Navigation Links
T2 and collaborators announce discovery of novel clot structure biology enabled by T2HemoStat
Date:1/9/2014

e at the University of Pennsylvania.

"Polyhedrocytes are likely to be central to preventing bleeding and promoting blood flow after damage to blood vessels has begun to heal. However, when the process goes awry, in the case of clotting diseases, these tightly packed erythrocytes present a challenge to clot-busting thrombolytic agents, as they are more resistant to fibrinolysis," said co-author John W. Weisel, Ph.D., Professor of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania.

"This landmark publication demonstrates that T2HemoStat can be an important tool to identify biomarkers for companion diagnostics or new drug development, in this case, specifically targeted at highly contracted clots containing polyhedrocytes," added Tom Lowery, Ph.D., Chief Scientific Officer, T2 Biosystems and co-author in the study. "Furthermore, this new finding enabled by T2HemoStat demonstrates the power and versatility of our T2MR technology both in the research setting and as it can relate to meaningful clinical advances."

The paper, entitled "Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin", was authored by Douglas B. Cines, Tatiana Lebedeva, Chandrasekaran Nagaswami, Vincent Hayes, Walter Massefski, Rustem I. Litvinov, Lubica Rauova, Thomas J. Lowery and John W. Weisel. After identification of samples and sample conditions that form this novel clot with T2MR, the group used scanning electron and optical microscopy to determine that contracted clots consist of a meshwork of fibrin and platelet aggregates on the exterior of the clot with a closely-packed, tessellated array of compressed polyhedral erythrocytes (polyhedrocytes) on the interior.

This phenomenon was observable both in vivo and in vitro in humans and mice, and is likely caused by the force that the fibrin and platelets place upon the erythrocytes, as centrifugation of erythrocytes in the
'/>"/>

Contact: Kari Watson
kwatson@macbiocom.com
781-235-3606
MacDougall Biomedical Communications, Inc.
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. WHOI researchers, collaborators receive $1.4 million grant to study life in oceans greatest depths
2. Biogen Idec and Sangamo BioSciences Announce Global Collaboration to Develop Treatments for Hemoglobinopathies
3. MARC travel awards announced for the APS 2014 Professional Skills Training Course
4. CROS NT Ltd Announces Acquisition of MDSL International Ltd.
5. FacialNetwork.com Announces Beta Release Of "NameTag" The First Real-Time Facial Recognition App For Google Glass
6. HGH Supplements Information Website HGH.us.com Announces New Discounts on Sytropin and Genf20 Plus
7. BBSRC announces £10M of funding for advanced scientific equipment
8. Life Sciences Discovery Fund announces R&D grants
9. Genetics Society of America announces recipients of spring 2014 DeLill Nasser Award
10. CROS NT Ltd Announces Appointment of Andrew MacGarvey as CEO
11. Biophysical Society announces speakers for Future of Biophysics Burroughs Wellcome Fund Symposium
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Cell scientists have set a "mouse TRAP" to capture ... a recent study published in the Journal of ... a technique called TRAP to extract cellular and genetic ... by scientists at the Rockefeller Institute for Medical Research ... the protein-making machinery, or ribosomes, of the cell type ...
(Date:7/11/2014)... group members to reduce aggression and gain access to ... grooming activities shows a certain pattern across the day. ... Biology Letters . , Grooming between individuals in ... motives. To be groomed has hygienic benefits and is ... can provide access to infants, mating opportunities and high ...
(Date:7/11/2014)... 11, 2014 The increased risk of kidney injury ... resuscitation fluids reflects the mass of HES molecules, according ... official journal of the International Anesthesia Research Society (IARS). ... harmful effect of HES on cultured human renal proximal ... Christian Wunder and colleagues of University Hospital Wrzburg, Austria. ...
Breaking Biology News(10 mins):Baboons groom early in the day to get benefits later 2In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2
... CA, October 28, 2010 For Immediate Release ... and the Scripps Translational Science Institute has published a ... rare genetic variations that reveal whether people are predisposed ... In our modern genetic age, the entire DNA ...
... Spanish . Within the framework of a ... analyse how sleep disorders affect risk perception in driving. To ... Psychology will be employed. The purpose of the first ... sleep apnea (OSA) affects risk perception in driving, as well ...
... Nucleoprotein Machines has received an award of $16.1 million ... the National Institutes of Health (NIH). The eight-institution ... viable gene correction technology for single-gene disorders and demonstrate ... cell disease is a genetic condition present at birth ...
Cached Biology News:Scientists describe new approach for identifying genetic markers for common diseases 2Scientists describe new approach for identifying genetic markers for common diseases 3Analyzed relation between sleep disorders and risk perception by drivers with disorder 2NIH renews Nanomedicine Center focused on treating single-gene disorders for $16.1 million 2NIH renews Nanomedicine Center focused on treating single-gene disorders for $16.1 million 3NIH renews Nanomedicine Center focused on treating single-gene disorders for $16.1 million 4
(Date:7/11/2014)... July 11, 2014 Research and Markets ... Technology Market - Global Industry Analysis, Size, Share, Growth, ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... acids (either DNA or RNA) into cells. This technology ... cancer cells and protein metabolism by affecting the nuclear ...
(Date:7/11/2014)... SEATTLE , July 11, 2014  Researchers ... navigate three-dimensional images. The new technology, called Virtual ... of small structures like neurons and synapses using ... Finger,s unique technology makes 3D imaging studies orders ... resources at an unprecedented level across many areas ...
(Date:7/10/2014)... 10, 2014 Deep Knowledge Ventures ... Forum on ‘Commercialising Longevity Research’ and welcomed a ... the London Bioscience Innovation Center for the event, ... Aging Analytics Ltd. The meeting highlighted the need ... research for age-related disease, as well as the ...
(Date:7/10/2014)... Robert Harman, DVM, Founder and CEO of Vet-Stem, ... announce the relaunch of his highly informative blog, now named ... “ What are Stem Cells ?” Dr. Harman’s purpose ... in the basics of stem cell therapy so that pet ... of treatment when considering regenerative medicine. , A veterinarian by ...
Breaking Biology Technology:International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3
... the last week of August, those seven days in which we ... previous three months. For me, this week also signals the ... San Diego for DEMOmobile 2004. (Its a great lineup, so if ... In truth, I should be polishing my opening comments and ...
... will visit Chicago during an eight-day multi-state, multi-agency ... grants. , , SWIFT V Tour brings ... to brief seminar participants on their agency's Small ... Transfer (STTR) programs and to discuss research topics. ...
... expensive, well-designed websites all over the globe. Most have ... illustrations, supportive explanations about their relevant experiences and capabilities ... majority of cases, what is missing is the proof ... the owners, the management the staff and their true ...
Cached Biology Technology:Wrapping up the Summer 2Wrapping up the Summer 3Wrapping up the Summer 4Federal grant seminar coming to Chicago as part of SWIFT V Tour 2Whats Hush-Hush Marketing? 2Whats Hush-Hush Marketing? 3
... Light Antifade Kit is an aqueous-based mounting ... fluorescent dyes. This formulation of antifade minimizes ... Cascade Blue fluorophores that is often seen ... is available with the blue-fluorescent nucleic acid ...
in vitro Translation, Accessory Products...
Mouse Collagen IV...
Mycoplasma tested...
Biology Products: