Navigation Links
Syracuse University scientists discover new hitch to link nerve cell motors to their cargo
Date:5/25/2011

With every bodily movementfrom the blink of an eye to running a marathonnerve cells transmit signals to muscle cells. To do that, nerve cells rely on tiny molecular motors to transport chemical messengers (neurotransmitters) that excite muscles cells into action. It's a complex process, which scientists are still trying to understand. A new study by Syracuse University researchers has uncovered an important piece of the puzzle.

The study, published in the April 22 issue of the Journal of Biological Chemistry (JBC), describes the discovery of a protein that is involved in the motor-cargo mechanism that carries neurotransmitter chemicals to the nerve cell's synapse. The synapse is the junction at which electrical and chemical signals are transmitted from one nerve cell to another cell. JBC is the premier journal of the American Society for Biochemistry and Molecular Biology.

The discovery was made by a team of scientists led by George M. Langford, a cell biologist and dean of SU's College of Arts and Sciences. Team members included research associate Torsten Wollert and assistant professor Michael Cosgrove in the Department of Biology; and collaborators from Dartmouth College, the Marine Biological Laboratory at Woods Hole, and the McLaughlin Research Institute. The study was funded by the National Institutes of Health.

"The transportation of neurotransmitter vesicles to the synapse is critical to nerve cell function," Langford says. "We want to better understand all of the molecular components involved in the transport process. We have discovered another 'hitch' that links the motor to its cargo."

New insights into how the chemicals are transported could result in new kinds of drug therapy for such illnesses as Parkinson's disease, depression and injuries to the neuromuscular system, Langford says.

Neurotransmitters, produced by nerve cells, are used to signal cells in every organ system in the bodyfrom muscles to metabolism.
'/>"/>

Contact: Judy Holmes
jlholmes@syr.edu
315-443-8085
Syracuse University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Syracuse University researchers discover new way to attack some forms of leukemia
2. Syracuse University partners with Arden-Fox to advance DODs Net Zero Energy Initiative
3. Falling in love more scientific than you think, according to Syracuse University professor
4. Syracuse University team develops functionally graded shape memory polymers
5. Syracuse University research team shapes cell behavior research
6. Rice University establishes National Corrosion Center
7. Case Western Reserve University researchers track Chernobyl fallout
8. Case Western Reserve University project ties soil conservation and river management together
9. Brown University and Women & Infants Hospital expand national childrens study to Bristol County
10. NIH selects Case Western Reserve University to participate in National Childrens Study
11. US Senate confirms Clemson University engineering Dean Esin Gulari to National Science Board
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2015)... , July 21, 2015 Passwords have ... seen in the recent U.S. Office of Personnel ... to the infosec conundrum, but developers and end-users ... To address this dilemma, Biometrics-as-a-Service provider HYPR Corp. ... Tokenization SDK for third party integration. ...
(Date:7/9/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/98rrmr/biometrics_for ... "Biometrics for Banking; Market & Technology Analysis, Adoption ... offering. The adoption for banking purposes ... the forecast is that by 2020 it will ... in delivering biometric systems to the banking industry. ...
(Date:7/8/2015)... DIEGO , July 8, 2015  Trovagene, ... cell-free molecular diagnostics, today announced the launch of ... the Company,s Precision Cancer Monitoring℠ (PCM) technology for ... receiving one or a combination of the novel ... Opdivo® (nivolumab), a PD-1 inhibitor. The 50-patient study ...
Breaking Biology News(10 mins):HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 2Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 4
... Chemists at the University of California, San Diego have ... when attached to the genetic material of the hepatitis C ... chronic infectious disease that affects some 170 million people worldwide ... the Centers for Disease Control and Prevention, hepatitis C now ...
... Food-borne diseases might soon have another warrior to contend ... the University of Illinois. The new antibiotic, an analog of ... be a boon to the dairy industry as a treatment ... milk, a product of bacteria resident in the cow,s udder. ...
... Dame biologist Michael Pfrender and a team of researchers ... the University of Virginia suggests that snakes from different ... resistance to a deadly neurotoxin., The finding, which appeared ... Sciences, greatly increases scientists, understanding of the genetic ...
Cached Biology News:Discovery provides blueprint for new drugs that can inhibit hepatitis C virus 2New antibiotic could make food safer and cows healthier 2New antibiotic could make food safer and cows healthier 3New paper examines poison resistance in snakes around the world 2
(Date:7/29/2015)... / Japan (Q2 2015: +14% CER / ... on high-single-digit growth in China , as well as solid ... . Europe / Middle East ... sales) showed gains in Germany , Turkey ... +4% CER / 49% of sales) grew 11%, excluding U.S. HPV sales, on ...
(Date:7/29/2015)... ... July 29, 2015 , ... G-CON Manufacturing, Inc., the leading ... 2nd generation cell therapy POD® design. The 2nd generation portfolio not only delivers ... new POD® design. , “G-CON first offered our miniPOD CT product line ...
(Date:7/29/2015)... , July 29, 2015  Therapath Neuropathology ... announces increased partnerships with VA and Military Medical ... Nerve Fiber Density (ENFD) and Sweat Gland Nerve ... fiber neuropathy ( https://therapath.com/skin ). ... Fiber Density (ENFD) on punch skin biopsy is ...
(Date:7/29/2015)... 2015 /PRNewswire/ - RepliCel Life Sciences Inc. (OTCQB: REPCF) ... pleased to announce that the final design specifications ... locked.  Prototypes for industrial and regulatory testing will ... for CE mark clearance to market the injector ... (Photo: http://photos.prnewswire.com/prnh/20150729/248373 )  ...
Breaking Biology Technology:QIAGEN Reports Results for Second Quarter and First Half of 2015 2QIAGEN Reports Results for Second Quarter and First Half of 2015 3QIAGEN Reports Results for Second Quarter and First Half of 2015 4QIAGEN Reports Results for Second Quarter and First Half of 2015 5QIAGEN Reports Results for Second Quarter and First Half of 2015 6QIAGEN Reports Results for Second Quarter and First Half of 2015 7QIAGEN Reports Results for Second Quarter and First Half of 2015 8QIAGEN Reports Results for Second Quarter and First Half of 2015 9QIAGEN Reports Results for Second Quarter and First Half of 2015 10G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 2G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 3Neuropathology services for VA and Military health systems 2RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 2RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 3RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 4RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 5
... YORK, Nov. 30 The Michael J. Fox Foundation for ... to six research teams working to develop potentially disease-modifying therapies ... Novel Approaches to Drug Discovery for Parkinson,s Disease program, ... ELN ), a neuroscience-based biotechnology company. , The ...
... CHANGCHUN, China and LOS ANGELES, ... Board: CYXN; ,China Yongxin,Pharmaceuticals, or ,the Company,), a leading ... announced it has,completed preparation for distribution of medicines on ... The Chinese government recently formalized the nation,s Essential Drug,List ...
... , BOSTON and COPENHAGEN, Nov. ... today that the Harvard Medical School ICCB-Longwood Screening Facility ... of Excellence. ICCB-L supports investigators at Harvard Medical ... of small molecule and RNAi libraries. , MicroRNAs are ...
Cached Biology Technology:The Michael J. Fox Foundation Announces $1.5 Million in Funding to Advance Development of Drug Targets for Disease-Modifying Parkinson's Disease Treatments 2The Michael J. Fox Foundation Announces $1.5 Million in Funding to Advance Development of Drug Targets for Disease-Modifying Parkinson's Disease Treatments 3China Yongxin Pharmaceuticals Inc. to Distribute Medicines on the Essential Drug List 2China Yongxin Pharmaceuticals Inc. to Distribute Medicines on the Essential Drug List 3Exiqon Recognizes Harvard Medical School Core Facility as MicroRNA Screening Center of Excellence 2Exiqon Recognizes Harvard Medical School Core Facility as MicroRNA Screening Center of Excellence 3