Navigation Links
T cells 'hunt' parasites like animal predators seek prey, a Penn Vet-Penn Physics study reveals
Date:5/27/2012

mune cells is governed in part by signaling proteins called chemokines. The Penn-led team demonstrated that a specific chemokine, CXCL10, and its receptor were abundantly produced in the brains of T. gondii-infected mice. When CXCL10 was blocked, mice had fewer T cells, a greater parasite burden and actively reproducing parasites.

Next the researchers sought to pinpoint the exact movement patterns of individual T cells in living tissue from T. gondii-infected mice. This was possible with multi-photon imaging, a technique that relies on a refined yet powerful microscope that can display living tissues in three dimensions in real time. Using this approach, the team found that CXCL10 appeared to play a role in the speed at which T cells are able to search for and control infection.

To the extent that immunologists had considered T-cell movement patterns at all, many assumed that they moved in a highly directed fashion to find infected cells. But when the researchers analyzed the movement of T cells, they found their data did not match what would be expected: the T cells showed no directed motion.

That's where the statistical physics expertise of Liu and Banigan came in.

"We looked at a much more complete way to quantify these tracks and found that the standard model didn't fit at all," Liu said. "After some work we managed to find a model that did fit the tracks beautifully."

"The model that finally led us down the right path," Banigan said, "had a strong signature of something really interesting," a model known as a Lvy walk.

This "walk," or a mathematically characterized path, tends to have many short "steps" and occasional long "runs." The model was not fully consistent with the data, however.

"Rather, I had to look at variations on the Lvy walk model," Banigan said, because the researchers also observed that the T cells paused between steps and runs. Like the movements of the cells, the pauses were
'/>"/>

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. NSF funds new Center for the Physics of Living Cells at Illinois
3. When cells go bad
4. The role of stem cells in renewing the cornea
5. Breast cancer cells recycle to escape death by hormonal therapy
6. Models of eel cells suggest electrifying possibilities
7. Scientists identify a molecule that coordinates the movement of cells
8. Form of Crohns disease traced to disabled gut cells
9. Cold Spring Harbor Laboratory scientists trace a novel way cells are disrupted in cancer
10. Researchers design artificial cells that could power medical implants
11. Stabilizing force for good communication between neurons and muscle cells found
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... wild, domesticated, and domesticated-wild hybridized populations of ... that within 5 to 11 generations, selection ... populations that hybridized with domesticated populations. , ... evidence that natural selection, over time, removes ... as a result of increased genetic diversity. ...
(Date:9/15/2014)... Ebola virus outbreak in West Africa, which has claimed ... a deeper understanding of the molecular biology of the ... vaccines or antiviral drugs to treat or prevent Ebola ... Virginia (UVA), USA under the leadership of Dr ... structural biologist has obtained the crystal structure of ...
(Date:9/15/2014)... cardiovascular disease (CVD) claims 17 million lives each year, ... 9.4 million. 1 New research presented by international ... Montpellier, France on September 15, 2014, suggests that milk ... , At the Milk and Dairy Products in ... risk for hypertension and CVD was examined by Dr. ...
Breaking Biology News(10 mins):Protein secrets of Ebola virus 2Dairy consumption linked to lower blood pressure and cardiovascular disease risk 2
... join the two copies of each chromosomecalled sister chromatidsto ... cells during cell division. In this way, each daughter ... parent cell. Pds5 is a protein associated with ... vertebrates there are two variants of Pds5, Pds5A and ...
... industrial cities is often an overlooked resource. Years of manufacturing ... and scare residents away from using the land. As the ... the desire to grow food in cities with the fear ... at 10:35 am, Kristen McIvor of the Pierce Conservation District ...
... Zhang, a biochemist and geneticist with Texas A&M AgriLife ... million from the National Science Foundation to further his ... ultimately could help breed more productive plants. The ... is given in "support of junior faculty who exemplify ...
Cached Biology News:CNIO researchers delve into the behavior of cohesins 2Fostering community gardens in an area with historic soil contamination 2AgriLife researcher Xiuren Zhang receives National Science Foundation CAREER grant 2
(Date:9/15/2014)... ANNAPOLIS, Maryland , 15. September 2014 /PRNewswire/ ... Week (IPAW) wird vom 12. bis 18. ... der Plasma Protein Therapeutics Association (PPTA) ... Ziele: , Das globale Bewusstsein für ... Den Beitrag von Plasmaspendern beim Retten und Verbessern ...
(Date:9/14/2014)... September 15, 2014 UMBC’s Biotechnology ... on Tuesday, October 21, 2014, from 12:00 to 1:00 ... the program’s innovative curriculum and practice-oriented instruction, designed for ... degree can help advance their career in the biotechnology ... online . , About UMBC’s Biotechnology Graduate Programs, ...
(Date:9/12/2014)... AMSTERDAM , Sept. 12, 2014   Arthur ... startup bio-bean, has won the Postcode Lottery Green Challenge ... awarded Kay euro 500,000 ($680,000 USD) at the final ... green business plan. Kay,s company uses ... advanced biofuel products, namely biodiesel and biomass pellets, used ...
(Date:9/12/2014)... 12, 2014 Sandia Biotech, Inc. announced ... agreement with STC.UNM (STC) for a technology developed by ... Albuquerque, New Mexico, and Queen Mary University of London ... the Recombinant Fluorescent Antibody Technology Platform (RFAP) was developed ... Medicine and Dr. Angray Kang from Queen Mary’s Department ...
Breaking Biology Technology:International Plasma Awareness Week feiert Spender und rückt seltene Krankheiten in den Mittelpunkt 2International Plasma Awareness Week feiert Spender und rückt seltene Krankheiten in den Mittelpunkt 3UMBC Biotechnology Graduate Programs’ Virtual Info Session, October 21, 2014 2Green Startup Bio-Bean Wins $680,000 in Postcode Lottery Green Challenge 2Green Startup Bio-Bean Wins $680,000 in Postcode Lottery Green Challenge 3Sandia Biotech and STC.UNM Announce Option Agreement to License Novel Recombinant Antibody Technology 2Sandia Biotech and STC.UNM Announce Option Agreement to License Novel Recombinant Antibody Technology 3Sandia Biotech and STC.UNM Announce Option Agreement to License Novel Recombinant Antibody Technology 4
... Corporation,s (Amex: ETC ) ("ETC" or the ... two (2) BARA-MED(R),Monoplace Hyperbaric Chambers at East Orange ... is a fully accredited, acute care hospital,located in ... of East Orange,General Hospital is run by Dr. ...
... of Enrollment in U.S. Phase II Study,of Nitazoxanide ... TAMPA, Fla., Oct. 28 Romark Laboratories, ... of studies,of nitazoxanide at the upcoming 59th Annual ... Liver Diseases (AASLD), also known as The,Liver Meeting(R), ...
... N.J., Oct. 28 BioWa, Inc. announced ... with KaloBios Pharmaceuticals, Inc.,under which BioWa licenses ... antibody-dependent cellular cytotoxicity (ADDC) of select,KaloBios therapeutic ... strategic partnership with KaloBios,",commented Dr. Masamichi Koike, ...
Cached Biology Technology:Environmental Tectonics Corporation's BioMedical Systems Division Places Two Monoplace Chambers at East Orange (NJ) General Hospital 2Environmental Tectonics Corporation's BioMedical Systems Division Places Two Monoplace Chambers at East Orange (NJ) General Hospital 3Environmental Tectonics Corporation's BioMedical Systems Division Places Two Monoplace Chambers at East Orange (NJ) General Hospital 4Romark Laboratories Announces Presentation of New Nitazoxanide Data at 59th Annual AASLD Meeting and 50th Anniversary IASL Meeting in San Francisco 2BioWa Announces License of Biowa's Potelligent(R) Technology to KaloBios Pharmaceuticals 2
Experion HighSens chips are the microfluidic chips used to perform high-sensitivity RNA analysis (picogram levels) with the Experion automated electrophoresis system. Each chip has the capacity to ru...
...
...
...
Biology Products: