Navigation Links
Syracuse University biologist discovers key regulators for biofilm development

They can be found everywhereorganized communities of bacteria sticking to surfaces both inside and outside the body. These biofilms are responsible for some of the most virulent, antibiotic-resistant infections in humans; however, scientific understanding of how these communities develop is lacking.

A recent study led by a Syracuse University biologist sheds new light on the process. The scientists discovered that a complex cascade of enhancer binding proteins (EBPs) is responsible for turning on genes that initiate the formation of a biofilm. The study was published June 13 in the Proceedings of the National Academy of Sciences, one of the world's most-cited multidisciplinary scientific serials. The National Science Foundation is funding the research (link to article:

"We've discovered a complex regulatory cascade of EBPs that is designed to be highly responsive to environmental signals," says Anthony Garza, associate professor of biology in SU's College of Arts and Sciences and corresponding author for the study. "The regulatory circuit we identified is very different from that which has previously been seen." Garza's research team includes scientists from the University of Miami School of Medicine, the University of Wisconsin-Madison, and Stanford University School of Medicine.

Garza's team discovered that the regulatory network that signals biofilm development is quite complex and akin to that which is normally found in higher organisms. "Bacterial cells that form biofilms require cooperative behavior similar to cells in more complex organisms," he says. "We knew EBPs were important in initiating biofilm development, and that there was a connection between EBPs and specific biofilm genes. But we didn't know how the EBP regulatory circuit was put together." Garza's team has also begun to identify the signals that activate the EBP circuitry and the corresponding biofilm genes. Those studies are forthcoming.

The work to uncover how biofilms are genetically initiated is key to developing new ways to prevent and/or treat infected surfaces, Garza says. Bacteria are stimulated to organize into biofilms by several mechanisms, including starvation, high nutrient levels, tissue recognition, and quorum or cell-density signaling. Because it takes a lot of energy to organize, bacteria need to be certain conditions are optimal before initiating the biofilm process.

For example, Garza explains, bacterial cells can recognize desirable host tissue, such as lung tissue. Once there, the cells look around to see if enough of their buddies are around to form a biofilm. In this case, both tissue recognition and quorum signaling is at work in initiating the process.

"Unfortunately, biofilms can be up to a thousand times more antibiotic resistant than free-living bacteria," Garza says. "Once established, biofilms are extremely resistant to killing agentschemicals, cleaners, antibiotics. The key to preventing their development is in understanding how they get started."


Contact: Judy Holmes
Syracuse University

Related biology news :

1. Syracuse University scientists discover new hitch to link nerve cell motors to their cargo
2. Syracuse University research team shapes cell behavior research
3. Syracuse University team develops functionally graded shape memory polymers
4. Falling in love more scientific than you think, according to Syracuse University professor
5. Syracuse University partners with Arden-Fox to advance DODs Net Zero Energy Initiative
6. Syracuse University researchers discover new way to attack some forms of leukemia
7. Guy Harvey Ocean Foundation funds University of Miamis R.J. Dunlap Program
8. Ben-Gurion University team presents environment movement report to Israels Knesset
9. Hong Kong University leads the genomics research of scarlet fever pathogen
10. Not-so-sweet potato from Clemson University, USDA resists pests, disease
11. University of Texas at Austin professor receives Donald L. Katz Award
Post Your Comments:
(Date:11/12/2015)... , Nov. 12, 2015  A golden retriever ... Duchenne muscular dystrophy (DMD) has provided a new lead ... Children,s Hospital, the Broad Institute of MIT and Harvard ... Brazil . Cell, pinpoints ... dogs "escape" the disease,s effects. The Boston Children,s lab ...
(Date:11/11/2015)... --  MedNet Solutions , an innovative SaaS-based eClinical technology company ... to announce that it will be a Sponsor of the ... be held November 17-19 in Hamburg , ... iMedNet , MedNet,s easy-to-use, proven and affordable ... been able to deliver time and cost savings of up ...
(Date:11/9/2015)... 09, 2015 ... the "Global Law Enforcement Biometrics Market ... --> ) has announced the ... Biometrics Market 2015-2019" report to their ... ( ) has announced the addition ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... 2015 Cepheid (NASDAQ: CPHD ) today ... following conference, and invited investors to participate via webcast. ...      Tuesday, December 1, 2015 at 11.00 a.m. Eastern Time ...      Tuesday, December 1, 2015 at 11.00 a.m. Eastern Time ... New York, NY      Tuesday, December 1, 2015 ...
(Date:11/24/2015)... ... November 24, 2015 , ... International ... and one of the premier annual events for pharmaceutical manufacturing: 2015 Annual Meeting. ... 2015, where ISPE hosted the largest number of attendees in more than a ...
(Date:11/24/2015)... ... ... This fall, global software solutions leader SAP and AdVenture Capital brought together ... their BIG ideas to improve health and wellness in their schools. , Now, the ... title of SAP's Teen Innovator, an all-expenses paid trip to Super Bowl 50, and ...
(Date:11/24/2015)... Ltd. (OTCQB: TIKRF) today announced that its Annual General Meeting of Shareholders ... Israel time, at the law offices of Goldfarb Seligman ... Floor, Tel Aviv, Israel . ... to the Board of Directors; , election of Liat ... an amendment to certain terms of options granted to our Chief Executive ...
Breaking Biology Technology: