Navigation Links
Synthetic virus supports a bat origin for SARS
Date:11/25/2008

SARS severe acute respiratory syndrome alarmed the world five years ago as the first global pandemic of the 21st century. The coronavirus (SARS-CoV) that sickened more than 8,000 people and killed nearly 800 of them may have originated in bats, but the actual animal source is not known.

In an effort to understand how SARS-CoV may have jumped from bats to humans, a team of investigators from Vanderbilt University Medical Center and the University of North Carolina at Chapel Hill has now generated a synthetic SARS-like bat coronavirus. The virus the largest replicating synthetic organism ever made is infectious in cultured cells and mice, the researchers report in the Proceedings of the National Academy of Sciences.

The findings identify pathways by which a bat coronavirus may have adapted to infect humans. The studies also provide a model approach for rapid identification, analysis and public health responses to future natural or intentional virus epidemics.

Zoonotic viruses animal pathogens that can cause disease in humans pose a serious threat to public health, said Mark Denison, M.D., professor of Pediatrics at Vanderbilt and a co-leader of the research with Ralph Baric, Ph.D., professor of Epidemiology at UNC.

"It's becoming more and more clear that new human epidemics will continue to originate in animals," said Denison, who is also an associate professor of Microbiology & Immunology. "However, the mechanisms of trans-species movement and adaptation of viruses from animals to humans remain poorly understood."

At the time of the SARS epidemic, the culprit virus was rapidly identified as a coronavirus (SARS-CoV). But it didn't look like the two human coronaviruses that were known, which cause 20 percent to 30 percent of common colds, and the animal "reservoir" (the original animal host for the virus) remained elusive.

Investigators became convinced that bats were the likely source, but bat coronav
'/>"/>

Contact: John Howser
john.howser@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Chloroplast f and m Thioredoxins Discovered in Nonphotosynthetic Tissues
2. Synthetic compound promotes death of lung-cancer cells, tumors
3. Experts from Stevens, Merck, publish joint paper, Biosynthetic Studies of Platensimycin
4. Researchers decode genetics of rare photosynthetic bacteria
5. Researchers decode genetics of rare photosynthetic bacterium
6. Synthetic molecules may be less expensive alternative to therapeutic antibodies, researchers find
7. Berkeley researchers identify photosynthetic dimmer switch
8. Oregano oil works as well as synthetic insecticides to tackle common beetle pest
9. New projects to raise UK profile in synthetic biology
10. Synthetic Biology: funders move to address social and ethical challenges
11. Synthetic cocoa chemical slows growth of tumors in human cell lines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/12/2015)... 12, 2015 Beta Systems ... and access management (IAM) solution for a fixed ... Beta System,s new IAM package, customers benefit from ... from multiple IAM implementations across different industries. The ... well as any necessary services and consulting. It ...
(Date:3/10/2015)... Colo. , March 10, 2015 ... Flight "Personalized Medicine in Human Space ... and Thomas J. Goodwin , Ph.D. was recently ... of the past two years. Specifically, "Personalized ... most downloaded scientific papers published in 2013 and 2014 ...
(Date:3/3/2015)... FOREST, Calif. , March 3, 2015 ... the leading provider of advanced cryogenic logistics ... markets including immunotherapies, stem cells, cell lines, ... and reproductive medicine, today announced the expansion ... Cancer Research Centers, ("Fred Hutch") Clinical ...
Breaking Biology News(10 mins):Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2"Personalized Medicine in Human Space Flight" Listed Among Most Influential Papers of 2013 and 2014 2Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 2Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 3
... is emerging for how important it is for pregnant women ... every day seem to have children who are less likely ... study from the Sahlgrenska Academy at the University of ... with Linkping University, which is conducting a population study called ...
... awarded $6.27 million to develop an interactive software system ... home. The funding, which covers a two-year period, includes ... Projects Agency-Energy (ARPA-E), About $1.28 million in matching grants ... Energy Commission. The Stanford team will focus on ...
... Origin of Species 150 years ago, he deliberately avoided the ... mention of the ,Creator, in the last paragraph of the ... commit on the matter. An international team, led by Juli ... idea and shows that the British naturalist did explain in ...
Cached Biology News:Vegetables can protect unborn child against diabetes 2Stanford researchers awarded $6.27 million to study energy efficiency and human behavior 2Charles Darwin really did have advanced ideas about the origin of life 2
(Date:3/31/2015)... 31, 2015 Materials in Society ...   June 30 2015   Elsevier , ... and services and publishing home of Materials Today , ... the Materials in Society  Lecture Series . ... 8 th International Conference on Materials for Advanced Technologies ...
(Date:3/31/2015)... LAKE CITY , March 31, 2015  The ... milestone with the selection of ten proposals that ... MCRI is the first patient-led, scientifically validated funding ... Stage 2 of the MCRI included ... careful review of a large number of innovative ...
(Date:3/31/2015)... Diasome Pharmaceuticals, Inc. ( http://www.diasome.com ) has ... United States patent has recently been allowed for the ... Entitled “Lipid Construct for Delivery of Insulin to a ... to the use of Diasome’s proprietary Hepatocyte Directed Vesicles ... more effectively reach the liver’s metabolic cells, called hepatocytes. ...
(Date:3/30/2015)... , March 30, 2015  Heidrick & Struggles (Nasdaq: ... , leadership consulting and culture shaping ... the firm to lead its global Healthcare and Life Sciences ... and Life Sciences, Mitchell will lead a team of more ... Europe and Asia ...
Breaking Biology Technology:Elsevier Materials Science Council Introduces the Materials in Society Lecture Series at the International Conference on Materials for Advanced Technologies (ICMAT) 2Elsevier Materials Science Council Introduces the Materials in Society Lecture Series at the International Conference on Materials for Advanced Technologies (ICMAT) 3Myeloma Crowd Research Initiative Selects 10 High-Risk Multiple Myeloma Proposals For Further Review 2Diasome Pharmaceuticals, Inc. Announces Notice of Allowance from US PTO for Liver Targeting System for Insulin 2Heidrick & Struggles Strengthens Leadership of Healthcare - Life Sciences Practice 2
... Technology, Inc. announced today that Jim Bullock has been ... company.  Before joining Zyga Technology, Jim was President and ... Boston Scientific.  Prior to Atritech, Jim was President and ... St. Jude Medical.  (Logo: http://photos.prnewswire.com/prnh/20110118/CG30384LOGO ...
... BEIJING, January 16, 2012 Elsevier, ... information products and services, announced today that its ... management, NursingChina , is now available online. ... online reference product available in China, featuring skills ...
... in a wide variety of applications from food ... applications. Thermal analysis is routinely used to analyze ... to use nanostructured materials has made bulk techniques ... force microscope-based technique called nanoscale thermal analysis (nanoTA) ...
Cached Biology Technology:Zyga Technology, Inc. Announces the Appointment of Jim Bullock as President and CEO 2Elsevier Launches Bilingual International Nursing Skill Training and Management Platform: NursingChina.com 2Elsevier Launches Bilingual International Nursing Skill Training and Management Platform: NursingChina.com 3Magnetic actuation enables nanoscale thermal analysis 2
The Wellwash 4 Mk 2 microplate washer combines flexibility, simplicity and ease of use. This reliable microplate washer meets the exacting standards of today's ELISA assay requirements....
... genetically engineered endonuclease. This unique enzyme degrades ... having no proteolytic activity. It is effective ... possesses an exceptionally high specific activity. Ideal ... proteins, its use enables compliance with FDA ...
... microRNA expression profiling and built on ... on-chip synthesis platform. These microarrays are ... microRNA Expression Profiling Service. ... Microarray contains all known rice microRNAs ...
... manufactured by Stoelting, selects single cells, or ... no time at all, a single cell ... keypad...the cell is collected into the pipette, ... of a microtiter plate. Quixells unique aspiration ...
Biology Products: