Navigation Links
Syracuse University receives $2 million from NSF
Date:11/8/2011

Principal investigator Dacheng Ren, assistant professor in the Department of Biomedical and Chemical Engineering (BMCE) in Syracuse University's L.C. Smith College of Engineering and Computer Science (LCS) and member of the Syracuse Biomaterials Institute (SBI); and co-PIs professors Rebecca Bader (BMCE and SBI), Yan-Yeung Luk (chemistry and SBI), R. "Suresh" Sureshkumar (BMCE) and Ramesh Raina (biology), have been awarded $2 million by the National Science Foundation (NSF) to conduct research on deciphering and controlling the signaling processes in bacterial multicellular systems and bacteria-host interactions.

This grant comes from the Office of Emerging Frontiers in Research and Innovation (EFRI) and was only awarded to 14 teams nationally this year.

Bacterial tolerance to antibiotics and disinfectants causes numerous problems of infections and biofouling. Bacteria achieve such tolerance by forming sessile colonies in an extracellular matrix, known as biofilms, and by forming dormant persister cells, similar to spores. Inherent in bacterial populations, persister cells are believed to play important roles in chronic infections like tuberculosis, persistent fungal infections and lung infections in cystic fibrosis patients. The dormant properties of these persister cells make them tolerant to almost all antibiotics. Therefore, infections can reoccur once a person stops antibiotic treatment since the bacteria can regrow from the persister cells and attack again.

By employing a multidisciplinary approach, the team will focus on understanding and manipulating the multicellular and inter-kingdom signaling processes of these complex systems. The team will perform experiments in the areas of material design, functional genomics, bioinformatics, molecular simulation and nanotechnology, with the main goals being to understand persister formation in biofilm development, to investigate the associated signaling processes and to synthesize functional nanoparticles for controlled release of signaling modulators to eliminate persister cells and biofilms.

This award falls into the category of engineering new technologies based on multicellular and inter-kingdom signaling (MIKS). These grants are intended to support the National Academy of Engineering's grand challenge to engineer better medicine. Due to the broad spectrum of problems and opportunities associated with persister cells and biofilms, the proposed work will have significant impacts on basic science, economy, biosecurity and health care.

Beyond any technical achievements, this project will also play an important role in transforming college engineering education. Unlike traditional projects that focus on relatively narrow topics, this project targets multicellular and inter-kingdom signaling, a highly interdisciplinary area. The advanced topics associated with this research will provide invaluable materials to teach modern biotechnology, molecular simulation, synthetic biology and bioinformatics, providing the students with crucial knowledge and skills to address the scientific, engineering and societal challenges. This research will also create exciting outreach opportunities and bring talented young people, especially underrepresented groups, into science and engineering careers.

The team is comprised of faculty from the departments of Biomedical and Chemical Engineering, along with biology and chemistry in The College of Arts and Sciences and also includes collaboration with the University of Rochester and Brookhaven National Laboratory. In addition to the PI and four co-PIs, the research team also includes Shikha Nangia Ph.D. (BMCE), Professor Kyun Koo from the University of Rochester and Oleg Gang Ph.D. from Brookhaven National Laboratory. Of the five SU professors on this grant, four are also winners of NSF's prestigious CAREER award.

"I am very excited about this award. It gives us a unique opportunity to investigate and control this complex system with new technologies from multiple fields," Ren says.

"This is a great example of the type of collaboration we hope to continue to see amongst faculty across campus," says Sureshkumar, professor and BMCE department chair.


'/>"/>
Contact: Ariel DuChene
adduchen@syr.edu
315-443-2546
Syracuse University
Source:Eurekalert

Related biology news :

1. Syracuse University researchers discover new way to attack some forms of leukemia
2. Syracuse University partners with Arden-Fox to advance DODs Net Zero Energy Initiative
3. Falling in love more scientific than you think, according to Syracuse University professor
4. Syracuse University team develops functionally graded shape memory polymers
5. Syracuse University research team shapes cell behavior research
6. Syracuse University scientists discover new hitch to link nerve cell motors to their cargo
7. Syracuse University biologist discovers key regulators for biofilm development
8. Rice University establishes National Corrosion Center
9. Case Western Reserve University researchers track Chernobyl fallout
10. Case Western Reserve University project ties soil conservation and river management together
11. Brown University and Women & Infants Hospital expand national childrens study to Bristol County
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... 2, 2016  BioMEMS devices deployed in ... on medical screening and diagnostic applications, such ... devices that facilitate and assure continuous monitoring ... are being bolstered through new opportunities offered ... acquisition coupled with wireless connectivity and low ...
(Date:2/2/2016)... Feb. 2, 2016  Based on its recent ... Sullivan recognizes US-based Intelligent Retinal Imaging Systems (IRIS) ... Award for New Product Innovation. IRIS, a prominent ... North America , is poised to set ... diabetic retinopathy market. The IRIS technology presents superior ...
(Date:1/27/2016)... Jan. 27, 2016  Rite Track, Inc. a leading ... West Chester, Ohio announced today the ... staff, based in Austin, Texas , ... to provide modifications, installations and technical support offerings for ... of PLUS, commented, "PLUS has provided world class service ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... ... February 09, 2016 , ... Clinovo , the cloud-based ... Electronic Data Capture (EDC) system ClinCaptureand its new Contract Research Organization (CRO) Partner ... Conference in San Mateo, California on February 10th and 11th. Watch 2-min ...
(Date:2/9/2016)... 9, 2016  DNAtrix, a clinical stage, ... announced that its lead product, DNX-2401, has ... an orphan medicinal product for the treatment ... glioma, strikes approximately 25,000 people a year ... http://photos.prnewswire.com/prnh/20160208/330986LOGO --> http://photos.prnewswire.com/prnh/20160208/330986LOGO ...
(Date:2/9/2016)... 9, 2016 DelveInsight,s, ... report provides in depth insights on the ... the Protein-Tyrosine Phosphatase 1B (PTP1B) Inhibitors. The ... various stages of development including Discovery, Pre-clinical, ... and Preregistration. Report covers the product clinical ...
(Date:2/8/2016)... 8, 2016 Novan, Inc. today announced that Director ... of Directors of Novan. In addition, Robert Keegan has ... North Carolina . --> North Carolina ... it received a total of $32.8 million of net proceeds in ... investor network originating throughout the Research Triangle area of ...
Breaking Biology Technology: