Navigation Links
System that regulates blood pressure is amiss in some healthy, young blacks
Date:5/8/2009

AUGUSTA, Ga. When stress increases blood pressure, a natural mechanism designed to bring it down by excreting more salt in the urine doesn't work well in about one-third of healthy, black adolescents, researchers report.

They hope the finding, which is being presented May 8 at the American Society of Hypertension 24th Annual Scientific Program in San Francisco, will lead to early identification of youth at risk of becoming hypertensive adults.

"The way it's supposed to work is the higher your blood pressure goes, the system is supposed to be suppressed so you urinate out more sodium and the blood pressure goes down in response," says Dr. Matthew Diamond, nephrology fellow in the Medical College of Georgia School of Medicine. Dr. Diamond, who is presenting the findings, is a finalist for the society's 2009 Young Investigator-in-Training abstract competition.

The renin-angiotensin-aldosterone system helps regulate blood pressure, prompting the kidneys to hold onto more salt and fluid if it's too low and to get rid of salt when it's high.

But when MCG researchers looked at the system's activity by measuring levels of the hormones it uses to help regulate sodium excretion, the system which worked essentially perfectly in healthy white adolescents appeared dysfunctional in a significant number of the black adolescents.

The study involved 168 15-18-year-olds with normal pressures who had been on sodium- and potassium- controlled diets for two weeks. Researchers took blood pressure, urine and blood samples as participants rested for two hours, played video games intended to stimulate environmental stress, then recovered for two hours at MCG's Georgia Prevention Institute.

"For reasons we don't understand, the black kids have improper suppression of this renin-angiotensin-aldosterone system," Dr. Diamond says.

To make sure the "fight-or-flight" mechanism designed to raise blood pressure to escape a tight spot was not to blame for holding onto sodium, the researchers measured heart rates but could find no relationship. Fat, which produces aldosterone, a hormone that can increase sodium retention, also was ruled out because participants were not obese.

"There is nothing we know about that is explaining what we are seeing yet we have some pathology here that could potentially explain difficult hypertension in kids," he says.

One of his next steps is screen participants for a genetic mutation that has been linked to hypertensive kidney disease to see if that's a factor that can be used to help identify those at risk for hypertension and kidney disease.


'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Related biology news :

1. Genetic study confirms the immune systems role in narcolepsy
2. Wildlife trade threatens public health and ecosystems
3. Toward a systems biology map of iron metabolism
4. Building the lymphatic drainage system
5. Details of bacterial injection system revealed
6. Nine Additional Virginia Law Enforcement Agencies Deploy BIO-key(R) and DaPro Systems Solution
7. Can organic cropping systems be as profitable as conventional systems?
8. Smoke from cigarettes, cooking oil, wood, shift male cardiovascular system into overdrive
9. Smoke from cigarettes, cooking oil, wood, shift male cardiovascular system into overdrive
10. Ancient ecosystem thrives millions of years below Antarctic glacier
11. Device protects transplanted pancreatic cells from the immune system
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
System that regulates blood pressure is amiss in some healthy, young blacks
(Date:1/18/2017)... , Jan. 18, 2017  In vitro diagnostic ... to mergers and acquisitions (M&A), and Kalorama Information expects ... such acquisitions have been shifting. Generally, uncertainty in reimbursement ... and the U.S. has changed the acquisitions landscape. Instead ... resulted in companies buying partners outside of their home ...
(Date:1/13/2017)... Jan. 13, 2017 Sandata Technologies, LLC, ... the homecare industry, including Electronic Visit Verification™ (EVV™), ... Justin Jugs, as Senior Vice President of Product ... years of homecare experience to Sandata, where he ... plans to align Sandata,s suite of solutions with ...
(Date:1/12/2017)... , Jan. 12, 2017  New research undertaken by ... office of the future.  1,000 participants were simply asked which ... months which we may consider standard issue.  Insights on what ... 2017 were also gathered from futurists and industry leaders including ... James Canton .  Some of ...
Breaking Biology News(10 mins):
(Date:2/18/2017)... ... February 17, 2017 , ... The ... and the Center for International Blood & Marrow Transplant Research (CIBMTR) will take ... , The combined scientific sessions offer investigators, clinicians, laboratory technicians, clinical ...
(Date:2/17/2017)... 17, 2017  BioGenex, a global leader in ... a novel system for quantitative immunohistochemistry (IHC). The ... of Rochester (NY, USA) and Konica-Minolta Inc. ( ... is able to accurately quantify the expression of ... growth factor receptor-2) in clinical samples. Quantitative IHC ...
(Date:2/16/2017)... Belgium (PRWEB) , ... February 16, 2017 , ... ... (SIOTAD) framework primarily aimed at the agricultural industry. Pilot studies are about to get ... products through IoT, Big Data and 5G innovations. The concept is expected to be ...
(Date:2/16/2017)... , Feb. 16, 2017  MDNA Life ... the development of liquid biopsy tests based on ... into an exclusive license agreement with its first ... proprietary liquid biopsy test for prostate cancer, the ... Korea . This is the first overseas ...
Breaking Biology Technology: