Navigation Links
Syracuse University receives $2 million from NSF
Date:11/8/2011

Principal investigator Dacheng Ren, assistant professor in the Department of Biomedical and Chemical Engineering (BMCE) in Syracuse University's L.C. Smith College of Engineering and Computer Science (LCS) and member of the Syracuse Biomaterials Institute (SBI); and co-PIs professors Rebecca Bader (BMCE and SBI), Yan-Yeung Luk (chemistry and SBI), R. "Suresh" Sureshkumar (BMCE) and Ramesh Raina (biology), have been awarded $2 million by the National Science Foundation (NSF) to conduct research on deciphering and controlling the signaling processes in bacterial multicellular systems and bacteria-host interactions.

This grant comes from the Office of Emerging Frontiers in Research and Innovation (EFRI) and was only awarded to 14 teams nationally this year.

Bacterial tolerance to antibiotics and disinfectants causes numerous problems of infections and biofouling. Bacteria achieve such tolerance by forming sessile colonies in an extracellular matrix, known as biofilms, and by forming dormant persister cells, similar to spores. Inherent in bacterial populations, persister cells are believed to play important roles in chronic infections like tuberculosis, persistent fungal infections and lung infections in cystic fibrosis patients. The dormant properties of these persister cells make them tolerant to almost all antibiotics. Therefore, infections can reoccur once a person stops antibiotic treatment since the bacteria can regrow from the persister cells and attack again.

By employing a multidisciplinary approach, the team will focus on understanding and manipulating the multicellular and inter-kingdom signaling processes of these complex systems. The team will perform experiments in the areas of material design, functional genomics, bioinformatics, molecular simulation and nanotechnology, with the main goals being to understand persister formation in biofilm development, to investigate the associated signaling processes and to synthesize functional nanoparticles for controlled release of signaling modulators to eliminate persister cells and biofilms.

This award falls into the category of engineering new technologies based on multicellular and inter-kingdom signaling (MIKS). These grants are intended to support the National Academy of Engineering's grand challenge to engineer better medicine. Due to the broad spectrum of problems and opportunities associated with persister cells and biofilms, the proposed work will have significant impacts on basic science, economy, biosecurity and health care.

Beyond any technical achievements, this project will also play an important role in transforming college engineering education. Unlike traditional projects that focus on relatively narrow topics, this project targets multicellular and inter-kingdom signaling, a highly interdisciplinary area. The advanced topics associated with this research will provide invaluable materials to teach modern biotechnology, molecular simulation, synthetic biology and bioinformatics, providing the students with crucial knowledge and skills to address the scientific, engineering and societal challenges. This research will also create exciting outreach opportunities and bring talented young people, especially underrepresented groups, into science and engineering careers.

The team is comprised of faculty from the departments of Biomedical and Chemical Engineering, along with biology and chemistry in The College of Arts and Sciences and also includes collaboration with the University of Rochester and Brookhaven National Laboratory. In addition to the PI and four co-PIs, the research team also includes Shikha Nangia Ph.D. (BMCE), Professor Kyun Koo from the University of Rochester and Oleg Gang Ph.D. from Brookhaven National Laboratory. Of the five SU professors on this grant, four are also winners of NSF's prestigious CAREER award.

"I am very excited about this award. It gives us a unique opportunity to investigate and control this complex system with new technologies from multiple fields," Ren says.

"This is a great example of the type of collaboration we hope to continue to see amongst faculty across campus," says Sureshkumar, professor and BMCE department chair.


'/>"/>
Contact: Ariel DuChene
adduchen@syr.edu
315-443-2546
Syracuse University
Source:Eurekalert

Related biology news :

1. Syracuse University researchers discover new way to attack some forms of leukemia
2. Syracuse University partners with Arden-Fox to advance DODs Net Zero Energy Initiative
3. Falling in love more scientific than you think, according to Syracuse University professor
4. Syracuse University team develops functionally graded shape memory polymers
5. Syracuse University research team shapes cell behavior research
6. Syracuse University scientists discover new hitch to link nerve cell motors to their cargo
7. Syracuse University biologist discovers key regulators for biofilm development
8. Rice University establishes National Corrosion Center
9. Case Western Reserve University researchers track Chernobyl fallout
10. Case Western Reserve University project ties soil conservation and river management together
11. Brown University and Women & Infants Hospital expand national childrens study to Bristol County
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... 2017 Biopharm Reports has carried out ... of nuclear magnetic resonance spectroscopy (NMR). This involved ... current practices, developments, trends and end-user plans over ... and opportunities. These areas include growth in the ... and innovation requirements, hyphenated NMR techniques, main suppliers ...
(Date:1/21/2017)... 20, 2017 Research and Markets has announced ... report to their offering. ... The global voice recognition biometrics market to grow ... The report covers the present scenario and the growth prospects ... the market size, the report considers the revenue generated from the ...
(Date:1/18/2017)...  In vitro diagnostic (IVD) companies were very active ... and Kalorama Information expects that trend to continue – ... Generally, uncertainty in reimbursement and healthcare reform in ... the acquisitions landscape. Instead of looking to buy technology, ... outside of their home country and also to increase ...
Breaking Biology News(10 mins):
(Date:2/15/2017)... Pharmaceuticals Inc. (Vanda) (NASDAQ: VNDA), today announced financial ... full year ended December 31, 2016. ... we continued to demonstrate strong growth in our ... said Mihael H. Polymeropoulos, M.D., Vanda,s President and ... 2017 milestones underscores Vanda,s commitment to bringing important ...
(Date:2/15/2017)... WARRINGTON, Pa. , Feb. 15, 2017 ... biotechnology company focused on developing aerosolized KL4 surfactant therapies ... webcast (including a slide presentation) at 8:00 AM EST ... the AEROSURF phase 2 clinical program, the recently announced ... business and development activities. To participate in ...
(Date:2/15/2017)... ... February 15, 2017 , ... ... a strategic partnership that puts Diameter Health technology in the hands of Lantana ... allows providers, exchanges, quality improvement and public health entities – all those mining ...
(Date:2/15/2017)... Feb. 15, 2017  Theravance Biopharma, Inc. (NASDAQ: ... announced that it will release financial results for the ... Monday, February 27, 2017. An accompanying ... on February 27, 2017. To participate in the live ... U.S., or (920) 663-6266 for international callers, using the ...
Breaking Biology Technology: