Navigation Links
T cell immunotherapy: Promising results in children and adults with leukemia

complete responses. Therefore, 18 of the 24 pediatric and adult patients had ongoing complete responses at a median follow-up of 2.6 months after treatment.

The trials, a collaboration between The Children's Hospital of Philadelphia and the University of Pennsylvania, are overseen by Carl H. June, M.D., the Richard W. Vague Professor in Immunotherapy in the department of Pathology and Laboratory Medicine and director of Translational Research in Penn's Abramson Cancer Center.

Grupp presented alongside Penn investigator Michael Kalos, Ph.D., during the press program. Kalos showed that measuring the number and activity of engineered T cells in patients with both ALL and chronic lymphocytic leukemia (CLL) who were treated with this investigational approach provided a useful gauge of treatment success.

A relatively new approach in cancer treatment, this type of immunotherapy relies on T cells, the workhorses of the body's immune system. Because B cells become cancerous in specific leukemias such as ALL, CTL019 cells function as cancer hunters, killing the leukemia cells that normally evade regular T cell surveillance. Researchers first extract a patient's own T cells and genetically modify them in Penn's cell and vaccine production facility to create CTL019 cells. Bioengineering techniques are used to reprogram each patient's T cells into chimeric antigen receptor cellsthe CTL019 cellscustom-designed to bind to a protein called CD19 that exists only on the surface of B cells. Then, the cells are returned to the patient's body, where they proliferate and then eliminate B cells. Moreover, they persist in the circulation, helping to guard against the cancer's recurrence.

The current study reflects an ongoing collaboration between Grupp and the Penn Medicine scientists who originally developed this personalized cell therapy as a treatment for adult patients with CLL, another B-cell leukemia.

The CHOP/Penn research colleagues ada

Contact: Rachel Salis-Silverman
Children's Hospital of Philadelphia

Page: 1 2 3

Related biology news :

1. International gene therapy trial for bubble boy disease shows promising early results
2. Newly identified proteins make promising targets for blocking graft-vs.-host disease
3. Mouse studies reveal promising vitamin D-based treatment for MS
4. Mechanism offers promising new approach for harnessing the immune system to fight cancer
5. Scientists identify promising antiviral compounds
6. Horizon Pharma Abstract Prizes recognize promising fellows and students
7. Testing method promising for spinal cord injuries, multiple sclerosis
8. Large animal models of Huntingtons disease offer new and promising research options
9. Discovery could increase efficacy of promising cystic fibrosis drug
10. Sanford-Burnham and 60° Pharmaceuticals to pursue promising target for the treatment of dengue fever
11. Research finds promising approaches to prevent Latino childhood obesity
Post Your Comments:
Related Image:
T cell immunotherapy: Promising results in children and adults with leukemia
(Date:11/3/2014)... 3, 2014 Research and Markets has ... - Technologies, Markets and Companies" to their offering. ... and methods, which have already started to play an important ... is replacing the old fashioned bone marrow transplants. Role of ... bound to become a part of medical practice. ...
(Date:11/3/2014)... Australia report that low birth weight and preterm birth ... replacements in adulthood. Findings published in the American College ... , indicate that low birth weight and pre-term babies ... to OA as adults. , According to the ... are diagnosed with clinical OA. Symptoms of OA range ...
(Date:11/2/2014)... a child, it was fascinating to put a flashlight ... through the hand. Washington University in St. Louis engineers ... the body,s tissues to improve imaging of cancerous tissues ... PhD, the Gene K. Beare Distinguished Professor of Biomedical ... is applying a novel time-reversal technology that allows researchers ...
Breaking Biology News(10 mins):Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3Preterm, low birth-weight babies may need new hips in adulthood 2Improving imaging of cancerous tissues by reversing time 2
... Drier conditions projected to result from climate change in ... result in increased dust storm activity in the future, ... U.S. Geological Survey and the University of California, Los ... soil measurements collected over a 20-year period in Arches ...
... of high quality data on climate change and its ... climate models do not always have access to this ... the Department of Energy, the on-the-ground information will get ... Energy and the Environment. The DOE-funded project, led ...
... to make currents visible is a common practice in ... adopted and perfected by artist Paul Matisse in sculptures ... object whose movement through the liquid creates whorls that ... object align with the direction of the current; light ...
Cached Biology News:DOE grant joins climate modeling with local, regional empirical data 2MIT scientists say ocean currents cause microbes to filter light 2
(Date:11/18/2014)... Athena Signature Series: Turning Cancer ‘Off’ – featuring Dr. ... in the Regulatory Biology Laboratory at the Salk Institute, studies ... an “off switch” for drug resistance in cancer. , Learn ... is making a global impact in the fight against cancer. ... Cheryl K. Goodman, CEO of Social Global Mobile LLC, for ...
(Date:11/18/2014)... Array Architects is proud of a 30-year ... nation's hospitals and health systems. It is a niche ... careers to the advancement of both the healthcare and ... field, Laura Silvoy has been chosen to share her ... Conference. , Laura will present her Process Simulation ...
(Date:11/17/2014)... November 17, 2014 The new ... Weights " describes the challenges of becoming the ... accredited status for calibration weights in the microgram ... weight manufacturers and any scientists involved in nanotechnology ... design, handling, manufacturing and calibration of weights in ...
(Date:11/15/2014)... November 14, 2014 As part ... making significant investments in its network and logistics ... cold chain and the complex requirements of the ... focus on customized logistics and transportation, and includes ... existing facilities. There will be an emphasis on ...
Breaking Biology Technology:Array Healthcare Simulation Expert Slated to Speak at Winter Simulation Conference 2New White Paper on Microgram Weights Describes How to Achieve Traceable Measurement Down to 0.05 Milligrams 2QuickSTAT Announces Global Expansion Plan to Enhance Its Global Network and Cold Chain Logistics Capabilities for Life Sciences 2
... tech company may seem low on the priority scheme. Alternately, ... qualified people available. Neither is true. , ,The board ... mentor senior management. Eventually the board should become a entity ... the business. But at the very start, the only guarantee ...
... had the opportunity to attend an exciting Chicago networking event ... event featured a presentation by professor Alicia Loffler, who is ... at Northwestern University . , ,Lofflers presentation addressed the ... needed to make these clusters grow and prosper. , ...
... MILWAUKEE,WI.-Beware calling the next strange idea you hear strange: ... millionaire next door. , ,A panel of experienced ... Conference in Milwaukee last Wednesday have dealt with looks ... their brethren in the audience to accept the whispers ...
Cached Biology Technology:Board Pieces 2Board Pieces 3Board Pieces 4The Making of Chicago as a Biotech Cluster 2The Making of Chicago as a Biotech Cluster 3The Making of Chicago as a Biotech Cluster 4The Making of Chicago as a Biotech Cluster 5The Making of Chicago as a Biotech Cluster 6The Making of Chicago as a Biotech Cluster 7Lowering the fear factor for entrepreneurs, intra-preneurs 2Lowering the fear factor for entrepreneurs, intra-preneurs 3