Navigation Links
TB-drugome provides new targets for anti-tuberculosis drug discovery
Date:11/8/2010

Researchers at the University of California, San Diego School of Medicine and the University of Leeds have linked hundreds of federally approved drugs to more than 1,000 proteins in Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), opening new avenues to repurpose these drugs to treat TB.

The study was published Nov. 4 in PLoS Computational Biology.

"Tuberculosis is currently one of the most widely spread infectious diseases, with an estimated one-third of the world's population infected and between one and two million people dying each year from the disease," said Philip Bourne, PhD, professor of pharmacology at UCSD's Skaggs School of Pharmacy and Pharmaceutical Sciences. "The continuing emergence of M. tuberculosis strains resistant to all existing, affordable drug treatments requires the development of novel, effective and inexpensive drugs.

The newly developed TB-drugome may help that effort, Bourne said, by identifying new M. tuberculosis protein targets that can be perturbed by a variety of existing drugs prescribed for other purposes.

Sarah Kinnings at the University of Leeds and a team of scientists at UC San Diego, led by Bourne (who is also associate director of the RCSB Protein Data Bank) and research scientist Lei Xie, PhD, used a novel computational strategy to investigate whether any existing drugs were able to bind to any of the approximately 40 percent of proteins in the M. tuberculosis proteome with decipherable three-dimensional structures.

The researchers not only discovered that approximately one-third of the drugs examined may have the potential to be repurposed to treat tuberculosis, but also that many currently unexploited M. tuberculosis proteins could serve as novel anti-tubercular targets. This finding led the investigators to construct a complex network of drug-target interactions a TB-drugome available to all scientists.

While this new computational,
'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study provides treatment hope for long term effects of brain trauma
2. 100-million-year-old mistake provides snapshot of evolution
3. UF research provides new understanding of bizarre extinct mammal
4. Study provides data that can inform Atlantic sturgeon recovery efforts
5. Protein provides link between calcium signaling in excitable and non-excitable cells
6. Going green: New program provides vital support for plant scientists
7. Hair provides proof of the link between chronic stress and heart attack
8. LSUHSC pediatric weight expert provides obesity trinity answers
9. Special edition journal provides new perspectives and guidance for managing white pine blister rust
10. Huntingtons disease discovery provides new hope for treatment
11. De La Rue Provides Second-Generation ePassport for Malta
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... Researchers at UC Davis have made some surprising ... infection. Studying simian immunodeficiency virus (SIV), the team ... Paneth cells are early responders to viral invasion ... producing a cytokine called interleukin-1 beta (IL-1β). ... IL-1β causes breakdown of the gut epithelium that ...
(Date:8/29/2014)... A leading U.S. Ebola researcher from the University of Texas ... a blend of three monoclonal antibodies can completely protect monkeys ... days after infection, at a time when the disease is ... written an editorial for Nature discussing advances in ... Marburg virus are among the most deadly of pathogens, with ...
(Date:8/29/2014)... This news release is available in German . ... are key players in the natural nitrogen cycle on ... these specialist bacteria were thought to depend on nitrite ... scientists led by Holger Daims, a microbiologist at the ... can use hydrogen as an alternative source of energy. ...
Breaking Biology News(10 mins):The early cost of HIV 2Leading Ebola researcher at UTMB says there's an effective treatment for Ebola 2Hydrogen powers important nitrogen-transforming bacteria 2Hydrogen powers important nitrogen-transforming bacteria 3
... 12,000 new animalsmicroscopic Elkhorn coral larvae harvested by ... an international collaborative program to raise the threatened ... return the animals, once they are grown, to ... Reproductive Scientist Dr. Mary Hagedorn and Invertebrates Keeper ...
... RIVERSIDE, Calif. While prescription medications work successfully to cure ... of the same drug can cause an adverse reaction or ... led by Sean Cutler, an assistant professor of plant cell ... be analyzed by studying much simpler organisms like plants. ...
... Institute of Technology has been selected by the New ... in Technology Education Award, in recognition of the Institutes ... technological university. Stevens will be honored by the NJTC ... Science Center in Jersey City, N.J., November 15, 2007. ...
Cached Biology News:Smithsonian scientists working to save microscopic threatened species 2Plants can be used to study how and why people respond differently to drugs 2Stevens wins Excellence in Technology Education Award 2
(Date:9/2/2014)... ROCKVILLE, Md. , Sept. 2, 2014 /PRNewswire/ ... of novel anti-infective biologic and drug candidates targeting ... announced today positive results from its final preclinical ... Drug Administration (FDA) guidance, this bridging study was ... product candidate designed to prevent the devastating effects ...
(Date:9/2/2014)... Victoria, Australia (PRWEB) September 02, 2014 ... provide a cure for chronic tinnitus are seeking support ... run on the Indiegogo platform ( http://igg.me/at/tinaway ), was ... to be a therapeutic ‘mHealth’ app and is based ... brainchild of a team of biomedical and software engineers, ...
(Date:8/31/2014)... 01, 2014 Available spectra is ... for research and cultivation of a wide range ... proprietary LEDs with proven patented and pending wide ... light uniformity in critical applications in contrast to ... , “Our customers have a large variety of ...
(Date:8/29/2014)... circuits are based on electrons, but one of the ... circuits, i.e. circuits based on light (photons) instead of ... create a stream of single photons and control their ... of attempts to achieve this control, but now scientists ... a steady stream of photons emitted one at a ...
Breaking Biology Technology:Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 2Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 3Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 4Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 5tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 2tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 3tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 4tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 5Breakthrough in light sources for new quantum technology 2
... Terrace, Ill. - Browser-based attacks are surging and may pose ... That is one of the key findings of the second ... CompTIA , the Computing Technology Industry Association. , ,The ... plagued by one or more browser-based attacks in the last ...
... Wis. High-speed Internet access is now a reality ... non-line-of-sight wireless broadband system. Toronto-based WaveRider Communications Inc. ... and Oakdale Electric Cooperative to implement ... previously lacked access to broadband Internet services. , ,The ...
... MADISON - University of Wisconsin-Madison faculty and staff interested ... resource to help them through the process of taking ... for New Business Ventures at the University of Wisconsin-Madison," ... Web site of the UW-Madison Office of Corporate Relations ...
Cached Biology Technology:Browser-based attacks may pose next big IT security nightmare 2Rural Wisconsin town gets high-speed Internet access 2New guide offers assistance to UW-Madison entrepreneurs 2
... at its Best: DASGIPs Process Control ... Changes & comprehensive documentation for cultivation ... auch as pH, dissolved oxygen, temperature ... changeable online. Profiles, e.g. constant or ...
... LC Sciences provides a genome-wide microRNA (miRNA) ... proprietary probe design, which enable highly sensitive ... We have standard arrays for mature miRNA ... version of the Sanger miRBase database (Release ...
... acid synthetic peptide whose sequences are derived from mouse resistin protein. ... S(21) - S - M - P - L - C ... I - D - K - K - I - K ... be used for neutralization and control experiments with the polyclonal antibody ...
... 2D Proteomic Imaging System, Basic Package ... Wide Dynamic Range: The ProXPRESS 2D Proteomic ... imaging system for both proteomic and general ... unparalleled flexibility, enabling the use of all ...
Biology Products: