Navigation Links
T cells rely on 'rheostat' to help ensure that the immune response matches the threat
Date:4/30/2013

A properly functioning immune system is a lesson in balance, providing protection against disease without attacking healthy tissue. Work led by St. Jude Children's Research Hospital scientists and published recently in Nature Immunology has identified a mechanism that helps T cells find that sweet spot where the strength of the immune response matches the threat.

The finding offers important insight into the immune response. The work also lays the foundation for advancing understanding and treatment of problems that arise when the system malfunctions, including autoimmune disorders that occur when the immune system targets healthy tissue or chronic infectious diseases and cancer where the immune response is insufficient.

T cells are the white blood cells that are the body's warriors, using a variety of weapons to combat cancer and viral infections. The receptors that extend above and below the cell membrane serve as a communication channel enabling the T cell response to match the threat. The researchers found that a component of the T cell receptor functions like a rheostat, helping to regulate a key aspect of that response the sometimes explosive production of new T cells called proliferation.

"T cells are a double-edged sword, capable of launching a fierce attack to defeat an infection but also wreaking havoc if the response is too robust and results in damaging healthy tissue," said Dario Vignali, Ph.D., vice chair of the St. Jude Department of Immunology and the paper's senior author. "These findings suggest how T cell receptors help to manage the response and possibly guard against complications resulting from an overly aggressive response."

The results highlight the role of binding regions, called immunoreceptor tyrosine-based activation motifs (ITAMs), in orchestrating an appropriate T cell response. ITAMs are located on the receptor components that extend like tails below the surface of the cell membrane, con
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Identification of stem cells raises possibility of new therapies
2. Recipe for large numbers of stem cells requires only one ingredient, says NIH/Pitt team
3. Scientists learn what makes nerve cells so strong
4. Ordinary skin cells morphed into functional brain cells
5. A novel surface marker helps scientists fish out mammary gland stem cells
6. Material screening method allows more precise control over stem cells
7. AACR news: New target plus new drug equals death of melanoma cells
8. AACR news: Six2 homeoprotein allows breast cancer cells to detach and metastasize
9. Recruiting engineered cells to work for warfighters
10. Stem cells enable personalised treatment for bleeding disorder
11. Cholesterol rafts deliver drugs inside cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2015)... ., Aug. 20, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market ... has joined The Smart Card Alliance and the EMV ... Alliance and the Smart Card Alliance Latin America (SCALA) ... industry peers and thought leaders promoting adoption of smart ...
(Date:8/18/2015)... Research and Markets ( http://www.researchandmarkets.com/research/9dmm6l/global_biometric ) ... Biometric Authentication & Identification Market: Focus On Modality, ... report to their offering. ... is expected to grow at an estimated CAGR ... over $25 billion (approximately) by 2020 as per ...
(Date:8/12/2015)... CORAL SPRINGS, Florida , August 12, 2015 /PRNewswire/ ... globally, the pace of mobile payment innovation and advanced ... continues to replace the way consumers rely on using ... forges ahead with reinventing the future for payment services ... Inc. (NASDAQ: NXTD ), :  Google, Inc. (NASDAQ: ...
Breaking Biology News(10 mins):NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 2NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 4Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6
... like hype from a late-night infomercial: It can twist ... could someday help you fend off disease! But ... several institutions including the U.S. Department of Energy,s Lawrence ... the cell,s protein-making machine, the ribosome, at key stages ...
... available in Spanish . , After corn ... looks something like slightly dampened cornmeal, though a somewhat darker ... grains with solubles" (WDGS), this byproduct is sometimes used as ... in Clay Center, Neb., are studying the pros and cons ...
... Researchers from the University of Iowa Roy J. ... that inhaled carbon black nanoparticles create a double source ... published online in the April 27 edition of the ... UI professor of internal medicine, was lead author of ...
Cached Biology News:Atomic-scale structures of ribosome could help improve antibiotics 2Atomic-scale structures of ribosome could help improve antibiotics 3Studies focus on feed ingredient's effects on levels of E. coli O157:H7 in cattle 2Carbon black nanoparticles can cause cell death 2
(Date:8/26/2015)... /PRNewswire/ - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ... the quarter ended June 30, 2015. Amounts, unless ... presented under International Financial Reporting Standards ("IFRS"). ... our Oral Amp B program, rapidly advancing towards ... Andrew Rae , President & CEO of iCo ...
(Date:8/26/2015)... SAN FRANCISCO , Aug. 26, 2015 /PRNewswire/ ... today that it has received a $1.5M Phase ... Health (NIH) to further develop its therapeutic agent ... unmet clinical need in end stage renal disease ... by the National Institute of Diabetes and Digestive ...
(Date:8/26/2015)... England , August 26, 2015 ... Ltd against Europlasma NV relating to P2i United ... have resolved their dispute in the United States ... liability on the part of either party. As a result ... Central District of California dismissed the ...
(Date:8/25/2015)... WuXi PharmaTech (Cayman) Inc. (NYSE: WX ), a ... the pharmaceutical, biotechnology, and medical device industries, and Lee,s ... Code: 0950), a research-based biopharmaceutical company headquartered in ... operations in China , today announced ... WuXi,s Laboratory Testing Division (LTD) will be the exclusive ...
Breaking Biology Technology:iCo Therapeutics Announces Second Quarter 2015 Financial Results 2iCo Therapeutics Announces Second Quarter 2015 Financial Results 3Symic Biomedical Awarded $1.5MM NIH Phase II SBIR Grant to Develop its Proteoglycan Mimetic Therapeutics to Reduce Vascular Access Failures in ESRD 2Symic Biomedical Awarded $1.5MM NIH Phase II SBIR Grant to Develop its Proteoglycan Mimetic Therapeutics to Reduce Vascular Access Failures in ESRD 3P2i Settles United States Litigation 2WuXi PharmaTech to Be Exclusive Supplier of Laboratory Testing Services to Lee's Pharm 2WuXi PharmaTech to Be Exclusive Supplier of Laboratory Testing Services to Lee's Pharm 3
... here is expanding to produce more trillions of beneficial ... clean up soil and groundwater, treat waste water, and ... its output this year from about 20,000 gallons a ... -- about 1.1 trillion per gallon. The production increase ...
... /PRNewswire/ -- US Oncology, Inc ., one ... to FORTUNE magazine,s Most Admired Companies list ... and Other category. This is the third time US Oncology has ... Most Admired Companies distinction, having been named to the list in ...
... the viability of Embryonic Stem Cells is an Illusion. Repair (Adult) ... treated all over the world, that it will be impossible for embryonic ... ever. , ... Bangkok (PRWEB) March 12, 2009 -- Don Margolis, the ...
Cached Biology Technology:Osprey Biotechnics: More Trillions of Good Bacteria 2US Oncology Named to FORTUNE Magazine's Most Admired Companies List for Third Time 2US Oncology Named to FORTUNE Magazine's Most Admired Companies List for Third Time 3Repair Stem Cell Institute Weighs in on Reversal of Embryonic Stem Cell Policy 2
... The CellSensor CRE-bla HEK 293T cell ... control of the cAMP response element (CRE). ... construct was transduced into HEK 293T cells ... to isolate clones responsive to forskolin stimulation ...
...
2ndGen Predilute antibody for staining tissue sections. Optimized for use with Zymeds Histostain-PLUS, NBA, HistoST5050, and Cap-Plus IHC Kits.Labeling: ASR...
... Nuclease catalyzes the degradation of single-stranded DNA ... products. While the nuclease prefers ssDNA over ... the enzyme degrades double-stranded DNA from both ... used for transcript mapping studies (3,4), for ...
Biology Products: