Navigation Links
Syracuse University scientists discover how some bacteria may steal iron from their human hosts
Date:7/31/2008

und iron-citrate could be a source of iron for the bacteria. In a series of experiments that took place over more than two years, the researchers observed that Streptomyces could ingest iron-citrate, metabolize the iron, and use the citrate as a free source of energy. Other experiments demonstrated that the bacteria ignored citrate when it was not bonded to iron; likewise, the bacteria ignored citrate when it was bonded to other metals, such as magnesium, nickel, and cobalt.

The next task was to uncover the mechanism that triggered the bacteria to ingest iron-citrate. Computer modeling predicted that a single Streptomyces gene enabled the bacteria to identify and ingest iron-citrate. The researchers isolated the gene and added it to E. coli bacteria (which is not an Actinomycete bacteria). They found that the mutant E. coli bacteria could also ingest iron-citrate. Without the gene, E. coli could not gain access to the iron.

"It's amazing that the bacteria could learn to extract iron from their environment in this way," Doyle says. "We went into these experiments with no idea that this mechanism existed. But then, bacteria have to be creative to survive in some very hostile environments; and they've had maybe 3.5 billion years to figure it out."

The Streptomyces gene enables the bacteria to passively diffuse iron-citrate across the cell membrane, which means that the bacteria do not expend additional energy to ingest the iron. Once in the cell, the bacteria metabolize the iron and, as an added bonus, use the citrate as an energy source. Doyle's team is the first to identify this mechanism in a bacteria belonging to the Actinomycete family. The team plans further experiments to confirm that the gene performs the same signaling function in tuberculosis bacteria. If so, the mechanism could potentially be exploited in the fight against tuberculosis.

"TB bacteria have acc
'/>"/>

Contact: Sara Miller
semortim@syr.edu
315-443-9038
Syracuse University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A study by the MUHC and McGill University opens a new door to understanding cancer
2. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
3. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
4. Bioengineers at University of Pennsylvania devise nanoscale system to measure cellular forces
5. Binghamton University researchers investigate evolving malaria resistance
6. Antioxidant to retard wrinkles discovered by Hebrew University researcher
7. Society for General Microbiology 161st Meeting, University of Edinburgh
8. Boston University biomedical engineers find chink in bacterias armor
9. KAUST and American University in Cairo to collaborate on research and academic development
10. UNH becomes first university in nation to use landfill gas as primary energy source
11. University of Minnesota study refutes belief that black men have more aggressive prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... allergies and other chronic inflammatory disorders among people of ... their reduced exposure to the microbes that thrive in ... The article, published in the journal Clinical & ... centers who have less access to green spaces may ... caused by immune system dysfunction. , When our immune ...
(Date:4/23/2014)... French and German . ... and other mammals, the difference between sexes depends on one single ... in males, where the two sexual chromosomes are X and Y, ... responsible for all the morphological and physiological differences between males and ... very long time ago, the X and Y were identical, until ...
(Date:4/23/2014)... Like a hungry diner ripping open a dinner roll, ... must tear open a hydrogen molecule. Now researchers have ... the two halves of its hydrogen feast. The view ... make the catalyst work better for alternative energy uses. ... shown precisely where the hydrogen halves end up in ...
Breaking Biology News(10 mins):Rural microbes could boost city dwellers' health 2Rural microbes could boost city dwellers' health 3Male or female? 2Male or female? 3Halving hydrogen 2Halving hydrogen 3Halving hydrogen 4
... to play a pivotal role in the inception of Darwin’s ... of their significance when he collected them during his voyage ... to predict the impact the vast amount of marine microbial ... by J. Craig Venter, Ph.D., and his team ?will have ...
... option for treating atrial fibrillation, a common irregular heart ... University School of Medicine in St. Louis have developed ... a complex surgical procedure that has had the best ... simplified procedure is termed Cox-maze IV, and the surgeons ...
... have large outbreaks of Ebola virus killed tens of ... Observations published in the May issue of The American ... amplified by Ebola transmission between ape social groups. The ... the devastating impact of Ebola on wild apes. ...
Cached Biology News:Darwin's famous finches and Venter's marine microbes 2Darwin's famous finches and Venter's marine microbes 3Darwin's famous finches and Venter's marine microbes 4Darwin's famous finches and Venter's marine microbes 5Surgeons develop simpler way to cure atrial fibrillation 2Ebola outbreaks killing thousands of gorillas and chimpanzees 2
(Date:1/14/2014)... provider of strategic communications services to corporations and organizations preparing for ... United States and Europe , today ... to the firm,s Washington, D.C. office. ... years of service as Associate Commissioner for the Office of External ...
(Date:1/14/2014)... Md. , Jan. 14, 2014  Organovo announced today ... the National Institutes of Health (NIH) to help scientists ... treatments to patients on a faster timeline. Organovo is ... (NCATS) and the National Eye Institute (NEI) to develop ...
(Date:1/14/2014)... Global Record Systems, LLC, (GRS), ... solutions for patients, physicians, the biopharmaceutical industry, regulators, ... the signing of a three-year Research Collaboration Agreement ... (FDA). This initiative is designed to generate ...
(Date:1/14/2014)... 2014 During the 1600’s through the 1800’s ... Doctor’s Plague.” In this time period, doctors did not know ... times, to the death of vulnerable patients. In the same ... they may be unwittingly transmitting herpes viruses to their patients. ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3
... IP Ownership into Discussion , ... Reston, VA (PRWEB) ... of data integrity solutions, announced today that is has joined the ... protection provider of its kind within the alliance. , , ...
... Ipilimumab to be Presented -PRINCETON, N.J., April 29 ... that the following clinical abstracts for ipilimumab in melanoma ... antibody for cancer treatment, have been selected to be ... the American Society of Clinical Oncology, being held May ...
... of Net Product Sales; Quarter Highlighted by Nearly $7 Million ... Pa., April 29 ViroPharma Incorporated (Nasdaq: VPHM ... ended March 31, 2009., , ... income of $11.5 million, and GAAP net loss of $59.2 ...
Cached Biology Technology:Surety, LLC Joins Microsoft BioIT Alliance 2Surety, LLC Joins Microsoft BioIT Alliance 3Medarex Announces Presentations at Annual Meeting of the American Society of Clinical Oncology 2Medarex Announces Presentations at Annual Meeting of the American Society of Clinical Oncology 3Medarex Announces Presentations at Annual Meeting of the American Society of Clinical Oncology 4ViroPharma Incorporated Reports First Quarter 2009 Financial Results 2ViroPharma Incorporated Reports First Quarter 2009 Financial Results 3ViroPharma Incorporated Reports First Quarter 2009 Financial Results 4ViroPharma Incorporated Reports First Quarter 2009 Financial Results 5ViroPharma Incorporated Reports First Quarter 2009 Financial Results 6ViroPharma Incorporated Reports First Quarter 2009 Financial Results 7ViroPharma Incorporated Reports First Quarter 2009 Financial Results 8ViroPharma Incorporated Reports First Quarter 2009 Financial Results 9ViroPharma Incorporated Reports First Quarter 2009 Financial Results 10ViroPharma Incorporated Reports First Quarter 2009 Financial Results 11ViroPharma Incorporated Reports First Quarter 2009 Financial Results 12ViroPharma Incorporated Reports First Quarter 2009 Financial Results 13ViroPharma Incorporated Reports First Quarter 2009 Financial Results 14ViroPharma Incorporated Reports First Quarter 2009 Financial Results 15
The Magnetic Separation Rack is designed to be used for small-scale separations using magnetic particles. ,Capacity: 6 microcentrifuge tubes....
... contains 4 deuterium atoms at the 9, 10, ... use as an internal standard for the quantification ... is produced by the lipoxygenation of linoleic acid ... detected in atherosclerotic plaques, as an esterified component ...
5(S)-HETE-d8 is used as an internal standard for the quantification of 5(S)-HETE by stable isotope dilution mass spectrometry....
...
Biology Products: