Navigation Links
Synthetic sperm protein raises the chance for successful in vitro fertilization
Date:9/30/2014

Having trouble getting pregnanteven with IVF? Here's some hope: A new research report published in October 2014 issue of The FASEB Journal, explains how scientists developed a synthetic version of a sperm-originated protein known as PAWP, which induced embryo development in human and mouse eggs similar to the natural triggering of embryo development by the sperm cell during fertilization.

"We believe that the results of this study represent a major paradigm shift in our understanding of human fertilization by providing a precise answer to a fundamental unresolved scientific question in developmental biology," said Mahmoud Aarabi, M.D., Ph.D., a researcher involved in the work from the Department of Human Genetics at Montreal Children's Hospital Research Institute in Montreal, Canada. "Based on our findings, we envision that physicians will be able to improve their diagnosis and treatment of infertility, a problem that affects 10-15 percent of couples worldwide, and scientists will be able to finally resolve the signalling pathway leading to initiation of embryonic development in mammals."

To make their advance, Aarabi and colleagues injected transcripts coding for PAWP protein into human eggs, and the immediate fertilization events, including release of calcium inside the eggs, were investigated carefully. (The human eggs used in this study were donated by infertile women and consisted of immature eggs that were further matured in the laboratory and thus were not suitable for IVF.) The injected eggs were fixed before cell division. A similar protocol was used in mice where the PAWP protein was injected into the eggs. The scientists found that when PAWP inhibitors were injected with the sperm cell into the eggs, a procedure known as ICSI in human infertility therapy, they blocked the sperm-induced fertilization. This is the first time that any sperm protein is shown to be susceptible to such an important inhibition effect.

"Reducing the number of IVF cycles for couple would save them money and disappointment," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Equally important, this research helps us better understand the events that occur when an egg is first fertilized as well as what we can do to influence those events."


'/>"/>
Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
@fasebopa
Source:Eurekalert

Related biology news :

1. New synthetic biology technique boosts microbial production of diesel fuel
2. UC Santa Barbara researchers develop synthetic platelets
3. Synthetic diamond steps closer to next generation of high performance electrochemical applications
4. Synthetic Biology Scorecard finds federal agencies responding to bioethics report
5. Collagen-seeking synthetic protein could lead doctors to tumor locations
6. Synthetic biofilter wins through to the top Sweet 16 in Boston
7. Nottingham part of £20m investment for UK synthetic biology
8. Microchoreography: Researchers use synthetic molecule to guide cellular dance
9. Synthetic fuel could eliminate US need for crude oil
10. New report finds increase in media coverage of synthetic biology
11. Synthetic and biological nanoparticles combined to produce new metamaterials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/13/2018)... ... December 13, 2018 , ... Study Protocol Summary of QC Procedure ... e-CRF®): IGA first assessment performed at the site., 3 - Three photos captured with ... Photo anonymization in BOX., 5 - Photos moved to eAdjudication® and submitted to Reviewers., ...
(Date:12/13/2018)... ... December 12, 2018 , ... Royal Biologics, an ortho-biologics ... announced the launch of Maxx-Cell, the world's most advanced bone marrow aspiration device. ... a patients autologous bone marrow cells. Maxx™-Cell however does not require centrifugation to ...
(Date:12/13/2018)... Fla. (PRWEB) , ... December 12, 2018 , ... New ... preventing the growing problem of drowsy and distracted driving, one of the main causes ... under the guidance of Dr. Kanwal Gagneja , assistant professor of computer science, ...
Breaking Biology News(10 mins):
(Date:11/20/2018)... ... 19, 2018 , ... Patients with missing teeth in Sandy Springs, GA, Alpharetta, ... Dan Myers at THE DENTIST Centers without a referral. Dr. Myers is a skilled ... 20 years. He now offers skilled dental care in two practice locations THE DENTIST ...
(Date:11/13/2018)... ... 2018 , ... Renowned Honolulu veterinarian, Dr. Patrick Leadbeater, has begun offering ... Leadbeater, of Kahala Pet Hospital on Oahu, is a skilled surgeon who ... the island of Kauai on an almost weekly basis to perform surgery at ...
(Date:11/13/2018)... ... 13, 2018 , ... , Park Systems, world leader in Atomic Force Microscopes ... demand for AFM technology in China, Park Systems has decided to provide direct support ... Beijing equipped with Park AFM. , The Grand Opening of the Park Beijing Office ...
(Date:11/9/2018)... ... November 08, 2018 , ... IC ... a machine-learning powered approach to increasing recovery rates by creating a comprehensive contact ... Collections (AIC) product developed by NLP Logix, a Jacksonville, Florida-based AI solutions company, ...
Breaking Biology Technology: