Navigation Links
TB outbreaks could be 'solved' by DNA tracking
Date:9/3/2012

Reconstructing the spread of killer diseases such as tuberculosis (TB) from person to person using DNA sequencing quickly identifies the origin and movement of pathogens. This approach is directly informing public health strategies to control infectious disease outbreaks, says a scientist speaking at the Society for General Microbiology's Autumn Conference at the University of Warwick.

A team from the British Columbia Centre for Disease Control in Vancouver, Canada used whole-genome sequencing to analyse the bacterial DNA in samples from 36 of 41 infected individuals in a TB outbreak. They were able to track the pathogen's movements through the community in British Columbia, including where it started and who infected whom. From this they could identify key persons, places, and behaviours that contributed to the spread of disease. They showed how the social structure of a community contributed to the rapid spread of TB and that a rise in crack cocaine use in the area may have triggered the outbreak.

Earlier epidemiological tools analysed some - but not all - of the DNA in infected samples. This gave too little information to accurately reconstruct an outbreak and scientists could only make informed guesses at how a pathogen spread through a population. Lead researcher Dr Jennifer Gardy, speaking at the conference said, "'Solving' an outbreak - identifying the source of the disease and the underlying patterns of transmission - is the proverbial holy grail of epidemiology. Using whole-genome sequencing we are now able to act like field naturalists and observe how pathogens behave out in the wild. We can see where outbreaks start and how they spread. This level of insight has never been seen before and it promises to change the way we do public heath outbreak investigations."

The group is currently applying the same reconstruction technique to a different TB outbreak in a different social setting. "We are discovering how important location-based transmission is, and that identifying and screening individuals who visited these locations are integral to outbreak management," explained Dr Gardy. Other research groups are applying this genome-based approach for outbreak reconstruction to other micro-organisms. "We hope to build a 'pathogen knowledge base' that describes how different communicable diseases spread in different social and environmental settings. From this we will be able to identify commonalities that can be targeted in global public health interventions."

The work is directly informing public health policy and practice, said Dr Gardy. "As frontline public health practitioners we are using whole-genome sequencing to answer pressing questions. We are able to take our research findings and translate them into clinical action in the short term. With better control and prevention programmes, we can ultimately reduce the burden of certain infectious diseases," she said.


'/>"/>

Contact: Laura Udakis
l.udakis@sgm.ac.uk
44-079-908-26696
Society for General Microbiology
Source:Eurekalert  

Related biology news :

1. Researchers use game to change how scientists study disease outbreaks
2. Coconut oil could combat tooth decay
3. Chilling methods could change meat tenderness
4. Viruses could be the key to healthy corals
5. Early activation of immune response could lead to better vaccines
6. Computer viruses could take a lesson from showy peacocks
7. Collagen-seeking synthetic protein could lead doctors to tumor locations
8. Climate change could increase levels of avian influenza in wild birds
9. Manipulating the microbiome could help manage weight
10. U of M researchers: Newly discovered genetic markers could signal colon cancer development
11. Farmer-led irrigation schemes could alter food security in sub-Saharan Africa, South Asia
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
TB outbreaks could be 'solved' by DNA tracking
(Date:4/11/2017)... Research and Markets has announced the addition ... their offering. ... tracking market to grow at a CAGR of 30.37% during the ... 2017-2021, has been prepared based on an in-depth market analysis with ... its growth prospects over the coming years. The report also includes ...
(Date:4/11/2017)... , April 11, 2017 NXT-ID, ... security technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate ... ... NXT-ID, we look forward to their guidance and benefiting from ...
(Date:4/5/2017)... SEATTLE , April 5, 2017  The Allen ... the Allen Cell Explorer: a one-of-a-kind portal and dynamic ... large-scale 3D imaging data, the first application of deep ... edited human stem cell lines and a growing suite ... the platform for these and future publicly available resources ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading provider ... nationwide oncology Clinical Nurse Educator (CNE) network, which will launch ... for communication among health care professionals to enhance the patient ... office staff, and other health care professionals to help women ... cancer. ...
(Date:10/11/2017)... TX (PRWEB) , ... October 11, 2017 , ... ... August compared the implantation and pregnancy rates in frozen and fresh in ... contribution of progesterone and maternal age to IVF success. , After comparing the ...
(Date:10/10/2017)... Los Angeles, CA (PRWEB) , ... ... ... Pharmaceuticals, Inc., a development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) ... all uses of targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
Breaking Biology Technology: