Navigation Links
T cell discovery shows promise for Type 1 diabetes treatment: UBC-CFRI study
Date:10/5/2010

A research team from the University of British Columbia and the Child & Family Research Institute (CFRI) at BC Children's Hospital has identified the role of a type of T cell in type 1 diabetes that may lead to new treatment options for young patients.

Also known as juvenile diabetes, type 1 diabetes is an autoimmune disease primarily affecting children and young adults. In patients with type 1 diabetes, the body attacks itself by destroying insulin-producing cells in the pancreas that regulate glucose, or blood sugar.

Led by Rusung Tan, a Pathology professor in the UBC Faculty of Medicine and co-head of the Immunity in Health and Disease research cluster at CFRI, the research team has identified the increased presence of Th17 cells, a type of T cell discovered in 2005, in children newly diagnosed with type 1 diabetes.

"T cells are white blood cells and key members of the immune system that control infections," says Tan, who is also a member of the Department of Pathology & Laboratory Medicine at BC Children's Hospital and a senior scholar of the Michael Smith Foundation for Health Research. "In healthy individuals, Th17 cells provide a strong defence against bacteria and viruses by guiding the immune system to strongly attack infected targets within our bodies."

However, Th17 has been associated with other autoimmune diseases such as Crohn's disease, which suggests they can play a harmful role. Treatments designed to block Th17 cells are in clinical trials for these diseases.

"The elevated levels of Th17 cells in type 1 diabetes patients suggest that these cells may also play a key role in the early development of this disease in young patients," says Tan. "This discovery opens the door to new treatments for childhood diabetes that target Th17 cells."


'/>"/>

Contact: Brian Lin
brian.lin@ubc.ca
604-822-2234
University of British Columbia
Source:Eurekalert

Page: 1

Related biology news :

1. Research breakthrough hailed on the anniversary of gene discovery
2. Discovery of a cell that suppresses the immune system
3. Census of Marine Life celebrates decade of discovery
4. Discovery of key pathway interaction may lead to therapies that aid brain growth and repair
5. Biofuel from inedible plant material easier to produce following enzyme discovery
6. Discovery offers hope of saving sub-Saharan crops from devastating parasites
7. Gene discovery holds key to growing crops in cold climates
8. First discovery of bilirubin in a flower announced
9. Report: Discovery networks hostage-taking a rare terror event
10. New discovery suggests our lungs are innately prone to silicosis and related diseases
11. A plan to promote sustainable US scientific discovery and innovation in the 21st century is proposed in OMICS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... fall marks a new school year, a new football ... Space Station. In September, SpaceX,s Dragon spacecraft is scheduled ... and investigations as part of the company,s fourth contracted ... will be the third suite of research investigations sponsored ... Space (CASIS). With the role of managing the U.S. ...
(Date:9/16/2014)... (KXL) would likely increase oil sands extraction, according to ... non-profit organization Near Zero. The results are detailed in ... both supporters and opponents of the pipeline. ... to significantly higher greenhouse gas emissions, with the exact ... "This report examines three main scenarios discussed by participants ...
(Date:9/16/2014)... votes for independence later this week, its Government could ... that fracking is necessary, research has revealed. , The ... public perception of shale gas extraction in the UK ... north of the border are the least supportive of ... in the University,s School of Geography, said: "The clear ...
Breaking Biology News(10 mins):CASIS research set for launch aboard SpaceX mission to space station 2CASIS research set for launch aboard SpaceX mission to space station 3Keystone XL would likely raise oil sands production and greenhouse gas emissions 2Scottish people most sceptical on fracking, survey shows 2Scottish people most sceptical on fracking, survey shows 3
... Medicine and University of Crete School of Medicine researchers ... a molecular mechanism that dynamically alters the strength of ... the development of drug therapies for the cognitive deficits ... bipolar disorder, or attention deficit hyperactivity disorder (ADHD). ...
... novel gene mutation that causes X-linked mental retardation for ... to an article to be published electronically on Tuesday, ... Genetics. , Investigators F. Lucy Raymond (Cambridge Institute ... Patrick S. Tarpey (Wellcome Trust Sanger Institute, Hixton, UK) ...
... the University of California, San Diego and the University ... of estimated plant species richness. Covering several hundred thousand ... most extensive map of the distribution of biodiversity on ... study published in this week's early online issue of ...
Cached Biology News:Brain networks strengthened by closing ion channels 2Brain networks strengthened by closing ion channels 3Severe mental retardation gene mutation identified 2Biologists produce global map of plant biodiversity 2
(Date:9/17/2014)... , Sept. 17, 2014  MiMedx Group, Inc. ... processor and marketer of patent protected regenerative biomaterials ... today the publication of another peer-reviewed clinical study.    ... A Multi-center Randomized Controlled Clinical Trial Evaluating the ... Membrane Allografts and Multi-layer Compression Therapy vs. Multi-layer ...
(Date:9/17/2014)... Terracon Corporation has announced the introduction of a ... This addition to the company’s industry-leading line of custom ... available in 125 or 250 gallon capacities. It ... or less. , The new pre-engineered TerraPure tank offers ... TerraPure tank line – plus quick turnaround. An ...
(Date:9/17/2014)... Calif. , Sept. 17, 2014 ... molecular diagnostics company pioneering the field of molecular cytology, ... chief operating officer. Mr. Hall joined Veracyte ... company,s commercial entry into endocrinology. Since 2012, he has ... well as managed care and billing functions. As chief ...
(Date:9/17/2014)... , September 17, 2014 ... of action from a truly novel class ... MGB Biopharma, a biopharmaceutical company developing ... today that it has secured £4.0m ($6.4m) ... antibacterial, MGB-BP-3, against a range of Gram-positive ...
Breaking Biology Technology:MiMedx Multi-Center Randomized, Controlled VLU Clinical Study Published In Peer-Reviewed Journal 2MiMedx Multi-Center Randomized, Controlled VLU Clinical Study Published In Peer-Reviewed Journal 3MiMedx Multi-Center Randomized, Controlled VLU Clinical Study Published In Peer-Reviewed Journal 4Terracon Introduces Pre-Engineered TerraPure® Tank for Ultrapure Water Applications 2Veracyte, Inc. Announces Promotion of Christopher M. Hall To Chief Operating Officer 2Veracyte, Inc. Announces Promotion of Christopher M. Hall To Chief Operating Officer 3Veracyte, Inc. Announces Promotion of Christopher M. Hall To Chief Operating Officer 4MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 2MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 3MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 4MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 5MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 6MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 7
... Allows Accurate Marketing Claims Designed with Input from,Entire ... nation,s leading livestock,cloning companies announced today a tracking ... allow food companies to identify cloned animals,when they ... program was developed through extensive cooperative discussions,over the ...
... MATEO, Calif., Dec. 19 BioForm Medical,Inc. (Nasdaq: ... will present a company overview at the upcoming 26th ... BioForm,Medical,s presentation will take place on Monday, January 7th, ... Westin St. Francis Hotel in San Francisco,CA., A ...
... Holdings, Inc. (OTC,Bulletin Board: HTWO) announced today that ... Mirant Energy Trading LLC, a subsidiary of Mirant ... biofuel technology in utility,scale power generation applications., ... biofuel for a gas,turbine test program that will ...
Cached Biology Technology:Top U.S. Cloning Companies Announce New System to Track Cloned Livestock 2BioForm Medical to Present at the 2008 JPMorgan Healthcare Conference on January 7, 2008 2H2Diesel Holdings Announces Test Burn Agreement With Mirant Corp. 2H2Diesel Holdings Announces Test Burn Agreement With Mirant Corp. 3
Request Info...
Limit of detection: <5 pg/ml...
Request Info...
... the premium quality siRNAs you need for ... be readily ordered online by providing either ... providing the sense and antisense siRNA sequences. ... Silencer Pre-designed siRNAs, which are already designed ...
Biology Products: