Navigation Links
Syracuse University scientists discover how some bacteria may steal iron from their human hosts
Date:7/31/2008

und iron-citrate could be a source of iron for the bacteria. In a series of experiments that took place over more than two years, the researchers observed that Streptomyces could ingest iron-citrate, metabolize the iron, and use the citrate as a free source of energy. Other experiments demonstrated that the bacteria ignored citrate when it was not bonded to iron; likewise, the bacteria ignored citrate when it was bonded to other metals, such as magnesium, nickel, and cobalt.

The next task was to uncover the mechanism that triggered the bacteria to ingest iron-citrate. Computer modeling predicted that a single Streptomyces gene enabled the bacteria to identify and ingest iron-citrate. The researchers isolated the gene and added it to E. coli bacteria (which is not an Actinomycete bacteria). They found that the mutant E. coli bacteria could also ingest iron-citrate. Without the gene, E. coli could not gain access to the iron.

"It's amazing that the bacteria could learn to extract iron from their environment in this way," Doyle says. "We went into these experiments with no idea that this mechanism existed. But then, bacteria have to be creative to survive in some very hostile environments; and they've had maybe 3.5 billion years to figure it out."

The Streptomyces gene enables the bacteria to passively diffuse iron-citrate across the cell membrane, which means that the bacteria do not expend additional energy to ingest the iron. Once in the cell, the bacteria metabolize the iron and, as an added bonus, use the citrate as an energy source. Doyle's team is the first to identify this mechanism in a bacteria belonging to the Actinomycete family. The team plans further experiments to confirm that the gene performs the same signaling function in tuberculosis bacteria. If so, the mechanism could potentially be exploited in the fight against tuberculosis.

"TB bacteria have acc
'/>"/>

Contact: Sara Miller
semortim@syr.edu
315-443-9038
Syracuse University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A study by the MUHC and McGill University opens a new door to understanding cancer
2. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
3. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
4. Bioengineers at University of Pennsylvania devise nanoscale system to measure cellular forces
5. Binghamton University researchers investigate evolving malaria resistance
6. Antioxidant to retard wrinkles discovered by Hebrew University researcher
7. Society for General Microbiology 161st Meeting, University of Edinburgh
8. Boston University biomedical engineers find chink in bacterias armor
9. KAUST and American University in Cairo to collaborate on research and academic development
10. UNH becomes first university in nation to use landfill gas as primary energy source
11. University of Minnesota study refutes belief that black men have more aggressive prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... , Jan. 30, 2015  It is gratifying ... power and potential for genomic science as a means ... disease prevention and treatment.  I was honored to participate ... government-funded precision medicine program. Since the ... science of genomics—from the first sequenced genome of a ...
(Date:1/22/2015)... 13, 2015  Today, FreeWavz ( www.FreeWavz.com ), the ... campaign on Fundable, https://www.fundable.com/freewavz . FreeWavz will ... capacity to meet customer demand. Logo ... http://photos.prnewswire.com/prnh/20150113/168790 Invented by Dr. ...
(Date:1/22/2015)... POINT ROBERTS, Washington , January 20, 2015 ... technology and tech stocks, releases video from the CES 2015 ... security consultant Apollo Robbins . Apollo shows ... Wocket™ biometric smart wallet, a product of NXT-ID, Inc. (NASDAQ: ...
Breaking Biology News(10 mins):J. Craig Venter, Ph.D., Co-Founder and CEO, Human Longevity, Inc. (HLI) Participates in White House Precision Medicine Event 2FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3
... San Diego have received New Innovator Awards from the ... translation of cutting-edge science and research to improvements in ... of bioengineering at the UC San Diego Jacobs School ... of medicine at UC San Diego,s School of Medicine, ...
... in German . Scientists at the ... colleagues, have decoded the genome of the Pristionchus pacificus ... In their work, which has been published in the ... from Professor Ralf J. Sommer,s department in Tbingen have ...
... professor at the UC San Diego Jacobs School of Engineering, ... With a new $1.5 million New Innovator Award grant from ... to do just that. , The awards, announced Sept. ... of new investigators who have exceptional creativity and propose bold ...
Cached Biology News:NIH doles out $3M in new innovator awards to 2 UC San Diego faculty 2Insight into the evolution of parasitism 2Insight into the evolution of parasitism 3Generation innovation: Young UC San Diego bioengineer to use NIH grant to fuel tissue engineering 2Generation innovation: Young UC San Diego bioengineer to use NIH grant to fuel tissue engineering 3
(Date:3/2/2015)... Global Stem Cells Group.com has ... Bioengineering Co., Ltd. and its Chinese-American founder Mingjie ... stem cells training course in the City of ... Shenzhen HANK is a biotechnology company established in ... virologist, to integrate research, development, production, and sales ...
(Date:3/1/2015)... 01, 2015 Market Publishers Ltd ... quality market research promotion on Internet. MarketPublishers.com is ... worked out by DataGroup Booksellers. , Natalie Aster, ... Ltd, commented on the recent partnership agreement as ... in our team of publishers. Since 1974, the ...
(Date:2/27/2015)... Halifax, Nova Scotia (PRWEB) February 27, 2015 ... has been made aware of a fraudulent press release ... GlobeNewswire, purporting to be from Immunovaccine. This press release ... with Gilead Science, Inc. The press release did ... to the information contained within the press release. ...
(Date:2/27/2015)... Feb. 27, 2015  Pharmacyclics, Inc. (NASDAQ: ... studies for its newly developed Bruton,s tyrosine kinase ... been completed. The results of these preclinical evaluations ... Drug Administration. The feedback received from the Agency ... first-in-human study. Additional preclinical work is required to ...
Breaking Biology Technology:Global Stem Cells Group Announces Alliance with HANK Bioengineering Co., Ltd. in Shenzhen, China 2Global Stem Cells Group Announces Alliance with HANK Bioengineering Co., Ltd. in Shenzhen, China 3Market Publishers Ltd and DataGroup Booksellers Sign Partnership Agreement 2Market Publishers Ltd and DataGroup Booksellers Sign Partnership Agreement 3Immunovaccine Disclaims Hoax Press Release 2Pharmacyclics Provides Clinical Update on BTK Inhibitor for Autoimmune Diseases 2Pharmacyclics Provides Clinical Update on BTK Inhibitor for Autoimmune Diseases 3
... For the first time in Michigan, a,diseased kidney ... through a single incision., "We made several improvements ... type of procedure routinely," says Craig Rogers, M.D., Henry,Ford,s ... last week using the da Vinci Surgical System, which ...
... Provides Comprehensive Clinical Picture, Improves,Patient-Physician Communications, ... Hemophilia A patients who,use Helixate(R) FS, Antihemophilic ... tracking treatment progress in real time,thanks to ... management system recently introduced by CSL Behring. ...
... BOSTON, Aug. 25 Scimitar Equity, LLC ... Bulletin Board: VOQP), entitled,"Creating Value; Turnaround Leverages ... This review is available at website: ... a New Jersey-based biotechnology company,dedicated to becoming ...
Cached Biology Technology:State's First Single Incision Robotic Kidney Removal Performed at Henry Ford Hospital 2CSL Behring's Innovative HeliTrax(SM) System Helps Physicians Manage Hemophilia A Patients 2CSL Behring's Innovative HeliTrax(SM) System Helps Physicians Manage Hemophilia A Patients 3CSL Behring's Innovative HeliTrax(SM) System Helps Physicians Manage Hemophilia A Patients 4VioQuest Pharmaceuticals, Inc Q2/08 Review Issued by Scimitar Equity, LLC 2
... The Jouan MSC series of Class ... working conditions and certification to the ... regulation ensures that the cabinets cannot ... conditions. Natural lighting, low noise and ...
... Fluoroskan Ascent FL ... fluorometric and luminometric measurement ... long list of advanced ... and Luminoskan Ascent. Fluoroskan ...
Mouse monoclonal [AZ24] to Polo like kinase ( Abpromise for all tested applications)....
... Applied Science, which pioneered the blending of ... Fidelity and Expand Long Template PCR Systems, ... System the first product of a ... new blend combines Taq DNA Polymerase with ...
Biology Products: