinical Associate Professor at TGen.

Following identification of the maximum tolerated dose of TSR-011 in patients with advanced cancer during the dose escalation phase of the trial, TESARO plans to evaluate TSR-011 in three parallel cohorts of patients in the phase 2 portion: those with ALK+ NSCLC who have not been previously treated with ALK inhibitors, those with NSCLC who have progressed during treatment with other ALK inhibitors, and those with other tumor types expressing ALK.

"We are very pleased to have progressed TSR-011 into a human clinical trial and look forward to identifying a dose that may be utilized in the expansion phase of the study which will assess both the safety and efficacy of the compound," said Mary Lynne Hedley, Ph.D., TESARO's President and Chief Scientific Officer. "ALK is a key driver of subsets of NSCLC, and may also contribute to the growth of neuroblastoma, lymphoma and other cancers. In order to max
'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Virginia Tech announces 2012 football helmet ratings; 2 more added to the 5-star mark
2. Biology professor secures grant to save West Virginias primary natural history collection
3. Virginia Tech and University of Tuscia lead team to unravel origin of devastating kiwifruit bacterium
4. Scientific meeting at Virginia Tech will make more than $2 million economic impact
5. Old deeds, witness trees offer glimpse of pre-settlement forest in West Virginia
6. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
7. Embryonic development protein active in cancer growth
8. BRG1 mutations confer resistance to hormones in lung cancer
9. Genetic variation in East Asians found to explain resistance to cancer drugs
10. Beyond the microscope: Identifying specific cancers using molecular analysis
11. Marshall University study may lead to new treatments for prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2015)... , July 23, 2015 Research and ... of the "Global Outlook of the Biometrics ... The global biometrics market is ... and commercial applications owing to the uptake of ... a transformation that enhances the growth of biometrics ...
(Date:7/20/2015)...  Acuity Market Intelligence,s latest research "The Global ... and Privacy" forecasts that between 2014 and 2020 ... downloaded to smart mobile devices by 2.2 billion ... projected to generate more than $67.9 billion in ... period.    "Biometrics is at the ...
(Date:7/9/2015)... , July 07, 2015 ... announced the addition of the "Biometrics for ... Forecasts 2015-2020" report to their offering. ... major contributor to this growth and the forecast ... billion in revenue for companies involved in delivering ...
Breaking Biology News(10 mins):Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3
... researcher has been awarded the Best Film of the Year ... computed microtomography recently celebrated in Brussels, Belgium. Professor Javier Alba ... his biofilm titled Micro-CT anatomical study of a female an ... This film shows from the inside the anatomy of a ...
... Biologists (ASPB) is pleased to announce the recipients of its ... Charles Reid Barnes Life Membership Award ... Florida, Gainesville , Established in 1925, the Charles Reid ... service in plant biology. Hanson, this year,s honoree, is recognized ...
... Calif. Entomologists at the University of California, Riverside ... chemical element, can disrupt the foraging behavior and survival ... low concentrations is necessary for the normal development of ... only slightly higher concentrations when it replaces sulfur in ...
Cached Biology News:Spanish researcher releases a video showing a beetle from the inside 2ASPB names 2012 award recipients 2ASPB names 2012 award recipients 3ASPB names 2012 award recipients 4ASPB names 2012 award recipients 5Selenium impacts honey bee behavior and survival 2Selenium impacts honey bee behavior and survival 3
(Date:7/31/2015)... 31, 2015 In today,s fast changing ... them drive positive health outcomes, improve profitability and ... patient care in their communities. At ThoughtSpot 2015, ... conference, AmerisourceBergen announced a new set of innovative ... Organization and help independent pharmacies endure the industry,s ...
(Date:7/31/2015)... 31, 2015 China Cord Blood Corporation (NYSE: ... leading provider of cord blood collection, laboratory testing, ... today announced that the Company has filed its Annual ... Exchange Commission. The filed Form 20-F includes audited financial ... The Form 20-F can be accessed by visiting the ...
(Date:7/30/2015)... , ... July 31, 2015 , ... Ralco is honored ... at the Lyon County Fair to be held August 5-9 in Marshall. The Ralco ... their meals come from and how agriculture impacts their daily lives. This unique exhibit ...
(Date:7/30/2015)...   GenoSpace , a leading provider of ... of genomic and other biomedical data, today announced ... company as Vice President of Sales and Marketing. ... "GenoSpace partners with its customers to ... explore complex sets of genomic, phenotypic and other ...
Breaking Biology Technology:AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 2AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 3China Cord Blood Corporation Files Its Annual Report on Form 20-F 2Ralco Announces Primary Sponsorship of Ralco Enrichment Center at Lyon County Fair 2GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2
... October 23, Rosetta Genomics Ltd. (Nasdaq: ROSG ), ... therapeutics, today,announced that it will present at the ... The event will take place from,October 30 to ... presentation, titled "MicroRNA-based identification of tumor,origin", will describe ...
... FRANCISCO, Calif., Oct. 23 Poniard,Pharmaceuticals, Inc. (Nasdaq: ... today announced that it will hold a conference ... provide a corporate update,including an update on the ... candidate., Jerry McMahon, Ph.D., chairman and chief ...
... NEW YORK and SAN DIEGO, Oct. 23, ... ) and Phenomix Corporation today announced,that they ... to develop,and commercialize dutogliptin (PHX1149) in North ... molecule,dipeptidyl-peptidase-4 (DPP-4) inhibitor currently undergoing Phase 3,clinical ...
Cached Biology Technology:Rosetta Genomics to Present at the Upcoming EORTC-NCI-ASCO Annual Meeting on "Molecular Markers in Cancer" 2Rosetta Genomics to Present at the Upcoming EORTC-NCI-ASCO Annual Meeting on "Molecular Markers in Cancer" 3Poniard Pharmaceuticals to Host Third Quarter 2008 Financial Results Conference Call on October 30 2Phenomix and Forest Laboratories to Collaborate on Development and Commercialization of Dutogliptin in Diabetes 2Phenomix and Forest Laboratories to Collaborate on Development and Commercialization of Dutogliptin in Diabetes 3Phenomix and Forest Laboratories to Collaborate on Development and Commercialization of Dutogliptin in Diabetes 4
... ONE Ribonuclease is a 27kDa periplasmic enzyme ... of RNA to cyclic nucleotide monophosphate (NMP) ... of these intermediates to 3-NMPs (1). RNase ... known RNases that can cleave a phosophodiester ...
... polyclonal to Dideoxycytidine Dideoxycytidine is a cytidine ... in inhibiting retroviral activity. Immunogen: ... Specificity: The specificity of the ddC ... the moles of ddC to moles of ddC ...
Porcine Pulmonary Artery Endothelial Cells (PPAEC) (>500,000 cells)...
... Jouan MSC series of Class II ... conditions and certification to the world's ... ensures that the cabinets cannot be ... Natural lighting, low noise and arm ...
Biology Products: