Navigation Links
T cell discovery shows promise for Type 1 diabetes treatment: UBC-CFRI study
Date:10/5/2010

A research team from the University of British Columbia and the Child & Family Research Institute (CFRI) at BC Children's Hospital has identified the role of a type of T cell in type 1 diabetes that may lead to new treatment options for young patients.

Also known as juvenile diabetes, type 1 diabetes is an autoimmune disease primarily affecting children and young adults. In patients with type 1 diabetes, the body attacks itself by destroying insulin-producing cells in the pancreas that regulate glucose, or blood sugar.

Led by Rusung Tan, a Pathology professor in the UBC Faculty of Medicine and co-head of the Immunity in Health and Disease research cluster at CFRI, the research team has identified the increased presence of Th17 cells, a type of T cell discovered in 2005, in children newly diagnosed with type 1 diabetes.

"T cells are white blood cells and key members of the immune system that control infections," says Tan, who is also a member of the Department of Pathology & Laboratory Medicine at BC Children's Hospital and a senior scholar of the Michael Smith Foundation for Health Research. "In healthy individuals, Th17 cells provide a strong defence against bacteria and viruses by guiding the immune system to strongly attack infected targets within our bodies."

However, Th17 has been associated with other autoimmune diseases such as Crohn's disease, which suggests they can play a harmful role. Treatments designed to block Th17 cells are in clinical trials for these diseases.

"The elevated levels of Th17 cells in type 1 diabetes patients suggest that these cells may also play a key role in the early development of this disease in young patients," says Tan. "This discovery opens the door to new treatments for childhood diabetes that target Th17 cells."


'/>"/>

Contact: Brian Lin
brian.lin@ubc.ca
604-822-2234
University of British Columbia
Source:Eurekalert

Page: 1

Related biology news :

1. Research breakthrough hailed on the anniversary of gene discovery
2. Discovery of a cell that suppresses the immune system
3. Census of Marine Life celebrates decade of discovery
4. Discovery of key pathway interaction may lead to therapies that aid brain growth and repair
5. Biofuel from inedible plant material easier to produce following enzyme discovery
6. Discovery offers hope of saving sub-Saharan crops from devastating parasites
7. Gene discovery holds key to growing crops in cold climates
8. First discovery of bilirubin in a flower announced
9. Report: Discovery networks hostage-taking a rare terror event
10. New discovery suggests our lungs are innately prone to silicosis and related diseases
11. A plan to promote sustainable US scientific discovery and innovation in the 21st century is proposed in OMICS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2016)... TORONTO , 19 de diciembre de 2016  Mosaic Biomedicals ... el desarrollo acelerado de MSC-1, un anticuerpo humanizado que se espera ... en 2017, con múltiples sitios previstos a lo largo de Europa ... MSC-1 ... factor inhibidor de leucemia (LIF), una citoquina pleiotrópica que se sobreexpresa ...
(Date:12/16/2016)... -- The global wearable medical device market, in terms of value, ... 5.31 billion in 2016, at a CAGR of 18.0% during the ... ... medical devices, launch of a growing number of smartphone-based healthcare apps ... providers, and increasing focus on physical fitness. Furthermore, ...
(Date:12/15/2016)... -- ... Research and Markets has announced the addition of the "Global Military ... report forecasts the global military biometrics market to grow at a CAGR ... been prepared based on an in-depth market analysis with inputs from industry ... the coming years. The report also includes a discussion of the key ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... ... January 19, 2017 , ... DaVita Clinical Research ... of drug and device development, and Prism Clinical Research , a leader ... announced Verified Clinical Trials (VCT) has been selected by both companies ...
(Date:1/18/2017)... ... January 18, 2017 , ... Opal Kelly, a ... or PCI Express, announced the ZEM5310 USB 3.0 FPGA Module, combining a SuperSpeed ... business-card sized form factor suitable for prototyping, testing, and production-ready integration. The ZEM5310 ...
(Date:1/18/2017)... , ... January 18, 2017 , ... ... Clinical Ops Executives 2017 in its continued commitment to the advancement of the ... to discuss current issues related to clinical trial planning and management. , ...
(Date:1/18/2017)... ... January 18, 2017 , ... Researchers from a new study are stating ... low enough after prostate cancer treatment, this indicates there is still remaining prostate cancer cells ... , “ The PSA test has always been an indicator of whether a man’s prostate ...
Breaking Biology Technology: