Navigation Links
System for eliminating salt may point to new antihypertensives
Date:8/31/2010

ts causing similar dysfunction of the B receptors.

"We also think without the B receptor function, your A's go a little bit crazy," Pollock said. Not only do the A's constrict, they promote inflammation, which can further damage blood vessels. In fact, a high-salt diet can cause even B receptors to behave badly, said Dr. Jennifer Pollock, MCG biochemist and a project leader.

Across the country, Dr. Donald Kohan, nephrologist and physiologist at the University of Utah, wants to figure out what prompts the kidneys to make more endothelin in the face of a high-salt diet. He is studying kidney cells to examine how endothelin production changes and ideally learn why. The goal, again, is drug therapies to inspire this natural phenomenon.

The results when A receptors go unchecked include stiff, tortuous blood vessels; a thick boggy pumping chamber in the heart; and other major organ damage that includes the kidney.

"The consequences are measurable targets," said Dr. Edward Inscho, MCG physiologist and a project leader, noting that treatments are available but "preventing it from occurring is something we are not very good at yet."

To help put the pieces together, Inscho is focusing on how blood vessels that feed directly into kidney filters react to a high-salt diet. Blood, containing salt, continuously flows through the kidneys. The researchers have seen that excess salt increases B receptor expression, which should help the kidneys filter more sodium then get rid of it.

"If you filter more, you have more salt available for excretion," Inscho said. He wants to know what's happening with A and B receptors inside the tiny vasculature of the kidneys. He's using B-deficient rats and drugs that block either receptor to get a better idea about both. The idea is to figure out not just how they normally work but how the system becomes dysfunctional in hypertension. "I think we are beginning to understand how the B rece
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New study sheds light on painkilling system in brain
2. Electronic tracking system can improve follow-up after an abnormal Pap test
3. Warning system inadequate to prevent swimmers from getting sick at inland lakes
4. ISU researchers discover cause of immune system avoidance of certain pathogens
5. Grant to study effects of oil and dispersants on Louisiana salt marsh ecosystem
6. Systems biology software package developed at VBI is now open source for all users
7. Drugs encased in nanoparticles travel to tumors on the surface of immune-system cells
8. Researchers discover genetic link between immune system, Parkinsons disease
9. NPL unveils quantitative means of monitoring ultrasonic cleaning systems
10. UM advanced bio-filtration system promises less Chesapeake pollution
11. NOAA report reviews ecosystem management in national marine sanctuaries
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
System for eliminating salt may point to new antihypertensives
(Date:10/15/2014)... , Oct. 15, 2014   Neurotechnology , ... announced the availability of the VeriLook Surveillance ... 3.0 provides real-time biometric face identification using live ... surveillance cameras. The new version not only identifies ... people from objects while they are moving through ...
(Date:10/14/2014)... study published in Cancer Research shows SIRT6—a ... colon cancers—can promote the development of skin cancers by ... survival of sun-damaged skin cells. , Previously considered protective, ... called sirtuins that help regulate genomic stability and prevent ... helps repair DNA damage, which can lead to cancer. ...
(Date:10/14/2014)... ITHACA, N.Y. – Scientists have sequenced the house fly ... as one might expect from an insect that thrives ... research, published Oct. 14 in the journal Genome ... and biology and of how flies quickly adapt to ... , Adult house flies (Musca domestica) carry and transmit ...
Breaking Biology News(10 mins):VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2House fly genome reveals expanded immune system 2
... produce approximately 25 percent of the total catch by ... With such a substantial portion of the nations economy ... the Gulf of Mexico region it comes as ... scrutinized by researchers across the globe. While some recent ...
... the tanker Jessica, loaded with 150,000 gallons of fuel, struck ... one of the most precious, famous and fragile ecosystems on ... numbers of unique species of flora and fauna renowned through ... of evolution by natural selection. While scores of wildlife ...
... Mo. Craniosynostosis, the premature fusion of the skull, is ... the past several years, physicians have used two procedures to ... from ear to ear, strip back the scalp of the ... had fused. The other procedure required a small incision near ...
Cached Biology News:LSU researchers challenge analyses on sustainability of Gulf fisheries 2First wind turbines on Galapagos Islands will halve diesel imports, reduce risk of future oil spills 2First wind turbines on Galapagos Islands will halve diesel imports, reduce risk of future oil spills 3First wind turbines on Galapagos Islands will halve diesel imports, reduce risk of future oil spills 4Craniosynostosis minimally invasive surgery holds more promise than old procedure 2
(Date:10/25/2014)... MA (PRWEB) October 25, 2014 ... products, is pleased to announce the release of ... the highest level of contamination containment in critical ... Class 3 and higher cleanroom environments, ValuSeal® IonX™ ... polyester knit laundered wiper that continues Berkshire’s innovative ...
(Date:10/25/2014)... 2014 Investor-Edge has initiated coverage ... CYTR ), Vertex Pharmaceuticals Inc. (NASDAQ: VRTX ... Peregrine Pharmaceuticals Inc. (NASDAQ: PPHM ), and ... companies can be accessed at: http://investor-edge.com/register . ... ended on a positive note as the Dow Jones ...
(Date:10/22/2014)... Oct. 22, 2014 Research and ... "Global DNA Diagnostics Market (Product types, Application, ... Global Trends, Company Profiles, Demand, Insights, Analysis, Research, ... report to their offering. ... applications, techniques, end users and Geography) Global Size, ...
(Date:10/22/2014)... Shimadzu Scientific Instruments introduces its Open Solution ... pain management and clinical markets. The software increases the ... allowing users to highlight and review results that are ... analysts to filter results by group or based on ... the need to sift through analytes of no interest. ...
Breaking Biology Technology:Ions Are Bygones, Berkshire Announces the Release of New Innovative Cleanroom Wipers 2Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 2Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 3Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 4Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 5Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 2Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 3Shimadzu Releases QuantAnalytics Open Access LCMS Software Package for Clinical Applications 2
... Corp. (TSX: HBP / Frankfurt: WKN 918864), ... Corp.,announces that at the Company,s Annual General Meeting ... the resolutions presented by,management, appointing KPMG LLP as ... Kay, Slawomir Majewski, and Gordon Lickrish as,directors, and ...
... Jan. 30 John Wagner, M.D., recognized as,a leader ... has joined,the team at CORD:USE Cord Blood Bank. Dr. ... cell biology will provide a,significant contribution to CORD:USE., ... member of our,distinguished team," says Edward Guindi, M.D., President ...
... NATICK, Mass., Jan. 30 Boston Scientific,Corporation (NYSE: ... the 2008 Merrill,Lynch Global Pharmaceutical, Biotechnology and Medical ... New York City., Paul LaViolette, Chief Operating ... 6, beginning at approximately 10:20,a.m. E.T. Sam Leno, ...
Cached Biology Technology:Helix BioPharma shareholders vote in favour of management 2CORD:USE Cord Blood Bank Announces the Addition of Dr. John Wagner, a Pioneer in the Use of Umbilical Cord Blood Stem Cells, to Its Scientific Advisory Board 2CORD:USE Cord Blood Bank Announces the Addition of Dr. John Wagner, a Pioneer in the Use of Umbilical Cord Blood Stem Cells, to Its Scientific Advisory Board 3Boston Scientific to Participate in Merrill Lynch Conference 2
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. ID clarifier: ...
... the Beacon 2000 instrument can be used ... Beacon 2000 Data Manager Software provides the ... directly from the instrument. These data can ... available spreadsheets, such as Microsoft Excel or ...
... This kit allows for quick and reproducible immunoprecipitation ... The system is more reproducible than regular IPs, ... protein A/G agarose without disrupting the agarose bed. ... and Release is reversible, and elution of the ...
... self locking design in ice/water bath ... product number, created to easily match ... availability yet, please order under the ... customer service for assistance. ID clarifier: ...
Biology Products: