Navigation Links
T cell immunotherapy: Promising results in children and adults with leukemia
Date:12/7/2013

Nearly 90 percent of children and adults with a highly aggressive form of acute lymphoblastic leukemia (ALL) showed no evidence of cancer after receiving a novel, personalized cell therapy that reprograms a patient's immune system. In pilot studies of bioengineered T cells that attack leukemia, 24 of 27 patients (89%) experienced complete responses within 28 days after treatment. In all, 27 patients received the treatment--22 children treated at The Children's Hospital of Philadelphia and five adults treated at the Hospital of the University of Pennsylvania.

Pediatric oncologist Stephan A. Grupp, M.D., Ph.D., of The Children's Hospital of Philadelphia and a Professor of Pediatrics at the Perelman School of Medicine of the University of Pennsylvania, presented outcomes and follow-up results of this immunotherapy clinical trial for pediatric and adult patients with ALL in a press program today at the annual meeting of the American Society of Hematology (ASH) in New Orleans.

"Our results serve as another important milestone in demonstrating the potential of this cell therapy for patients who have no other therapeutic options," said study author Grupp. "We are also very excited that this approach has worked and been safe in patients who have relapsed after a bone marrow transplant."

All the patients had high-risk ALL that recurred after initial treatment or resisted that treatment from the start. Patients received bioengineered "hunter" T cells called CTL019 cells.

The first child to undergo this therapy, 8-year-old Emily Whitehead, remains cancer-free since her T cell treatment in April 2012, and has gone on to enjoy typical childhood activities like going to school and playing with her dog, Lucy. Emily has appeared prominently in news articles since her doctors announced dramatic findings during the December 2012 ASH meeting.

In follow-up assessments, the researchers reported six relapses among the 24 patients with
'/>"/>

Contact: Rachel Salis-Silverman
Salis@email.chop.edu
267-970-3685
Children's Hospital of Philadelphia
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. International gene therapy trial for bubble boy disease shows promising early results
2. Newly identified proteins make promising targets for blocking graft-vs.-host disease
3. Mouse studies reveal promising vitamin D-based treatment for MS
4. Mechanism offers promising new approach for harnessing the immune system to fight cancer
5. Scientists identify promising antiviral compounds
6. Horizon Pharma Abstract Prizes recognize promising fellows and students
7. Testing method promising for spinal cord injuries, multiple sclerosis
8. Large animal models of Huntingtons disease offer new and promising research options
9. Discovery could increase efficacy of promising cystic fibrosis drug
10. Sanford-Burnham and 60° Pharmaceuticals to pursue promising target for the treatment of dengue fever
11. Research finds promising approaches to prevent Latino childhood obesity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
T cell immunotherapy: Promising results in children and adults with leukemia
(Date:2/12/2015)... 12, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce ... 62/113114 for DISTRIBUTED METHOD AND SYSTEM TO ... patent further establishes NXT-ID,s position in the emerging "Internet ... the ability for multiple devices to collaborate with one ...
(Date:2/9/2015)... -- Lintec of America recently announced an exclusive license to ... including sheets, yarns and ribbons, developed at the University ... vast industrial resources of the global Lintec Group, headquartered ... America is forming the Nano-Science and Technology Center (NSTC) ... scaling up the manufacturing and commercialization of nano engineered ...
(Date:2/5/2015)... DIEGO , Jan. 26, 2015   Epic Sciences ... of cancer, today announced that Murali Prahalad , Ph.D., ... Personalized Medicine World Conference (PMWC) 2015: Silicon Valley, which ... Mountain View, Calif. on January 26-28, 2015. ... "CTCs Come of Age as Biomarkers." Last year, Epic Sciences ...
Breaking Biology News(10 mins):NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 2NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 4Epic Sciences to Present at Personalized Medicine World Conference 2015 on the Use of Circulating Tumor Cells as Cancer Biomarkers 2
... Spanish . Fernando Rendo, biologist at the ... with the intention of completing the genealogical tree ... Country Autonomous Community (CAPVEAE) and Navarre. Concretely, he opted for ... (a kind of variation in the DNA sequence) that can ...
... of how farmers could protect themselves by growing a ... of BioScience , has highlighted economical steps that ... from global climate change, including a greater frequency of ... considered a policy priority for agriculture. The survey, by ...
... stimuli, such as the scent of your morning coffee or ... to the appropriate brain region for analysis. The coffee aroma ... the auditory cortex. That division of labor suggests that ... is mounting that brain regions can take over functions they ...
Cached Biology News:Basque thesis investigates wide diversity within certain ovine, bovine and equine breeds 2Basque thesis investigates wide diversity within certain ovine, bovine and equine breeds 3MIT-- parts of brain can switch functions 2MIT-- parts of brain can switch functions 3MIT-- parts of brain can switch functions 4
(Date:2/27/2015)... Immunovaccine Inc. (“Immunovaccine”) (TSX: IMV), ... announced that the U.S. Food and Drug Administration ... and Phase I clinical trials of the DPX-Anthrax ... co-development agreement signed with Gilead Life Sciences. The ... the DPX-Survivac. , “We have been in talks ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 FamilyFarms Group ... General Manager of State Line Farms, received the 2015 ... a producer, under the age of 35, who has ... is an honor to win the Tomorrow's Top Producer ... who won the Top Producer Award and learning from ...
(Date:2/26/2015)... , Feb. 26, 2015 S&P Capital IQ ... Stock Report coverage on MabVax Therapeutics Holdings Inc . ... a clinical stage biotechnology company focused on the development ... needs in the treatment of cancer. MabVax has discovered ... the protective immune responses generated by patients who have ...
(Date:2/26/2015)... Feb. 26, 2015   Synageva BioPharma Corp. ... company developing therapeutic products for rare disorders, today ... 2015 goals, other key objectives, and financial guidance.  ... today at 4:30 p.m. EST to review the ... To participate in today,s call by telephone, please ...
Breaking Biology Technology:Immunovaccine Inc. (TSX: IMV) receives Fast Track and Phase I trial approval for Ebola and Anthrax vaccine programs, signs co-development agreement with Gilead Sciences 2Immunovaccine Inc. (TSX: IMV) receives Fast Track and Phase I trial approval for Ebola and Anthrax vaccine programs, signs co-development agreement with Gilead Sciences 3Matt Sims Receives the 2015 Tomorrow’s Top Producer Horizon Award 2S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 2S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 3S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 4S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 5Synageva BioPharma Reports 2014 Full Year Financial Results 2Synageva BioPharma Reports 2014 Full Year Financial Results 3Synageva BioPharma Reports 2014 Full Year Financial Results 4Synageva BioPharma Reports 2014 Full Year Financial Results 5Synageva BioPharma Reports 2014 Full Year Financial Results 6Synageva BioPharma Reports 2014 Full Year Financial Results 7Synageva BioPharma Reports 2014 Full Year Financial Results 8Synageva BioPharma Reports 2014 Full Year Financial Results 9
... /PRNewswire-FirstCall/ - Medicago Inc. (TSX: MDG), a clinical-stage ... affordable vaccines based on proprietary manufacturing technologies and ... included in a report of President Obama,s Council ... to the President on Reengineering the Influenza Vaccine ...
... Inc. (Nasdaq: ONTY ) today announced ... Financial Officer and Vice President, Corporate Development, effective ... financial management, investor relations and business development. ... of financial management experience to Oncothyreon," said Robert ...
... BLOOMINGTON, Ind. -- Chemists at Indiana University Bloomington have designed ... conveniently compelled to release the ions in the presence of ... American Chemical Society today (online), IU Bloomington chemist Amar ... the molecule, how it works and, just as importantly, how ...
Cached Biology Technology:Medicago named in Presidential report on meeting the challenges of pandemic influenza 2Medicago named in Presidential report on meeting the challenges of pandemic influenza 3Medicago named in Presidential report on meeting the challenges of pandemic influenza 4ONCOTHYREON APPOINTS JULIE M. EASTLAND AS CHIEF FINANCIAL OFFICER 2IU chemists develop new 'light switch' chloride binder 2IU chemists develop new 'light switch' chloride binder 3
... The high-performance triple quadrupole 1200L sets ... today's cost-conscious environment - incorporating the ... for all liquid chromatography analytical needs. ... interface and the Transmission Quadrupole Analyzer ...
C1-inhibitor (C1-INH)...
... Bio luciferase assay. Mo Bio Laboratories offers the ... you to certify your products ATP-Free with a ... deliver them to your customers in a timely ... 3.5 x 10-12 /l, which will allow you ...
Choriongonadotropin (human, hCG)...
Biology Products: