Navigation Links
System that regulates blood pressure is amiss in some healthy, young blacks
Date:5/8/2009

AUGUSTA, Ga. When stress increases blood pressure, a natural mechanism designed to bring it down by excreting more salt in the urine doesn't work well in about one-third of healthy, black adolescents, researchers report.

They hope the finding, which is being presented May 8 at the American Society of Hypertension 24th Annual Scientific Program in San Francisco, will lead to early identification of youth at risk of becoming hypertensive adults.

"The way it's supposed to work is the higher your blood pressure goes, the system is supposed to be suppressed so you urinate out more sodium and the blood pressure goes down in response," says Dr. Matthew Diamond, nephrology fellow in the Medical College of Georgia School of Medicine. Dr. Diamond, who is presenting the findings, is a finalist for the society's 2009 Young Investigator-in-Training abstract competition.

The renin-angiotensin-aldosterone system helps regulate blood pressure, prompting the kidneys to hold onto more salt and fluid if it's too low and to get rid of salt when it's high.

But when MCG researchers looked at the system's activity by measuring levels of the hormones it uses to help regulate sodium excretion, the system which worked essentially perfectly in healthy white adolescents appeared dysfunctional in a significant number of the black adolescents.

The study involved 168 15-18-year-olds with normal pressures who had been on sodium- and potassium- controlled diets for two weeks. Researchers took blood pressure, urine and blood samples as participants rested for two hours, played video games intended to stimulate environmental stress, then recovered for two hours at MCG's Georgia Prevention Institute.

"For reasons we don't understand, the black kids have improper suppression of this renin-angiotensin-aldosterone system," Dr. Diamond says.

To make sure the "fight-or-flight" mechanism designed to raise blood pressure to escape a tight spot was not to blame for holding onto sodium, the researchers measured heart rates but could find no relationship. Fat, which produces aldosterone, a hormone that can increase sodium retention, also was ruled out because participants were not obese.

"There is nothing we know about that is explaining what we are seeing yet we have some pathology here that could potentially explain difficult hypertension in kids," he says.

One of his next steps is screen participants for a genetic mutation that has been linked to hypertensive kidney disease to see if that's a factor that can be used to help identify those at risk for hypertension and kidney disease.


'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Related biology news :

1. Genetic study confirms the immune systems role in narcolepsy
2. Wildlife trade threatens public health and ecosystems
3. Toward a systems biology map of iron metabolism
4. Building the lymphatic drainage system
5. Details of bacterial injection system revealed
6. Nine Additional Virginia Law Enforcement Agencies Deploy BIO-key(R) and DaPro Systems Solution
7. Can organic cropping systems be as profitable as conventional systems?
8. Smoke from cigarettes, cooking oil, wood, shift male cardiovascular system into overdrive
9. Smoke from cigarettes, cooking oil, wood, shift male cardiovascular system into overdrive
10. Ancient ecosystem thrives millions of years below Antarctic glacier
11. Device protects transplanted pancreatic cells from the immune system
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
System that regulates blood pressure is amiss in some healthy, young blacks
(Date:2/1/2016)... smart wallet ( www.wocketwallet.com ) announces the launch of a new video ... Las Vegas , where Joey appeared at the Wocket ... Vegas , where Joey appeared at the Wocket booth to meet ... filmed at the Consumer Electronics Show (CES2016) in Las Vegas ... greet fans. --> --> The ...
(Date:1/27/2016)... Ohio , Jan. 27, 2016  Rite Track, ... based in West Chester, Ohio ... award winning service staff, based in Austin, ... capacity and ability to provide modifications, installations and technical ... Dovalina , CEO of PLUS, commented, "PLUS has provided ...
(Date:1/25/2016)... , Jan. 25, 2016  Glencoe Software, the ... pharma and publication industries, will provide the data management ... Centre (NPSC). ... Phenotypic analysis measures ... whole organisms, allowing comparisons between states such as health ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... ... February 10, 2016 , ... ... states, announced today the promotion of two long-standing principal investigators (PI) to the ... Medicine, Clinical Research and Development. , Dr. Laurence Chu, a Benchmark Research PI ...
(Date:2/10/2016)... ... February 10, 2016 , ... SonaCare Medical, ... and support program, Sonalink™ remote monitoring. The inaugural launch of this new technology ... 5th, connecting Dr. Samuel Peretsman to a HIFU technical expert at SonaCare Medical ...
(Date:2/10/2016)... FL (PRWEB) , ... February 10, 2016 , ... ... in regenerative medicine, has announced a new agreement with Singapore-based Global Stem Cells ... physicians from the Philippines, Thailand and Singapore in the latest adipose and bone ...
(Date:2/9/2016)... ... February 09, 2016 , ... With a presidential election in November and ... Conference will bring together over 500 top healthcare leaders for a night and day ... conference, organized by MBA students of the University of Pennsylvania’s Wharton School, will be ...
Breaking Biology Technology: