Navigation Links
TB-drugome provides new targets for anti-tuberculosis drug discovery
Date:11/8/2010

Researchers at the University of California, San Diego School of Medicine and the University of Leeds have linked hundreds of federally approved drugs to more than 1,000 proteins in Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), opening new avenues to repurpose these drugs to treat TB.

The study was published Nov. 4 in PLoS Computational Biology.

"Tuberculosis is currently one of the most widely spread infectious diseases, with an estimated one-third of the world's population infected and between one and two million people dying each year from the disease," said Philip Bourne, PhD, professor of pharmacology at UCSD's Skaggs School of Pharmacy and Pharmaceutical Sciences. "The continuing emergence of M. tuberculosis strains resistant to all existing, affordable drug treatments requires the development of novel, effective and inexpensive drugs.

The newly developed TB-drugome may help that effort, Bourne said, by identifying new M. tuberculosis protein targets that can be perturbed by a variety of existing drugs prescribed for other purposes.

Sarah Kinnings at the University of Leeds and a team of scientists at UC San Diego, led by Bourne (who is also associate director of the RCSB Protein Data Bank) and research scientist Lei Xie, PhD, used a novel computational strategy to investigate whether any existing drugs were able to bind to any of the approximately 40 percent of proteins in the M. tuberculosis proteome with decipherable three-dimensional structures.

The researchers not only discovered that approximately one-third of the drugs examined may have the potential to be repurposed to treat tuberculosis, but also that many currently unexploited M. tuberculosis proteins could serve as novel anti-tubercular targets. This finding led the investigators to construct a complex network of drug-target interactions a TB-drugome available to all scientists.

While this new computational,
'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study provides treatment hope for long term effects of brain trauma
2. 100-million-year-old mistake provides snapshot of evolution
3. UF research provides new understanding of bizarre extinct mammal
4. Study provides data that can inform Atlantic sturgeon recovery efforts
5. Protein provides link between calcium signaling in excitable and non-excitable cells
6. Going green: New program provides vital support for plant scientists
7. Hair provides proof of the link between chronic stress and heart attack
8. LSUHSC pediatric weight expert provides obesity trinity answers
9. Special edition journal provides new perspectives and guidance for managing white pine blister rust
10. Huntingtons disease discovery provides new hope for treatment
11. De La Rue Provides Second-Generation ePassport for Malta
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... SM announced today its completion of a Good ... current U.S. Food and Drug Administration (FDA) regulations. This ... smart phone application trials utilizing the highest principles for ... determined to improve global healthcare access, quality, and delivery ...
(Date:12/15/2014)... 12, 2014 Research and Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ... Facial Recognition Market 2015-2019" report to their offering. ... Facial recognition is a technology used for the identification ... feature of a person such as nose, jaw edges, ...
(Date:12/11/2014)... Minn. , Dec. 10, 2014  Data Sciences ... monitoring, has released a new series of digital ... preclinical toxicology researchers. M series, part of the ... collect the best possible physiologic data when incorporating ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3New telemetry implants expected to change how large animal toxicology studies are conducted 2
... a team led by researchers from Caltech has for ... of chemoreceptorsthe receptors that sense and respond to chemical ... specific architecture is the same throughout a wide variety ... stable, universal structure that has been conserved over evolutionary ...
... new university/industry network to pursue the development of biomaterials, ... increasing incidence of eye disease. The 20/20: NSERC ... as part of the Natural Sciences and Engineering Research ... Minister of State (Science and Technology) Gary Goodyear today ...
... cell researcher Treena Livingston Arinzeh will discuss current stem cell ... for bone fracture and osteoarthritis treatments, spinal cord repair, and ... The event will be held Sept. 29, 2009, at ... floor of the NJIT Campus Center. The ...
Cached Biology News:Caltech scientists get detailed glimpse of chemoreceptor architecture in bacterial cells 2Caltech scientists get detailed glimpse of chemoreceptor architecture in bacterial cells 3Caltech scientists get detailed glimpse of chemoreceptor architecture in bacterial cells 4New research network at McMaster aims to build a better eye 2
(Date:1/22/2015)... San Diego, California (PRWEB) January 22, 2015 ... R Promotional Offer to their comprehensive portfolio of ... Offer allows customers to purchase a Centrifuge 5424/5424 R ... Pipette Bundle of either Eppendorf Research plus or Eppendorf ...
(Date:1/22/2015)... Controlled Substance Compliance Services (CSCS), a project ... the legal requirements around using controlled substances in pharmaceutical ... As their international operations expand and become increasingly complex, ... as a result of the first phase of the ...
(Date:1/22/2015)... 22 de enero de 2015  El Dr. Paul ... llamada a nominaciones para 2015. Este prestigioso premio reconoce ... tiene el potencial para hacer, contribuciones destacadas para la ... hasta el 15 de marzo de 2015 a través ...
(Date:1/22/2015)... 2015   GenoSpace , a precision medicine software company that ... broad use of genomic, imaging and other biomedical data in ... Michelle Munson , CEO of Aspera, an IBM Company, to ... http://photos.prnewswire.com/prnh/20150122/170713 "We are pleased to ...
Breaking Biology Technology:Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Global Compliance Service for Controlled Substances to Expand to China 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4GenoSpace Expands Board with Appointment of Michelle Munson 2
... Wis. - Judy Faulkner, founder and CEO of Epic ... monthly meeting held at the Promega BTC Center. The audience ... of this unique, and successful company. , ,For over twenty ... association events. She does not participate on outside company boards ...
... - KLAS Enterprises, a research and consulting firm ,based ... Vendor in its Top 20 Year-end Report Card. The ... confidential survey of CIOs, executives, managers, and clinicians representing ... and reporting the performance of healthcare's information technology (HIT) ...
... conference and stayed at a hotel, which promoted wireless Internet ... implemented it so only those on the first floor could ... wireless Internet service when Im at seminars because I usually ... Out of curiosity, on my second night at the hotel ...
Cached Biology Technology:Epic's Founder Judy Faulkner Speaks on Culture, Business Beliefs, and Recruiting: WTN Exclusive Coverage 2Epic's Founder Judy Faulkner Speaks on Culture, Business Beliefs, and Recruiting: WTN Exclusive Coverage 3Wireless Are you at Risk and Liable? 2Wireless Are you at Risk and Liable? 3Wireless Are you at Risk and Liable? 4
KV beta.1 (Q-13)...
Preadipocyte factor-1 [Pref-1, DLK-1], C-terminal...
... PGE2-d4 contains 4 deuterium atoms at ... It is intended for use as an ... E2 (PGE2) by GC- or LC-mass spectrometry. ... products of arachidonic acid and one of ...
Deletions, insertions or substitutions. Mutations in plasmids of size up to 15 kb. Single or multiple mutations...
Biology Products: