Navigation Links
Syracuse University researchers discover new way to attack some forms of leukemia
Date:10/28/2008

Each year, some 29,000 adults and 2,000 children are diagnosed with leukemia, a form of cancer that is caused by the abnormal production of white blood cells in the bone marrow. Current treatments rely primarily on killing the cancer cells, which also destroys normal cells. But what if a way could be found to reprogram cancerous cells back into normal cells? A team of Syracuse University researchers believes it may have found a way to do just that.

Led by Michael Cosgrove, assistant professor of biology in SU's College of Arts and Sciences, the team discovered a way to disrupt the protein switch that is a critical component in the process to create white blood cells. Its discoveries could lead to a more effective way to treat some forms of leukemia and revolutionize the approach to treating other forms of cancer. The research was recently published online in the prestigious Journal of Biological Chemistry of the American Society for Biochemistry and Molecular Biology, and is forthcoming in the print edition.

"We believe our discovery is just the tip of the iceberg," Cosgrove says. "Our hope is that from the knowledge we have gained in understanding how these proteins work in normal cells, we will be able to find new ways to treat all types of leukemia. We also think the discoveries will have broad implications in treating other types of cancer."

To understand how white blood cells are produced, one must begin by looking at the genetic code, the DNA, which provides the blueprint for all the life processes that are carried out in cells throughout the body. All of the cells in the body begin as stem cells with the same DNA. If stretched out in one continuous strand, this genetic blueprint would be about two meters long (about six feet), yet cells somehow manage to compact this rather long DNA strand into its nucleus without tangling or disrupting the exact DNA sequence. "It's sort of like stuffing 10,000 miles of spaghetti into
'/>"/>

Contact: Judy Holmes
jlholmes@syr.edu
315-443-8085
Syracuse University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Syracuse University partners with Serum Institute of India to develop vaccines for children
2. Syracuse University scientists discover how some bacteria may steal iron from their human hosts
3. Indiana University research at American Public Health Association meeting
4. Ben-Gurion University of the Negev researchers help find that hypnosis can induce synesthesia
5. Northwest climate change is target of $3.2M in grants to University of Oregon
6. Providing toilets, safe water is top route to reducing world poverty: UN University
7. University of Leicester professor adds new perspective to rainforest debate
8. University success at national engineering awards
9. Scent on demand: Hebrew University scientists enhance the scent of flowers
10. University professor stresses links between US Navy sonar and whale strandings
11. US Senate confirms Clemson University engineering Dean Esin Gulari to National Science Board
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2015)... Maryland , June 17, 2015 ... mit DNA-Tests verbessert den Analyseprozess und senkt Laborkosten    ... Prime Standard: QIA) hat heute in den ... ® für die forensische Analyse ... zur Erstellung genetischer Fingerabdrücke bieten eine integrierte Lösung für ...
(Date:6/16/2015)... 16, 2015  With the increasing number and severity ... top concern. The recent compromise of Federal employee ... strong authentication within government agencies. HYPR Corp. ... password (OTP) authenticator, has been submitted for testing and ... 3 validation for tamper proofing. The ...
(Date:6/15/2015)... 15, 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... growing mobile commerce market, announces that its leading payment security ... at Digital Experience! @ NYC June 18th. Digital ... latest innovation in technology to over 300 of the top ... the Metropolitan Pavilion in New York City ...
Breaking Biology News(10 mins):QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 4QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 5QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 6Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 2Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 3Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 2Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 3
... effort to achieve breakthrough innovations in energy production, U.S. Deputy ... up to $122 million over five years to a multidisciplinary ... aimed at developing revolutionary methods to generate fuels directly from ... (JCAP), to be led by the California Institute of Technology ...
... clear of crocodiles and navigating around massive submerged trees, ... 25 freshwater pools of Cara Blanca, Belize, which were ... May, the divers found fossilized animal remains, bits of ... an enormous underwater cave. [Click here to ...
... This release is available in German ... have successfully measured in the ozone layer the chlorine ... ozone depletion. The doubts in the established models of ... laboratory measurements are disproved by these new atmospheric observations. ...
Cached Biology News:California team to receive up to $122 million to develop method to produce fuels from sunlight 2California team to receive up to $122 million to develop method to produce fuels from sunlight 3Extreme archaeology: Divers plumb the mysteries of sacred Maya pools 2Extreme archaeology: Divers plumb the mysteries of sacred Maya pools 3Key compound of ozone destruction detected 2
(Date:7/7/2015)... , July 7, 2015  Neogen Corporation (NASDAQ: ... agreement to expand its relationship with Illumina (NASDAQ: ... Under the agreement, Illumina will market and sell arrays ... ® BeadArray technology, to the global agrigenomics community. ... customers through its GeneSeek ® genomics laboratory in ...
(Date:7/7/2015)... ... ... uBiome, the leading microbial genomics company, is offering talented researchers with big ... laboratory analysis. The goal is to fast-track a study with the greatest potential to ... dashboard, enabling them to view and compare the results of their study, as well ...
(Date:7/7/2015)... ... July 07, 2015 , ... CSM, a leading clinical trial ... President of Finance. Morse has an extensive background in financial management and accounting, bringing ... team. In his new role, Morse will oversee all financial areas of the company ...
(Date:7/6/2015)... and CARDIFF, UK (PRWEB) , ... July 06, ... ... ophthalmology and other medical fields holds potential to reveal how blood flows in ... reduce stroke-induced damage to the brain. , A new article published in the ...
Breaking Biology Technology:Neogen signs commercialization agreement with Illumina 2uBiome to Award Grant of up to $100k for Groundbreaking Microbiome Research 2uBiome to Award Grant of up to $100k for Groundbreaking Microbiome Research 3CSM Appoints Michael Morse as Vice President of Finance 2Reducing Stroke Damage May be Next Application for OCT Technology Now Widely Used in Eye and Vision Healthcare 2Reducing Stroke Damage May be Next Application for OCT Technology Now Widely Used in Eye and Vision Healthcare 3
... Sept. 8 CeloNova BioSciences, Inc.,("CeloNova"), a ... the world,s first fully color-coded line of ... meeting of the,Cardiovascular and Interventional Radiology Society ... http://www.newscom.com/cgi-bin/prnh/20070908/CLSA008 ) Embolic microspheres ...
... 2007, Wyeth (NYSE: WYE ) will announce financial ... a one-hour conference call with,research analysts at 7:30 a.m. ... may listen to the call live or on a ... by visiting our website,at http://www.wyeth.com and clicking ...
... /Xinhua-PRNewswire-FirstCall/ -- China Technology,Development Group Corporation (Nasdaq: ... new business strategy of entering the booming ... significantly increase China,s,use of renewable energy in ... strongly believes the new business strategy will ...
Cached Biology Technology:CeloNova BioSciences Announces World's First Line of Fully Color-Coded Embolic Particles at CIRSE: Embozene(TM) Color-Advanced Microspheres 2China Technology Announces Entry to the Solar Energy Sector 2China Technology Announces Entry to the Solar Energy Sector 3
... a base medium for preparation of minimal and ... but does not contain amino acids. Both bulk ... pouch contains reagents to prepare 500 ml of ... of 10X YNB for S. cerevisiae media. Store ...
... Progesterone Receptor (PR) Competitor Assay Kits ... novel progesterone receptor binding compounds using ... utilizes a fusion of glutathione transferase ... human progesterone receptor [PR-LBD(GST)] and a ...
... Protein G bind specifically to Fc regions ... Protein G conjugates are commonly used as ... immunoglobulin subtypes from serum, hybridoma ascites fluids, ... These reagents are also commonly used to ...
... the first instrument engineered to match the ... by thousands of research centers worldwide. It ... which are ideally suited for high-speed temperature ... extremely high surface-area-to-volume ratio. ,By combining glass ...
Biology Products: