Navigation Links
System in brain -- target of class of diabetes drugs -- linked to weight gain
Date:5/1/2011

CINCINNATIUniversity of Cincinnati (UC) researchers have determined why a certain class of diabetes drugs leads to weight gain and have found that the molecular system involved (PPAR-γ found in the brain) is also triggered by consumption of high-fat foods.

The study could lead to the modification of existing diabetes therapies and even dietary recommendations to limit the action of this nuclear receptor in the brain.

The research, led by Randy Seeley, PhD, UC professor and Donald C. Harrison Endowed Chair in Medicine, appears as an advanced online publication May 1, 2011, in the journal Nature Medicine.

PPAR-γ is found in white adipose (fat) tissue where it regulates the production of fat cells. This new research describes an important role for PPAR-γ in the brain.

PPAR-γ is the target of a class of diabetes drugs called TZDs (thiazolidinediones). This class of drugs reduces blood glucose levels but also causes considerable weight gain. That weight gain, Seeley says, makes many patients reluctant to use these therapies particularly since many are already trying to lose weight to improve their diabetes.

Seeley and his team set out to determine whether or not the brain's PPAR-γ system was responsible for the weight gain associated with TZDs. The team also wanted to learn if this system in the brain was activated by a high-fat diet.

To do so, they used animal models to test how the class of drugs interacted with the brain PPAR-γ system. They found that by giving TZD drugs in the same manner that people take them, rats gained weight. This was because the drugs activated PPAR-γ in the brain. Thus, weight gain associated with this class of drugs may not be a result of action of PPAR-γ in fat as had been previously thought, but rather a result of a change in activity in parts of the brain known to regulate appetite.

Seeley's team went on to also
'/>"/>

Contact: Dama Ewbank
dama.ewbank@uc.edu
513-558-4519
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UCSB urban ecosystem research featured in leading ecology journal
2. A tale of 2 lakes: One gives early warning signal for ecosystem collapse
3. RIKEN and Max Planck Society establish Joint Research Center for Systems Chemical Biology
4. Simple fungus reveals clue to immune system protection
5. Youku Upgrades Fingerprinting System for Tougher Copyright Protection Measures
6. Ahram Biosystems Announces Launch of the Palm PCR(TM) Portable PCR System
7. FDA approves the NovoTTF-100A system for the treatment of patients with recurrent glioblastoma multiforme (GBM) brain tumors
8. Death -- not just life -- important link in marine ecosystems
9. Stress wrecks intestinal bacteria, could keep immune system on idle
10. Common nanoparticles found to be highly toxic to Arctic ecosystem
11. A better understanding of the aging immune system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... a small, icy moon of Uranus, is one of ... solar system. Despite its relatively small size, Miranda appears ... resulted in the formation of at least three remarkable ... , These coronae are visible in Miranda,s southern ... across. Arden corona, the largest, has ridges and troughs ...
(Date:9/18/2014)... and the Quebec government have discovered microplastics (in ... of Fisheries and Aquatic Sciences . , The ... industrial cleansers, to which they are commonly added ... buoyancy, they may readily pass through sewage treatment ... the world,s oceans, but have only recently been ...
(Date:9/18/2014)... that prompts millions of Americans to undertake jaunts into the ... a little longer within a century, according to new research. ... areas of the United States as summer temperatures linger later ... Global Ecology and Biogeography . For instance, the paper ... tree of New Hampshire could change color one to ...
Breaking Biology News(10 mins):Miranda: An icy moon deformed by tidal heating 2Miranda: An icy moon deformed by tidal heating 3Miranda: An icy moon deformed by tidal heating 4Miranda: An icy moon deformed by tidal heating 5Miranda: An icy moon deformed by tidal heating 6Miranda: An icy moon deformed by tidal heating 7Microplastic pollution discovered in St. Lawrence River sediments 2Fall foliage season may be later, but longer on warmer Earth 2Fall foliage season may be later, but longer on warmer Earth 3Fall foliage season may be later, but longer on warmer Earth 4
... Biochemistry and Molecular Biology and the Institute of Neuroscience ... tetanus toxin, which causes tetanus, could be extremely useful ... anxiety and anorexia, and to slow the progress of ... is a neurotoxin belonging to the same family as ...
... missing receptor molecule contributes to the growth of tumors ... been proven by a team at the Medical University ... journal Molecular Cancer Research. The team, who is supported ... discovered the possible genetic reason why the receptor molecule, ...
... to the growth of tumors in human ovaries. This ... team at the Medical University of Vienna, who published ... The team, who is supported by funding from the ... reason why the receptor molecule, which is an important ...
Cached Biology News:Tetanus toxin found to have therapeutic properties 2Nanoparticles carry cancer-killing drugs into tumor cells 2Missing Receptor Molecule Causes Tumor Growth 2
(Date:9/19/2014)... 2014 Scientists at NYU Langone Medical Center have ... of the process for turning adult cells into so-called ... vitamin C. Using the new technique in mice, the ... adult skin cells by more than 20-fold compared with ... and reliable, and thus should generally accelerate research aimed ...
(Date:9/19/2014)... NEW YORK , Sept. 19, 2014  An ... common forms of inherited neuropathies – Charcot-Marie-Tooth disease (CMT) ... feet and legs, causing extreme muscle atrophy, weakness, and ... in the US and millions worldwide. CMT is a ... use of their legs, requiring mobility devices such as ...
(Date:9/19/2014)... SAN DIEGO , Sept. 19, 2014 ... engaged in the development of high-value and difficult to ... will be presenting at the 21 st Annual ... New York . Bertrand Liang , chief ... the company,s development programs and business strategy on Friday, ...
(Date:9/19/2014)... 19, 2014 Cereal grain scientists, ... will gather October 5–8, 2014, for the AACC ... Convention Center in Providence, Rhode Island. The comprehensive ... of food scientists, chemists, microbiologists, nutritionists, and those ... production management. To date, 1,000 attendees have registered ...
Breaking Biology Technology:NYU Langone scientists report reliable and highly efficient method for making stem cells 2NYU Langone scientists report reliable and highly efficient method for making stem cells 3September is Charcot-Marie-Tooth (CMT) Awareness Month - Scheduled events, activities and important partnerships announced throughout the month! 2Pfenex to Present at Upcoming Industry Conference on September 26 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 3
... is no exception. , ,Express Payment options from ... what they're looking for - a secure, hassle-free shopping experience. ... like eBay's PayPal service because it allows them ... to individual merchants. PayPal accounts are easy to setup and ...
... Metavante Corp. , the banking and payments technology subsidiary ... the formation of a new cash-management division and the ... veteran Gary Kasik. , ,Kasik will run the division, ... manage investments, certain income statement items, payables, and receivables ...
... Madison, Wis. - Dr. Jamie Thomson and his ... this year they had developed two new lines of stem ... The breakthrough was hailed in scientific circles because it moved ... there was a catch: Even though Thomson and others derived ...
Cached Biology Technology:Express pay may be the way 2Express pay may be the way 3Why the Senate should ease stem cell restrictions 2Why the Senate should ease stem cell restrictions 3
... the professional, student, or faculty researcher, the new ... your research and improve the quality of your ... the edge that researchers using LI-COR DNA analysis ... The 4300 System is a third generation instrument ...
This free-standing work station safely ventilates fumes upwards, away from the work surface. Optional Exhaust Purification System features bonded charcoal filters that remove organic chemical vapors ...
... Ideal for biocompatibility testing at various ... of air through a clean heating ... temperature up to 140F. Transparent panels ... shields allow easy access to the ...
... Tracker Intracellular Localization Kit with TransIT-siQUEST ... approach to directly label and deliver ... efficient yet non-destructive manner, for in ... functional inhibition of target gene expression ...
Biology Products: