Navigation Links
Systems biology approach identifies nutrient regulation of biological clock in plants
Date:3/14/2008

Using a systems biological analysis of genome-scale data from the model plant Arabidopsis, an international team of researchers identified that the master gene controlling the biological clock is sensitive to nutrient status. The study will appear in the latest issue of the Proceedings of the National Academy of Sciences. This hypothesis derived from multi-network analysis of Arabidopsis genomic data, and validated experimentally, has shed light on how nutrients affect the molecular networks controlling plant growth and development in response to nutrient sensing.

The study was conducted by a team of researchers at New York Universitys Center for Genomics and Systems Biology, Chiles Pontificia Universidad Catlica de Chile, Dartmouth College, and Cold Spring Harbor Labs. The studys lead authors are Rodrigo A. Gutirrez of the Pontificia Universidad Catlica de Chile and Gloria Coruzzi of NYUs Center for Genomics and Systems Biology. They note that the systems biology approach to uncovering nutrient regulated gene networks provides new targets for engineering traits in plants of agronomic interest such as increased nitrogen use efficiency, which could lead to reduced fertilizer cost and lowering ground water contamination by nitrates.

Scientists have previously studied how nitrogen nutrients affect gene expression as a way to understand the mechanisms that control plant growth and development. Nitrogen is an essential nutrient and a metabolic signal that is sensed and converted, resulting in the control of gene expression in plants. In addition, nitrate has been shown to serve as a signal for the control of gene expression in Arabidopsis, the first flowering plant to have its entire genome sequenced. There is existing evidence, on a gene-by-gene basis, that products of nitrogen assimilation, the amino acids glutamate (Glu) or glutamine (Gln), might serve as signals of organic nitrogen status that are sensed and in turn regulate gene expression.

To identify genome-wide responses to such organic nitrogen signals, the researchers treated Arabidopsis seedlings with inorganic nitrogen (N) in both the presence and the absence of chemicals that inhibit the assimilation into organic N and conducted a genome-wide analysis of all genes whose expression responds to inorganic or organic forms of nitrogen. Using an integrated network model of molecular interactions for Arabidopsis--constructed by the researchers--in which approximately 7,000 genes are connected by 230,000 molecular interactions, they uncovered a sub-network of genes regulated by organic nitrogen that includes a highly connected network hub CCA1, which controls a plants biological clock, and target genes involved in nitrogen assimilation.

The findings thus provide evidence that plant nutrition, like animal nutrition, is tightly linked to circadian, or biological clock, functions as scientists have previously hypothesized. Other researchers have recently found that the central clock gene Per2 is necessary for food anticipation in mice. This study indicates that nitrogen nutrition affects CCA1, the central clock gene of plants, suggesting nutritional regulation of the biological clock occurs in plants.


'/>"/>

Contact: James Devitt
james.devitt@nyu.edu
212-998-6808
New York University
Source:Eurekalert

Related biology news :

1. Small streams mitigate human influence on coastal ecosystems
2. Rats on islands disrupt ecosystems from land to sea, researchers find
3. Adapting local ecosystems can soften impact of global climate change
4. Map is first to track global human influences on ocean ecosystems
5. First map of threats to marine ecosystems shows all the worlds oceans are affected
6. Washington University increases fleet of Roche Genome Sequencer FLX Systems
7. Systems biologist finds novel solutions to fundamental biological problems
8. Accu-Time Systems, Inc. Announces Launch of Next Generation Human Capital Management (HCM) solutions: Global Series(TM)
9. Resilience concepts poised to aid management of coastal marine ecosystems
10. Brain-computer link systems on the brink of breakthrough, study finds
11. Fidelica Microsystems Announces Biometrically-Authenticated Smart Card
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... 30, 2017 The research team of The ... (3D) fingerprint identification by adopting ground breaking 3D fingerprint minutiae recovery ... of speed and accuracy for use in identification, crime investigation, immigration ... ... A research team ...
(Date:3/28/2017)... March 28, 2017 The report ... (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, VMS), ... - Global Forecast to 2022", published by MarketsandMarkets, the ... and is projected to reach USD 75.64 Billion by ... 2022. The base year considered for the study is ...
(Date:3/24/2017)... Research and Markets has announced the addition of the "Global ... to 2025" report to their offering. ... The Global Biometric Vehicle Access System Market ... the next decade to reach approximately $1,580 million by 2025. ... for all the given segments on global as well as regional ...
Breaking Biology News(10 mins):
(Date:4/19/2017)... PA (PRWEB) , ... April 18, 2017 , ... ... to Halo Labs . The move comes after the company changed focus ... new market, our new brand and our new technology,” says CEO Robert Hart. ...
(Date:4/19/2017)... ... April 19, 2017 , ... As part of ... accessible to novices as well as experienced users, attendees will gain a better ... screening tests. , Hemostasis testing quality is determined by preanalytical variables which ...
(Date:4/19/2017)... 19, 2017 Veracyte, Inc. ... it will report its first quarter 2017 financial ... 2017. Following the announcement, Veracyte,s management will host a live ... discuss the company,s financial results and business progress. ... may be accessed by visiting Veracyte,s website at  http://investor.veracyte.com . ...
(Date:4/18/2017)... ... ... For a historic seventh consecutive year, Benchmark Research along with PMG Research ... of the top two Clinical Research Sites or Network. Benchmark Research has ... times previously, and first runner up the other three years. The only awards ceremony ...
Breaking Biology Technology: