Navigation Links
T2 and collaborators announce discovery of novel clot structure biology enabled by T2HemoStat
Date:1/9/2014

e at the University of Pennsylvania.

"Polyhedrocytes are likely to be central to preventing bleeding and promoting blood flow after damage to blood vessels has begun to heal. However, when the process goes awry, in the case of clotting diseases, these tightly packed erythrocytes present a challenge to clot-busting thrombolytic agents, as they are more resistant to fibrinolysis," said co-author John W. Weisel, Ph.D., Professor of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania.

"This landmark publication demonstrates that T2HemoStat can be an important tool to identify biomarkers for companion diagnostics or new drug development, in this case, specifically targeted at highly contracted clots containing polyhedrocytes," added Tom Lowery, Ph.D., Chief Scientific Officer, T2 Biosystems and co-author in the study. "Furthermore, this new finding enabled by T2HemoStat demonstrates the power and versatility of our T2MR technology both in the research setting and as it can relate to meaningful clinical advances."

The paper, entitled "Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin", was authored by Douglas B. Cines, Tatiana Lebedeva, Chandrasekaran Nagaswami, Vincent Hayes, Walter Massefski, Rustem I. Litvinov, Lubica Rauova, Thomas J. Lowery and John W. Weisel. After identification of samples and sample conditions that form this novel clot with T2MR, the group used scanning electron and optical microscopy to determine that contracted clots consist of a meshwork of fibrin and platelet aggregates on the exterior of the clot with a closely-packed, tessellated array of compressed polyhedral erythrocytes (polyhedrocytes) on the interior.

This phenomenon was observable both in vivo and in vitro in humans and mice, and is likely caused by the force that the fibrin and platelets place upon the erythrocytes, as centrifugation of erythrocytes in the
'/>"/>

Contact: Kari Watson
kwatson@macbiocom.com
781-235-3606
MacDougall Biomedical Communications, Inc.
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. WHOI researchers, collaborators receive $1.4 million grant to study life in oceans greatest depths
2. Biogen Idec and Sangamo BioSciences Announce Global Collaboration to Develop Treatments for Hemoglobinopathies
3. MARC travel awards announced for the APS 2014 Professional Skills Training Course
4. CROS NT Ltd Announces Acquisition of MDSL International Ltd.
5. FacialNetwork.com Announces Beta Release Of "NameTag" The First Real-Time Facial Recognition App For Google Glass
6. HGH Supplements Information Website HGH.us.com Announces New Discounts on Sytropin and Genf20 Plus
7. BBSRC announces £10M of funding for advanced scientific equipment
8. Life Sciences Discovery Fund announces R&D grants
9. Genetics Society of America announces recipients of spring 2014 DeLill Nasser Award
10. CROS NT Ltd Announces Appointment of Andrew MacGarvey as CEO
11. Biophysical Society announces speakers for Future of Biophysics Burroughs Wellcome Fund Symposium
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... the long-standing belief that a deficiency in serotonin ... central role in depression. In the journal ACS ... ability to make serotonin in their brains (and thus ... show depression-like symptoms. , Donald Kuhn and colleagues ... Wayne State University School of Medicine note that depression ...
(Date:8/27/2014)... A growing number of studies have shown ... the pathogenesis of Parkinson,s disease. Previous studies ... Medical University in China have shown that ... injury, reduced divalent metal transporter 1 expression, ... substantia nigra of rotenone-induced Parkinson,s disease rats. ...
(Date:8/27/2014)... can be found in both unprocessed and processed foods. ... have been infected with Listeria from processed ... bacterium is notoriously difficult to fight because it has ... its surroundings, says Associate Professor Birgitte Kallipolitis, University of ... Biochemistry and Molecular Biology, she has published a study, ...
Breaking Biology News(10 mins):New study throws into question long-held belief about depression 2Researchers discover why Listeria bacterium is so hard to fight 2Researchers discover why Listeria bacterium is so hard to fight 3
... Agency has awarded 42 grants to teams of ... will design creative technologies to sustainability challenges in ... and the Planet (P3) Phase I awards for ... interdisciplinary teams, to design and build sustainable technologies ...
... of Ensembl Plants a freely available web ... European Molecular Biology Laboratory,s European Bioinformatics Institute (EMBL-EBI), ... USA. Ensembl Plants allows researchers worldwide to access ... different plant species. By pinpointing the genetic basis ...
... good, more must be better, right? Wrong! New research published ... shows that vitamin A plays a crucial role in energy ... has a complex negative effect on our bodies. This is ... supplements containing added vitamin A make an overdose more possible ...
Cached Biology News:New portal for plant genomics will support research into improved crops 2Too much of a good thing? Scientists explain cellular effects of vitamin A overdose and deficiency 2
(Date:8/26/2014)... , Aug. 26, 2014  NeuroSigma, Inc., a ... to develop bioelectronic technologies, today announced that it has ... U.S. Securities and Exchange Commission relating to a proposed ... of shares to be offered and the price range ... Jefferies LLC will act as the book-running ...
(Date:8/26/2014)... LONDON , Aug. 26, 2014 An ... gene structures of all Mers CoV virus ... Replikin structures back to 2012.  This conservation and sharing ... of a Synthetic Mers CoV Blocker-Vaccine™ candidate, as it did ... Shrimp vaccine, both of which have been found to ...
(Date:8/26/2014)... 2014 - A team of engineers from Singapore ... sensor network (WSN) for satellite communications. , With ... in satellite design, constructing a lightweight, low power-consuming, ... inside the satellite has always been a challenge ... the Satellite Research Centre of Nanyang Technological University ...
(Date:8/26/2014)... REHOVOT, Israel , August 26, 2014 /PRNewswire/ ... specialist, Replica 3DM, supports NHS hospitals with surgery validation using ... - Performing surgery on 3D printed models ... patient recovery and provides an effective aid for both patient ... (Nasdaq: SSYS ), a global leader of 3D ...
Breaking Biology Technology:ZigBee in the Sky 2Twelve UK Hospitals Enjoy Reduced Surgical Procedure Times and Decline in Costs by Implementing Stratasys 3D Printing Solutions 2Twelve UK Hospitals Enjoy Reduced Surgical Procedure Times and Decline in Costs by Implementing Stratasys 3D Printing Solutions 3Twelve UK Hospitals Enjoy Reduced Surgical Procedure Times and Decline in Costs by Implementing Stratasys 3D Printing Solutions 4Twelve UK Hospitals Enjoy Reduced Surgical Procedure Times and Decline in Costs by Implementing Stratasys 3D Printing Solutions 5
... was heading to the tiny island nation of The Maldives ... By all reports and expectations, she would be off the grid. ... , ,Or maybe not. After 36 hours in transit, we ... way through customs and out into the humid night air. Greeting ...
... following article is Part I of a three-part series ... series will address what business organizations and educational institutions ... , , Milwaukee, Wis. - John Psuik ... impact the growth of his company, Developer One ...
... Cancer Institute has awarded a five-year, $1.4 million renewal ... study the growth of blood vessels in brain tumors. , ... was first awarded in 2003. Kathleen Schmainda, associate professor of ... investigators are developing what they call magnetic resonance imaging contrast ...
Cached Biology Technology:Coveted vacation "disconnect" was elusive 2Coveted vacation "disconnect" was elusive 3IT workforce development: Losing the numbers game 2IT workforce development: Losing the numbers game 3IT workforce development: Losing the numbers game 4IT workforce development: Losing the numbers game 5
...
Request Info...
... collected via cardiac puncture from 3 to 4 ... It is then centrifuged and frozen at -70C. ... bottled at 4C then stored at -70C. DIRECT ... USED PEL-FREEZ COMPLEMENT, YOU CAN NOW BUY DIRECTLY ...
... and Gel Band Purification Kit, 100. For the ... DNA fragments (0.1-10 kb) from solution and from ... fragments from solution in as little as 5 ... 15 min.Prepacked glass fiber matrix columns provide consistent ...
Biology Products: