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Syracuse University research team shapes cell behavior research
Date:3/10/2011

n biomaterials research.

After confirming that cells remained viable on the substrate, Davis then investigated the changes in cell alignment on the surface that results from topography change. Davis programmed a SMP substrate that transitioned from a micron-scale grooved surface to a smooth surface. When the cells were seeded on the grooved sample at 30C, the cells lined up along the grooves of the surface. The substrates were then placed in a 37C incubator, which was the transition temperature for the substrate to recover to a smooth surface. Following shape memory recovery, the cells were observed to be randomly oriented on the substrate.

This research project aimed to determine if cells could remain viable with a change in substrate topography and determine whether cells responded to the change. The next phase of this research is to move from a 2D substrate to a 3D substrate and examine cell viability. Additionally, Henderson's team will be looking at what is going on inside the cells as a result of topography changes.

The application of shape memory principles offers potential solutions for current limitations of static substrate research in bioengineering research, such as medical devices and tissue engineering scaffolds. "For the first time, we've shown that this general concept can be used successfully with cells, which suggests that it can be extended to a number of biomaterials that could be used for scaffolds and many other applications," says Davis. Since most scaffolding is made out of polymers, Henderson envisions one day using SMPs to create scaffolds that can expand inside the body, allowing for less invasive surgical procedures.


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Contact: Ariel DuChene
adduchen@syr.edu
315-443-2546
Syracuse University
Source:Eurekalert

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