Navigation Links
TB bacterium uses its sugar coat to sweeten its chances of living in lungs
Date:9/29/2008

COLUMBUS, Ohio Common strains of tuberculosis-causing bacteria have hijacked the human body's immune response to play tricks on cells in the lungs, scientists say.

The results of this takeover are mixed. The cells essentially welcome the bacteria into the lungs and invite them to stay a while, meaning the human host becomes infected with the TB bacterium. But in about 90 percent of these cases, the infection remains latent and the infected person never has any symptoms of illness.

The secret weapon in this stealth attack is sugar.

Ohio State University researchers have determined that Mycobacterium tuberculosis has learned through evolution to coat itself with a sugar called mannose, which makes the bacterium attractive to cells in the lungs that are looking to clean up and discard unwanted sugar in the body. Those lung cells absorb the TB bacteria, giving the infecting bacteria a place to live for the long term.

"The bug sugarcoats itself and creates this magical interaction that allows it to slip by the immune system. We think that this is a beautiful example of the concept of host adaptation," said Larry Schlesinger, professor of internal medicine and director of the division of infectious diseases at Ohio State. "TB has evolved in humans. We're the reservoir. It has had centuries to develop a sophisticated way to deal with its encounter with the human, and the lung is the special portal of entry."

Schlesinger, also director of Ohio State's Center for Microbial Interface Biology, reported on TB's adaptation to the human respiratory system Friday (9/26) at the First International Congress "Mycobacteria: A Challenge for the 21st Century" in Bogot, Colombia.

Part of his presentation in Colombia touched on the most recent discovery in his lab two strains of TB bacteria that do not show these signs of adaptation. The existence of these other strains suggests that some strains of TB bacteria can be t
'/>"/>

Contact: Larry Schlesinger
larry.schlesinger@osumc.edu
614-292-8789
Ohio State University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Cyanobacterium sequenced features rare linear chromosome
2. UCR graduate student discovers, names bacterium linked to psyllid yellows
3. Single-celled bacterium works 24-7
4. Researchers decode genetics of rare photosynthetic bacterium
5. Bacterium sequenced makes rare form of chlorophyll
6. New process derives green gasoline from plant sugars
7. JDRF-funded clinical trial demonstrates continuous glucose monitoring improves blood sugar control
8. Sugar study is sweetener for stem cell science
9. Diabetes linked to male infertility; excess sugars in the body have direct effect on sperm quality
10. Genetic variation linked to sugary food
11. Sugar linkage could lead to better treatment for autoimmune diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... 24, 2015 Research and Markets ( ... "Global Iris Recognition Market 2015-2019" report to their ... Recognition market to grow at a CAGR of 23.5 ... covers the present scenario and the growth prospects of ... To calculate the market size, the report considers the ...
(Date:3/24/2015)... NexID Biometrics LLC, whose spoof-mitigation technology boosts protection ... beginning of shipments of version 2.0 of its industry ... in Potsdam, N.Y. , is making ... here today at the Walter E. Washington Convention Center. ... boosts the accuracy rate range to 96.5 to 99.5 ...
(Date:3/23/2015)... 23, 2015 SoundView Technology Group issues a new ... NXTD ) Wocket smart wallet. SoundView was one of the selected ... experience with the Wocket in multiple scenarios and outlets. ... and other retailers, making both debit and credit card payments.  ... says, "If the company meets their plans in 2015, it ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4
... The bubbles in your champagne that appear to jump out ... quite similar to the tiny bubbles found throughout the world,s oceans, ... the champagne bubbles are likely to raise your spirits, those in ... "Bubbles are little packets of gases that rise or fall ...
... in the American diet by as little as one-half teaspoon ... attacks and 92,000 deaths each year, according to a new ... from reductions in smoking and could save the United States ... A team from the University of California, San Francisco, ...
... PHILADELPHIA - Biologists at the University of Pennsylvania studying ... longstanding conundrum: How can organisms be robust against the ... changes? The short answer, according to University ... two requirements are often not contradictory and that an ...
Cached Biology News:Bubble physicist counts bubbles in the ocean to answer questions about climate, sound, light 2Bubble physicist counts bubbles in the ocean to answer questions about climate, sound, light 3Even small dietary reductions in salt could mean fewer heart attacks, strokes and deaths 2Even small dietary reductions in salt could mean fewer heart attacks, strokes and deaths 3Penn biologists explain how organisms can tolerate mutations, yet adapt to environmental change 2
(Date:4/21/2015)... 2015 Leading-edge research into ... will be presented at the 2nd International ... and clinicians from academia, industry and government ... Invibio Biomaterial Solutions. The world-leading solutions provider ... manufacturing and R&D for medical-device manufacturers, holds ...
(Date:4/21/2015)... Whether it’s used for troubleshooting in a factory, ... Kessler CineDrive in a cinematic studio setting, or ... is designed to help any shooter create vivid high-speed ... the TS5-H offers the same convenient touchscreen controls and streamlined ... According to Tom Boldt for Fastec, “We believe that compelling ...
(Date:4/20/2015)... Stent retriever thrombectomy, an endovascular technique ... brain reduced disability after stroke, according to a ... of the Society of Vascular and Interventional Neurology ... step forward that will change the way we ... Jovin, who is associate professor of Neurology and ...
(Date:4/20/2015)... Champaign, IL (PRWEB) April 20, 2015 ... establishment of its 12th clinical research site: PMG Research ... has assumed operation of the clinical research department at ... footprint outside the Southeast to a second region within ... 150 multi-specialty physician practice enhances PMG’s access to an ...
Breaking Biology Technology:2nd International PEEK Meeting: Invibio Biomaterial Solutions spearheads medical research for implantable PEEK polymer devices 22nd International PEEK Meeting: Invibio Biomaterial Solutions spearheads medical research for implantable PEEK polymer devices 3Fastec Imaging Releases the TS5-H High Definition High-Speed Camera 2Fastec Imaging Releases the TS5-H High Definition High-Speed Camera 3SVIN President Tudor Jovin, MD, Co-Leads Groundbreaking Stroke Study In The New England Journal Of Medicine 2SVIN President Tudor Jovin, MD, Co-Leads Groundbreaking Stroke Study In The New England Journal Of Medicine 3PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 2PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 3
... N.Y., March 24 China,s State Food ... the pioneering Lucid VivaScope(R),reflective confocal microscope in ... CEO of Lucid, a Rochester, New York-based ... improved care for dermatology,patients., Lucid,s VivaScope(R) ...
... CMPMedica has expanded,SearchMedica.com to include a number ... conditions. SearchMedica.com was co-,developed with Convera Corporation ... , a,leading provider of vertical search services ... ), SearchMedica.com has been serving primary ...
... 24 An information technology,revolution is improving ... (PROs), according to Supportive Oncology Services, Inc. ... TN. PROs are self-,assessments that measure any ... from the patient without any interpretation by ...
Cached Biology Technology:Lucid's VivaScope(R) Reflective Confocal Microscope Approved for Sale in China 2Lucid's VivaScope(R) Reflective Confocal Microscope Approved for Sale in China 3CMPMedica Expands SearchMedica.com with Multiple Additional Vertical Search Applications co-developed with Convera(R) 2CMPMedica Expands SearchMedica.com with Multiple Additional Vertical Search Applications co-developed with Convera(R) 3Patient-Reported Outcomes (PROs) Improve Cancer Treatment -- Experts Agree 2Patient-Reported Outcomes (PROs) Improve Cancer Treatment -- Experts Agree 3
...
...
...
... Radiolabeled Ligands\n\nReceptor-related research has long been enabled ... ligands selected to keep pace with new ... products and services for receptor research and ... If you do not find exactly what ...
Biology Products: